Results 21 to 30 of about 2,844 (161)
Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy
BMC Nephrology, 2020 Background Mitochondrial dysfunction contributes to the pathogenesis of diabetic nephropathy (DN). Mitochondrial pyruvate carrier 1 (MPC1) and mitochondrial pyruvate carrier 2 (MPC2) play a bottleneck role in the transport of pyruvate into mitochondrial ...
Huanhuan Zhu +10 more
doaj +1 more source
The Metabolic Role of Mitochondria in the Perinatal Cardiac Development and Cardiovascular Diseases. [PDF]
Exploration (Beijing)This review explores the critical role of mitochondria in heart development and cardiovascular disease. It highlights how mitochondrial maturation during embryonic‐to‐postnatal transition, regulated by oxygen and metabolic changes, shapes cardiac structure and function.
Li M, Zhang R, Li X, Huang H.
europepmc +2 more sources
iScience, 2023 Summary: The liver coordinates the systemic response to nutrient deprivation and availability by producing glucose from gluconeogenesis during fasting and synthesizing lipids via de novo lipogenesis (DNL) when carbohydrates are abundant.
Nicole K.H. Yiew +12 more
doaj +1 more source
Cell Reports, 2020 Summary: Mitochondria are key organelles for brain health. Mitochondrial alterations have been reported in several neurodegenerative disorders, including Alzheimer’s disease (AD), and the comprehension of the underlying mechanisms appears crucial to ...
Alice Rossi +6 more
doaj +1 more source
Cell-Type-Dependent Metabolic Compensation Preserves Photoreceptor Survival Through Pyruvate Kinase Isoform Balance. [PDF]
FASEB JWe investigated the roles of PKM2, PKM1, and LDHA in retinal metabolism and structural integrity. In the normal retina, these enzymes are maintained at defined levels that support photoreceptor function. Rod‐specific deletion of LDHA, alone or with PKM2, caused age‐dependent degeneration, as PKM1 induction did not reach levels comparable to PKM2.
Rajala A +3 more
europepmc +2 more sources
BMC Biology, 2020 Background The mitochondrial pyruvate carrier (MPC) plays a central role in energy metabolism by transporting pyruvate across the inner mitochondrial membrane.
Heike Rampelt +9 more
doaj +1 more source
Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet. [PDF]
PLoS Genetics, 2016 Mitochondrial import of pyruvate by the mitochondrial pyruvate carrier (MPC) is a central step which links cytosolic and mitochondrial intermediary metabolism.
Benoît Vanderperre +8 more
doaj +1 more source
Biomolecules, 2023 Pyruvate sits at an important metabolic crossroads of intermediary metabolism. As a product of glycolysis in the cytosol, it must be transported into the mitochondrial matrix for the energy stored in this nutrient to be fully harnessed to generate ATP or
Kyle S. McCommis, Brian N. Finck
doaj +1 more source
An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion
Molecular Metabolism, 2016 Objective: Transport of pyruvate into the mitochondrial matrix by the Mitochondrial Pyruvate Carrier (MPC) is an important and rate-limiting step in its metabolism.
Kyle S. McCommis +7 more
doaj +1 more source
Cancer Biology & Medicine, 2022 Objective: This study aimed to evaluate the effects of mitochondrial pyruvate carrier (MPC) blockade on the sensitivity of detection and radiotherapy of prostate cancer (PCa).
Huan Xu +16 more
doaj +1 more source