Results 11 to 20 of about 2,844 (161)

The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier

Biomolecules, 2020
Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation.
Joséphine Zangari, Francesco Petrelli, Benoît Maillot, Jean-Claude Martinou   +3 more
doaj   +3 more sources

The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity

Molecular Metabolism, 2017
Objective: Excessive hepatic gluconeogenesis is a defining feature of type 2 diabetes (T2D). Most gluconeogenic flux is routed through mitochondria. The mitochondrial pyruvate carrier (MPC) transports pyruvate from the cytosol into the mitochondrial ...
Adam J. Rauckhorst, Lawrence R. Gray, Ryan D. Sheldon, Xiaorong Fu, Alvin D. Pewa, Charlotte R. Feddersen, Adam J. Dupuy, Katherine N. Gibson-Corley, James E. Cox, Shawn C. Burgess, Eric B. Taylor   +10 more
doaj   +3 more sources

Mitochondrial Pyruvate Carrier Function in Health and Disease across the Lifespan

Biomolecules, 2020
As a nodal mediator of pyruvate metabolism, the mitochondrial pyruvate carrier (MPC) plays a pivotal role in many physiological and pathological processes across the human lifespan, from embryonic development to aging-associated neurodegeneration ...
Jane L. Buchanan, Eric B. Taylor
doaj   +3 more sources

A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPC. [PDF]

Elife, 2020
Mitochondria generate ATP and building blocks for cell growth and regeneration, using pyruvate as the main substrate. Here we introduce PyronicSF, a user-friendly GFP-based sensor of improved dynamic range that enables real-time subcellular quantitation ...
Arce-Molina R, Cortés-Molina F, Sandoval PY, Galaz A, Alegría K, Schirmeier S, Barros LF, San Martín A.   +7 more
europepmc   +2 more sources

The yeast mitochondrial pyruvate carrier is a hetero-dimer in its functional state. [PDF]

EMBO Journal, 2019
The mitochondrial pyruvate carrier (MPC) is critical for cellular homeostasis, as it is required in central metabolism for transporting pyruvate from the cytosol into the mitochondrial matrix.
Harbour, Michael E, Kunji, Edmund Rs, Martinou, Jean-Claude, Mavridou, Vasiliki, Tavoulari, Sotiria, Thangaratnarajah, Chancievan   +5 more
core   +3 more sources

miR-449a/miR-340 reprogram cell identity and metabolism in fusion-negative rhabdomyosarcoma [PDF]

Cell Reports
: Rhabdomyosarcoma (RMS), the most common pediatric soft tissue sarcoma, arises in skeletal muscle and remains in an undifferentiated state due to transcriptional and post-transcriptional regulators.
Carmeliet, Peter, Degreef, Ewoud, Eelen, Guy, Fanzani, Alessandro, Fendt, Sarah-Maria, Garrido, Gabriel Miró, Giarratana, Nefele, Koh, Kian Peng, Marini, Vittoria, Planque, Mélanie, Pozzo, Enrico, Rinaldi, Gianmarco, Sampaolesi, Maurilio, Sassi, Gabriele, Uyttebroeck, Anne, van der Veer, Bernard K., Wang, Chao-chi, Yedigaryan, Laura, Yustein, Jason T.   +18 more
core   +4 more sources

Reprogramming hormone-sensitive prostate cancer to a lethal neuroendocrine cancer lineage by mitochondrial pyruvate carrier (MPC). [PDF]

Mol Metab, 2022
Cell lineage reprogramming is the main approach for cancer cells to acquire drug resistance and escape targeted therapy. The use of potent targeted therapies in cancers has led to the development of highly aggressive carcinoma, including neuroendocrine ...
Xu H, Liu Z, Gao D, Li P, Shen Y, Sun Y, Xu L, Song N, Wang Y, Zhan M, Gao X, Wang Z.   +11 more
europepmc   +2 more sources

Structure of human mitochondrial pyruvate carrier MPC1 and MPC2 complex. [PDF]

Nat Commun
The Mitochondrial Pyruvate Carrier (MPC) bridges cytosolic and mitochondrial metabolism by transporting pyruvate into mitochondria for ATP production and biosynthesis of various essential molecules.
Sun Y, Wang Y, Xing Z, Li D, Wang R, Chen B, Zhou N, Ayala A, Tu BP, Qi X.   +9 more
europepmc   +2 more sources

[3-¹¹C]Pyruvate PET detects alterations in cardiac pyruvate metabolism induced by doxorubicin chemotherapy. [PDF]

Npj Imaging
Changes in cardiac metabolism typically precede cardiac dysfunction and therefore represent an important target for diagnosis and treatment designed to prevent progression to heart failure, a leading cause of death.
Lee CH, Ruan T, Debnath S, Wacker AS, Figlioli G, Babich JW, Nehmeh SA, Keshari KR, Kelly JM.   +8 more
europepmc   +2 more sources

Reduced mitochondrial pyruvate carrier expression in hearts with heart failure and reduced ejection fraction patients: ischemic vs. non-ischemic origin [PDF]

Frontiers in Cardiovascular Medicine
[Abstract] Introduction and objectives: Mitochondrial pyruvate carrier (MPC) mediates the entry of pyruvate into mitochondria, determining whether pyruvate is incorporated into the Krebs cycle or metabolized in the cytosol. In heart failure (HF), a large
Barge-Caballero, Eduardo, Barge-Caballero, Gonzalo, Blanco-Canosa, Paula, Couto-Mallón, David, Crespo-Leiro, María Generosa, Doménech, Nieves, Enríquez-Vázquez, Daniel, Fernández-Caggiano, Mariana, Grille-Cancela, Zulaika, López-Vázquez, Paula, Paniagua-Martín, María J., Vázquez-Rodríguez, José M.   +11 more
core   +3 more sources