Results 11 to 20 of about 16,238 (247)

Mitofusin-2 Regulates Platelet Mitochondria and Function. [PDF]

Circ Res, 2023
BACKGROUND: Single-nucleotide polymorphisms linked with the rs1474868 T allele ( MFN2 [mitofusin-2] T/T) in the human mitochondrial fusion protein MFN2 gene are associated with reduced platelet MFN2 RNA expression and platelet ...
Jacob S, Kosaka Y, Bhatlekar S, Denorme F, Benzon H, Moody A, Moody V, Tugolukova EA, Hull G, Kishimoto N, Manne BK, Guo L, Souvenir R, Seliger BJ, Eustes AS, Hoerger K, Tolley ND, Fatahian AN, Boudina S, Christiani DC, Wei Y, Ju C, Campbell RA, Rondina MT, Abel ED, Bray PF, Weyrich AS, Rowley JW.   +27 more
europepmc   +5 more sources

Mitofusin-2: A New Mediator of Pathological Cell Proliferation [PDF]

Frontiers in Cell and Developmental Biology, 2021
Cell proliferation is an important cellular process for physiological tissue homeostasis and remodeling. The mechanisms of cell proliferation in response to pathological stresses are not fully understood.
Yanguo Xin, Junli Li, Wenchao Wu, Xiaojing Liu, Xiaojing Liu   +4 more
doaj   +5 more sources

Mitofusin 2 Dysfunction and Disease in Mice and Men [PDF]

Frontiers in Physiology, 2020
A causal relationship between Mitofusin (MFN) 2 gene mutations and the hereditary axonal neuropathy Charcot-Marie-Tooth disease type 2A (CMT2A) was described over 15 years ago. During the intervening period much has been learned about MFN2 functioning in
Gerald W. Dorn
doaj   +4 more sources

Role of mitofusin 2 in the renal stress response. [PDF]

PLoS ONE, 2012
The role of mitofusin 2 (MFN2), a key regulator of mitochondrial morphology and function in the renal stress response is unknown. To assess its role, the MFN2 floxed gene was conditionally deleted in the kidney of mice (MFN2 cKO) by Pax2 promoter driven ...
Jonathan M Gall, Zhiyong Wang, Marc Liesa, Anthony Molina, Andrea Havasi, John H Schwartz, Orian Shirihai, Steven C Borkan, Ramon G B Bonegio   +8 more
doaj   +4 more sources

Mitofusin 2 is required for preventing deoxynivalenol-induced porcine intestinal epithelial cell damage [PDF]

Journal of Animal Science and Biotechnology
Backgrounds Deoxynivalenol (DON) is an abundant environmental pollutant in feed, posing serious health hazards to animals. However, whether DON triggers an imbalance in mitochondrial fission/fusion and the underlying mechanisms involved remain poorly ...
Kan Xiao, Minfang Zhang, Qingqing Lv, Feifei Huang, Qilong Xu, Junjie Guo, Jiangchao Zhao, Huiling Zhu, Shaokui Chen, Yulan Liu   +9 more
doaj   +2 more sources

Pooled image-base screening of mitochondria with microraft isolation distinguishes pathogenic mitofusin 2 mutations. [PDF]

Commun Biol, 2022
Yenkin AL, Bramley JC, Kremitzki CL, Waligorski JE, Liebeskind MJ, Xu XE, Chandrasekaran VD, Vakaki MA, Bachman GW, Mitra RD, Milbrandt JD, Buchser WJ.   +11 more
europepmc   +2 more sources

Mitofusin 2-deficiency suppresses cell proliferation through disturbance of autophagy. [PDF]

PLoS ONE, 2015
Mitofusin2 (Mfn2), a mitochondrial outer membrane protein serving primarily as a mitochondrial fusion protein, has multiple functions in regulating cell biological processes. Defects of Mfn2 were found in diabetes, obesity, and neurodegenerative diseases.
Yanhong Ding, Han Gao, Lifang Zhao, Xian Wang, Ming Zheng   +4 more
doaj   +3 more sources

Mitofusin 2 in Mature Adipocytes Controls Adiposity and Body Weight [PDF]

Cell Reports, 2019
Summary: We found that exposure of adult animals to calorie-dense foods rapidly abolished expression of mitofusin 2 (Mfn2), a gene promoting mitochondrial fusion and mitochondrion-endoplasmic reticulum interactions, in white and brown fat.
Giacomo Mancini, Kevin Pirruccio, Xiaoyong Yang, Matthias Blücher, Matthew Rodeheffer, Tamas L. Horvath   +5 more
doaj   +4 more sources

Puerarin relives inflammation, bone destruction and facilitates osteogenic differentiation in periodontitis by enhancing mitochondrial autophagy via activating mitochondrial Mitofusin 2. [PDF]

Stem Cell Res Ther
Xiang Y, Li Z, He X, Chu X, Gao C, Guo J, Luan Y, Yang K, Zhang D.   +8 more
europepmc   +3 more sources

Prognostic impact of mitofusin 2 expression in colon cancer. [PDF]

Transl Cancer Res, 2022
Mitofusin 2 (MFN2) is involved in several biological processes, including cancer. MFN2 is downregulated in some types of cancer and inhibits cancer cell proliferation, migration, and invasion. However, the relationship between MFN2 and colon cancer remains unknown.In this study, MFN2 expression was investigated using The Cancer Genome Atlas (TCGA) and ...
Cheng X, Li Y, Liu F.
europepmc   +3 more sources