Results 161 to 170 of about 426,171 (247)

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Nutrient Sensing and Growth Control in Plasmodium: Beyond mTOR Signaling

Molecular Microbiology, EarlyView.
Plasmodium parasites lack the canonical mTOR kinase and associated signaling complexes, yet retain key mTOR‐like functions. Parasite‐specific nutrient sensors, kinases, and translational regulators coordinate growth, stress adaptation, metabolic plasticity, and developmental decisions through a distributed regulatory network.
Felix Müller, Gabriele Pradel
wiley   +1 more source

Impaired mitochondrial proteostasis underlies cardiomyocyte bioenergetic dysfunction in a murine three-hit model of heart failure with preserved ejection fraction. [PDF]

Am J Physiol Heart Circ Physiol
Li X, Fu Y, do Carmo JM, da Silva AA, Mouton AJ, Omoto ACM, Wang L, Hall JE, Wang Z.   +8 more
europepmc   +1 more source

Mitochondrial entry gate as regulatory hub

Mitochondria import 1000–1300 different precursor proteins from the cytosol. The main mitochondrial entry gate is formed by the translocase of the outer membrane (TOM complex).
Pfanner, Nikolaus, Brave, Fabian den, Becker, Thomas   +2 more
core   +1 more source

Embryonal degreening and seed longevity require plastid LEA proteins

New Phytologist, EarlyView.
Working model of how plastidial LEA proteins aid the remodelling of photosynthetic structures during degreening of Arabidopsis seed embryos. LEA42 and LEA48 support thylakoid proteostasis and membrane remodelling in embryonal cells during late seed maturation by maintaining a local physicochemical environment compatible with protein turnover and ...
Dennis Brandt, Ana Carolina Vilchez, Jürgen Eirich, Paulina Heinkow, Lea Hembach, Ke Zheng, Pedro Barreto, Jan‐Ole Niemeier, Lando Lebok, Ivo Feussner, Felix Buchert, Alexey Amunts, Kristina Kühn, David Macherel, Till Ischebeck, Michael Melzer, Iris Finkemeier, Markus Schwarzländer   +17 more
wiley   +1 more source

Mitochondrial Proteostasis Links Diabetes and Sarcopenia: Cross-Scale Convergence from Experimental Models to Human Multi-Omics. [PDF]

Diabetes Metab J
Wei S, Shin S, Ryu D, Oh CM.
europepmc   +1 more source

Evolutionary Conserved and Divergent Responses to Copper Zinc Superoxide Dismutase Inhibition in Plants

Plant, Cell &Environment, EarlyView.
ABSTRACT After an initial evolution in a reducing environment, life got successively challenged by reactive oxygen species (ROS), especially during the great oxidation event (GOE) that followed the development of photosynthesis. Therefore, ROS are deeply intertwined into the physiological, morphological and transcriptional responses of most present‐day
Stephanie Frohn, Fabian B. Haas, Benjamin G. Chavez, Bernd H. Dreyer, Erik V. Reiss, Anne Ziplys, Heiko Weichert, Saskia Hiltemann, José M. Ugalde, Andreas J. Meyer, John C. D'Auria, Stefan A. Rensing, Jos H. M. Schippers   +12 more
wiley   +1 more source

Molecular Chaperone Networks in Plants: Maintaining Proteostasis and Enhancing Stress Resilience for Crop Improvement

Plant, Cell &Environment, EarlyView.
ABSTRACT Molecular chaperones play a central role in the plant proteostasis machinery by aiding the folding of nascent proteins, preventing aggregation, and repairing or degrading damaged proteins. These functions are especially essential during abiotic and biotic stress, which can destabilise cellular proteins and disrupt metabolic homoeostasis.
Mingfang Yang, Anqin Gao, Tsz‐Yan Chan, Hafiz Mamoon Rehman, Sehar Nawaz, Sehrish Bashir, Noman Mahmood, Muhammad Wajid Ullah, Chunlin Long, Hon‐Ming Lam, Muhammad Arif   +10 more
wiley   +1 more source

PROTEOSTASIS AS A SIGNALING DEVICE AND THERAPEUTIC TARGET

, 2011
The term ‘conformational disorders’ was created recently for the numerous pathological situations due to the accumulation of aberrant proteins (or normal ones in excess).
CENCI S, SITIA , ROBERTO
core  

Molecular Links Between Heat Stress and DNA Damage Response in Plants

Plant, Cell &Environment, EarlyView.
ABSTRACT Climate change poses a major threat to agricultural productivity and, consequently, to global food security. Among the consequences of climate change, heat stress (HS) has emerged as a critical factor limiting crop performance. This has stimulated extensive research over the past decade to elucidate the molecular and physiological mechanisms ...
Adrian Calves‐Ubach, Miriam Szurman‐Zubrzycka   +1 more
wiley   +1 more source