Results 31 to 40 of about 2,844 (161)

Experimental Investigations on the Structure of Yeast Mitochondrial Pyruvate Carriers

Membranes, 2022
Mitochondrial pyruvate carrier (MPC) transports pyruvate from the cytoplasm into the mitochondrial matrix to participate in the tricarboxylic acid (TCA) cycle, which further generates the energy for the physiological activities of cells.
Ling Li, Maorong Wen, Changqing Run, Bin Wu, Bo OuYang   +4 more
doaj   +1 more source

Treating hepatic steatosis and fibrosis by modulating mitochondrial pyruvate metabolism [PDF]

, 2019
A hepatic comorbidity of metabolic syndrome, known as nonalcoholic fatty liver disease (NAFLD), is increasing in prevalence in conjunction with the pandemics of obesity and diabetes.
Finck, Brian N, McCommis, Kyle S
core   +2 more sources

Bonded Cumomer Analysis of Human Melanoma Metabolism Monitored by 13C NMR Spectroscopy of Perfused Tumor Cells. [PDF]

, 2015
A network model for the determination of tumor metabolic fluxes from (13)C NMR kinetic isotopomer data has been developed and validated with perfused human DB-1 melanoma cells carrying the BRAF V600E mutation, which promotes oxidative metabolism.
Blair, Ian A, Glickson, Jerry D, Guo, Lili, Henry, Pierre-Gilles, Lee, Seung-Cheol, Leeper, Dennis B, Mancuso, Anthony, Nelson, David S, Roman, Jeffrey C, Shestov, Alexander A   +9 more
core   +2 more sources

A genetic toolkit for the analysis of metabolic changes in Drosophila provides new insights into metabolic responses to stress and malignant transformation [PDF]

, 2019
Regulation of the energetic metabolism occurs fundamentally at the cellular level, so analytical strategies must aim to attain single cell resolution to fully embrace its inherent complexity.
Behrensen, C., Durrieu, Lucía, Gándara, Lautaro, Wappner, Pablo   +3 more
core   +1 more source

Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development

Cell Reports, 2020
Summary: Metabolic pathways regulate T cell development and function, but many remain understudied. Recently, the mitochondrial pyruvate carrier (MPC) was identified as the transporter that mediates pyruvate entry into mitochondria, promoting pyruvate ...
Andrew G. Ramstead, Jared A. Wallace, Soh-Hyun Lee, Kaylyn M. Bauer, William W. Tang, H. Atakan Ekiz, Thomas E. Lane, Ahmad A. Cluntun, Matthew L. Bettini, June L. Round, Jared Rutter, Ryan M. O’Connell   +11 more
doaj   +1 more source

(13)C MRS and LC-MS Flux Analysis of Tumor Intermediary Metabolism. [PDF]

, 2016
We present the first validated metabolic network model for analysis of flux through key pathways of tumor intermediary metabolism, including glycolysis, the oxidative and non-oxidative arms of the pentose pyrophosphate shunt, the TCA cycle as well as its
Blair, Ian A., Glickson, Jerry D., Guo, Lili, Lee, Seung-Cheol, Leeper, Dennis B., Nath, Kavindra, Nelson, David S., Roman, Jeffrey C., Shestov, Alexander A., Wasik, Mariusz A.   +9 more
core   +2 more sources

Structure of mitochondrial pyruvate carrier and its inhibition mechanism. [PDF]

Nature
He Z, Zhang J, Xu Y, Fine EJ, Suomivuori CM, Dror RO, Feng L.   +6 more
europepmc   +2 more sources

Berberine Reduces Pyruvate-driven Hepatic Glucose Production by Limiting Mitochondrial Import of Pyruvate through Mitochondrial Pyruvate Carrier 1Research in Context

EBioMedicine, 2018
Background: Mitochondrial pyruvate import via mitochondrial pyruvate carrier (MPC) is a central step in hepatic gluconeogenesis. Berberine inhibits hepatic gluconeogenesis, but the mechanism is incompletely understood.
Aiyun Li, Qun Liu, Qiang Li, Baolin Liu, Yang Yang, Ning Zhang   +5 more
doaj   +1 more source

Branched-chain keto acids inhibit mitochondrial pyruvate carrier and suppress gluconeogenesis in hepatocytes

Cell Reports, 2023
Summary: Branched-chain amino acid (BCAA) metabolism is linked to glucose homeostasis, but the underlying signaling mechanisms are unclear. We find that gluconeogenesis is reduced in mice deficient of Ppm1k, a positive regulator of BCAA catabolism, which
Kiyoto Nishi, Akira Yoshii, Lauren Abell, Bo Zhou, Ricardo Frausto, Julia Ritterhoff, Timothy S. McMillen, Ian Sweet, Yibin Wang, Chen Gao, Rong Tian   +10 more
doaj   +1 more source

L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade. [PDF]

, 2016
Converging experimental data indicate a neuroprotective action of L-Lactate. Using Digital Holographic Microscopy, we observe that transient application of glutamate (100 μM; 2 min) elicits a NMDA-dependent death in 65% of mouse cortical neurons in ...
Allaman, I., Fiumelli, H., Jourdain, P., Magistretti, P.J., Marquet, P., Rothenfusser, K.   +5 more
core   +2 more sources