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Relationship between mitofusin 2 and cancer
2019Mitochondria are dynamic organelles whose actions are fundamental for cell viability. Within the cell, the mitochondrial system is incessantly modified via the balance between fusion and fission processes. Among other proteins, mitofusin 2 is a central protagonist in all these mitochondrial events (fusion, trafficking, contacts with other organelles ...
A. Allegra +3 more
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Mitofusin 2 tethers endoplasmic reticulum to mitochondria
Nature, 2008Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown. Here we show that mitofusin 2, a mitochondrial dynamin-related protein mutated in the inherited motor ...
de Brito OM, SCORRANO, LUCA
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Doxorubicin-induced cardiomyocyte apoptosis: Role of mitofusin 2
The International Journal of Biochemistry & Cell Biology, 2017Doxorubicin (DOX) is an anti-tumor agent that is widely used in clinical setting for cancer treatment. The application of the DOX, however, is limited by its cardiac toxicity which can induce heart failure through an undefined mechanism. Mitofusin 2 (Mfn2) is a mitochondrial GTPase fusion protein that is located on the outer membrane of mitochondria ...
Han, Tang +5 more
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Role of mitofusin 2 in cardiovascular oxidative injury
Journal of Molecular Medicine, 2010Mitochondria are highly dynamic organelles with constant shape changes regulated by fusion and fission events. In addition to regulating mitochondrial morphology, mitochondrial fusion/fission is involved in fundamental mitochondrial biological processes, including mitochondrial metabolism, energization, respiration, mitochondrial membrane potential ...
Ming, Zheng, Rui-Ping, Xiao
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Mitofusin 1 and Mitofusin 2 Function in the Context of Brain Development
2011Mitofusin 1 and 2 are outer-mitochondrial membrane proteins that have been shown to be involved in fusion. Mitofusin 2 has also been associated with apoptosis and development. When Mfn1 and Mfn2 were each conditionally knocked out from the cerebellum, Purkinje cells in Mfn2 deficient cerebellum during development had undergone neurodegeneration ...
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Mitofusin-2 Regulates Platelet Mitochondria and Function
Circulation ResearchBACKGROUND: Single-nucleotide polymorphisms linked with the rs1474868 T allele ( MFN2 [mitofusin-2] T/T) in the human mitochondrial fusion protein MFN2 gene are associated with reduced platelet MFN2 RNA expression and platelet ...
Shancy Jacob +27 more
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Structural Basis of Mitochondrial Tethering by Mitofusin Complexes
Science, 2004Vesicle fusion involves vesicle tethering, docking, and membrane merger. We show that mitofusin, an integral mitochondrial membrane protein, is required on adjacent mitochondria to mediate fusion, which indicates that mitofusin complexes act in trans (that is, between adjacent mitochondria).
Koshiba, Takumi +5 more
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IKKβ stabilizes Mitofusin 2 and suppresses doxorubicin cardiomyopathy
Cardiovascular ResearchAbstract Aims The mitochondrial dynamics protein Mitofusin 2 (MFN2) coordinates critical cellular processes including mitochondrial bioenergetics, quality control, and cell viability. The NF-κB kinase IKKβ suppresses mitochondrial injury in doxorubicin cardiomyopathy, but the underlying mechanism is ...
Matthew Guberman +6 more
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Research Progress of Mitofusin-2*
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2010Guang-Ju ZHAO +2 more
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