Results 51 to 60 of about 704,132 (300)
Modulation of myometrium mitochondrial membrane potential by calmodulin antagonists [PDF]
The Ukrainian Biochemical Journal, 2014 Influence of calmodulin antagonists on mitochondrial membrane potential was investigated using a flow cytometry method, confocal microscopy and fluorescent potential-sensitive probes TMRM and MTG.
S. G. Shlykov +4 more
doaj +1 more source
Cytoprotective effects of melatonin against amitriptyline-induced toxicity in isolated rat hepatocytes [PDF]
, 2015 Purpose: Amitriptyline, one of the commonly used tricyclic antidepressants, caused rare but severe hepatotoxicity in patients who received it continuously. Previous findings showed that the intermediate metabolites of amitriptyline produced by CYP450 are
Dastmalchi, S. +3 more
core +1 more source
Imaging mitochondrial membrane potentials
Biophysical Journal, 1993 process remain to be elucidated. The elusiveness of this goal can be attributed, at least in part, to the absence of structural information about the mitochondrion itself at several levels of complexity. It is obvious, for example, that obtaining atomic structures of the respiratory chain protein complexes by x-ray or electron crystallography would ...
openaire +2 more sources
Neurobiology of Disease, 2011 Mutations in PTEN-induced putative kinase 1 (PINK1) cause a recessive form of Parkinson's disease (PD). PINK1 is associated with mitochondrial quality control and its partial knock-down induces mitochondrial dysfunction including decreased membrane ...
Taku Amo +8 more
doaj +1 more source
Calcineurin, Mitochondrial Membrane Potential, and Cardiomyocyte Apoptosis [PDF]
Circulation Research, 2001 Mitochondria comprise ≈30% of the total intracellular volume within a mammalian cardiomyocyte.1 2 Not surprisingly, subtle alterations in mitochondrial function or membrane potential can have a dramatic influence on cardiomyocyte energy production and, ultimately, the health of an individual cell.
openaire +2 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Bio-Protocol, 2019 In recent years, fluorescent dyes have been frequently used for monitoring mitochondrial membrane potential to evaluate mitochondrial viability and function.
Farzane Sivandzade +2 more
doaj +1 more source
The role of DJ-1 in enhancing mitochondrial quality control [PDF]
, 2013 Thesis (M.A.)--Boston UniversityDJ-1 is a cytosolic sensor for oxidative damage which acts on the Mitochondria. It works to curb the negative effects of high membrane potential in mitochondria, but the mechanism of action is still uncertain.
Lingiah, Krishna Anand
core +1 more source
Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons [PDF]
, 2017 Mutations in the gene encoding valosin-containing protein (VCP) lead to multisystem proteinopathies including frontotemporal dementia. We have previously shown that patient-derived VCP mutant fibroblasts exhibit lower mitochondrial membrane potential ...
Abramov +43 more
core +2 more sources
Mitochondrial membrane potential and aging
Aging Cell, 2003 SummaryThe mitochondrial membrane potential (or protonmotive force) is the central bioenergetic parameter that controls respiratory rate, ATP synthesis and the generation of reactive oxygen species, and is itself controlled by electron transport and proton leaks.
openaire +2 more sources