Results 111 to 120 of about 16,238 (247)

Mitochondrial alterations as potential early events in neuromuscular junction remodelling with muscle disuse

Experimental Physiology, EarlyView.
Abstract Physical inactivity impairs neuromuscular health, promoting skeletal muscle atrophy, mitochondrial changes, and neuromuscular junction (NMJ) instability. However, the interplay between mitochondria and NMJ alterations in the context of muscle disuse remains underexplored.
Evgeniia Motanova, Evgenii Lysenko, Fabio Sarto, Mladen Gasparini, Boštjan Šimunic, Rado Pišot, Marco V. Narici   +6 more
wiley   +1 more source

Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications

Redox Biology, 2017
Mitochondria play a key role in maintaining cellular metabolic homeostasis. These organelles have a high plasticity and are involved in dynamic processes such as mitochondrial fusion and fission, mitophagy and mitochondrial biogenesis. Type 2 diabetes is
Susana Rovira-Llopis, Celia Bañuls, Noelia Diaz-Morales, Antonio Hernandez-Mijares, Milagros Rocha, Victor M. Victor   +5 more
doaj   +1 more source

Highlighting the endoplasmic reticulum-mitochondria connection: Focus on Mitofusin 2

Pharmacological Research, 2018
The endoplasmic reticulum (ER) and the mitochondrial network are two highly interconnected cellular structures. By proteinaceous tethers, specialized membrane domains of the ER are tightly associated with the outer membrane of mitochondria, allowing the assembly of signaling platforms where different cell functions take place or are modulated, such as ...
Filadi, Riccardo, Greotti, Elisa, Pizzo, Paola   +2 more
openaire   +3 more sources

Skeletal muscle mitochondrial marker responses to a single bout and 6 weeks of high load versus high volume resistance training in previously trained men

Experimental Physiology, EarlyView.
Abstract The effects of high‐load (HL) versus high‐volume (HV) resistance training (RT) on various molecular outcomes are similar. However, mitochondrial responses remain understudied. Therefore, the purpose of this study was to interrogate mitochondrial mRNA and protein responses to acute and chronic HL versus HV RT.
Breanna Mueller, Carlton D. Fox, Hailey A. Parry, Paulo H. C. Mesquita, Christopher G. Vann, Bradley A. Ruple, Casey L. Sexton, Joshua S. Godwin, Mason M. McIntosh, Darren T. Beck, Kaelin C. Young, Stuart M. Phillips, Andreas N. Kavazis, Michael D. Roberts   +13 more
wiley   +1 more source

Charcot-Marie-tooth disease type 2A: An update on pathogenesis and therapeutic perspectives

Neurobiology of Disease
Mutations in the gene encoding MFN2 have been identified as associated with Charcot–Marie–Tooth disease type 2A (CMT2A), a neurological disorder characterized by a broad clinical phenotype involving the entire nervous system.
Claudia Alberti, Federica Rizzo, Alessia Anastasia, Giacomo Comi, Stefania Corti, Elena Abati   +5 more
doaj   +1 more source

Mitofusin 2 Is Essential for IP3-Mediated SR/Mitochondria Metabolic Feedback in Ventricular Myocytes

Frontiers in Physiology, 2019
Aim: Endothelin-1 (ET-1) and angiotensin II (Ang II) are multifunctional peptide hormones that regulate the function of the cardiovascular and renal systems.
Lea K. Seidlmayer, Lea K. Seidlmayer, Christine Mages, Christine Mages, Annette Berbner, Petra Eder-Negrin, Paula Anahi Arias-Loza, Mathias Kaspar, Moshi Song, Gerald W. Dorn, Michael Kohlhaas, Stefan Frantz, Stefan Frantz, Christoph Maack, Brenda Gerull, Elena N. Dedkova, Elena N. Dedkova   +16 more
doaj   +1 more source

Reduced alfa-MSH underlies hypothalamic ER-stress-induced hepatic gluconeogenesis [PDF]

, 2016
Alterations in ER homeostasis have been implicated in the pathophysiology of obesity and type-2 diabetes (T2D). Acute ER stress induction in the hypothalamus produces glucose metabolism perturbations.
Altirriba Gutiérrez, Jordi, Bortolozzi Biasoni, Analía, Claret i Carles, Marc, Drougard, Anne, Esteban, Yaiza, Ferrés Coy, Albert, Garcia, Ainhoa, García-Roves, Pablo M. (Pablo Miguel), Gomis, Ramon, 1946-, Gómez Valadés, Alicia G., Jones, John G., Manadas, Bruno, Ramírez, Sara, Schneeberger, Marc, Sebastián Muñoz, David, Zorzano Olarte, Antonio   +15 more
core   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Small Molecule Activators of Mitochondrial Fusion Prevent Congenital Heart Defects Induced by Maternal Diabetes

JACC: Basic to Translational Science
Summary: Most congenital heart defect (CHD) cases are attributed to nongenetic factors; however, the mechanisms underlying nongenetic factor–induced CHDs are elusive.
Guanglei Wang, PhD, Wenhui Lu, PhD, Wei-Bin Shen, PhD, Mariusz Karbowski, PhD, Sunjay Kaushal, MD, PhD, Peixin Yang, PhD   +5 more
doaj   +1 more source

Mitochondrial genome linearization is a causative factor for cardiomyopathy in mice and Drosophila [PDF]

, 2014
Aims: Mitofusin (Mfn)2 redundantly promotes mitochondrial outer membrane tethering and organelle fusion with Mfn1, and uniquely functions as the mitochondrial receptor for Parkin during PTEN-induced putative kinase 1 (PINK1)-Parkin-mediated mitophagy ...
Bhandari, Poonam, Chen, Yun, Dorn, Gerald W, Matkovich, Scot J, Sparks, Megan   +4 more
core   +2 more sources