Results 111 to 120 of about 156,551 (297)

Successive translocation into and out of the mitochondrial matrix [PDF]

, 1987
We investigated the import and sorting pathways of cytochrome b2 and cytochrome c1, which are functionally located in the intermembrane space of mitochondria.
Ostermann, Joachim, Hartl, Franz-Ulrich, Neupert, Walter, Guiard, Bernard   +3 more
core   +1 more source

Modulation of Mitochondrial Dynamics in Primary Hippocampal Cultures of 5xFAD Mice by Mdivi-1, MFP, and Exogenous Zinc

Frontiers in Bioscience-Landmark
Background: Mitochondrial dynamics—the balance between fission, fusion, and mitophagy—are essential for maintaining cellular homeostasis and are increasingly implicated in the pathogenesis of Alzheimer’s disease (AD).
Alina Chaplygina, Daria Zhdanova
doaj   +1 more source

Mechanically Spatio‐Chimeric Fibrin Assembly Enables Vascular‐Integrated Muscle Reconstruction for Volumetric Muscle Loss Repair

Advanced Materials, EarlyView.
SPARC (spatio‐chimeric, plasma‐based, anisotropic, and shear‐responsive construct) that integrates myogenic and vascular microenvironments within a single construct. The dual‐modulus matrix directs aligned myotube formation and endothelial network development, enabling a vascularized muscle implant that seamlessly anastomoses with host tissue and ...
Su Hyun Jung, Minjun Kim, Da‐Yoon Kim, Min Kyu Kim, Sieun Lee, Yoonhee Jin, Joo H. Kang   +6 more
wiley   +1 more source

TIM23-mediated insertion of transmembrane alpha-helices into the mitochondrial inner membrane

, 2011
While overall hydrophobicity is generally recognized as the main characteristic of transmembrane (TM) alpha-helices, the only membrane system for which there are detailed quantitative data on how different amino acids contribute to the overall efficiency
Koji Yamano, Björkholm, Patrik, Kim, Hyun, von Heijne, Gunnar, Toshiya Endo, Botelho, Salomé Calado, Reichert, Andreas S., Patrik Björkholm, Kim, Hyun,, Reichert, Andreas, Endo, Toshiya, Hyun Kim, Österberg, Marie,, Salomé Calado Botelho, Marie Österberg, von Heijne, Gunnar,, Österberg, Marie, Andreas S Reichert, Björkholm, Patrik,, Yamano, Koji, Heijne, Gunnar von, Botelho, Salomé Calado,, Gunnar von Heijne   +22 more
core   +1 more source

Restriction of trophic factors and nutrients induces PARKIN expression [PDF]

, 2011
Parkinson's disease (PD) is the most frequent neurodegenerative movement disorder and manifests at old age. While many details of its pathogenesis remain to be elucidated, in particular the protein and mitochondrial quality control during stress ...
Klinkenberg, Michael, Auburger, Georg, S. Gispert, Braun, Isabelle, M. Klinkenberg, Dominguez Bautista, Jorge Antolio, M. Jendrach, Gispert, Suzana, G. Auburger, J. A. Dominguez-Bautista, I. Braun, Jendrach, Marina   +11 more
core   +1 more source

Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction

Frontiers in Aging Neuroscience, 2015
Mitochondrial dynamics is a term that encompasses the movement of mitochondria along the cytoskeleton, regulation of their architecture, and connectivity mediated by tethering and fusion/fission.
Antonio eZorzano, Marc eClaret
doaj   +1 more source

Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract

Advanced Robotics Research, EarlyView.
We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis, Luis Carlos Sanjuan Acosta, Shubh P. Mehta, Baiyan Qi, Yang Yang, Luis Solorio, Craig J. Goergen, David J. Cappelleri   +7 more
wiley   +1 more source

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

Mitochondrial Fusion and Division

The FASEB Journal, 2012
Mitochondria play important roles in cellular functions including energy production, metabolism and cell death. Mitochondria are highly dynamic organelles that continuously fuse and divide in a regulated manner. A balance of fusion and division controls mitochondrial morphology and functions.
openaire   +1 more source

The control of mitochondrial morphology and dynamics in Arabidopis thaliana

, 2012
Mitochondria are ubiquitous eukaryotic organelles which carry out a range of essential functions, most notably the production of ATP through the process of oxidative phosphorylation.
Scott, Iain
core