Results 221 to 230 of about 5,369 (241)

Role of mitofusin 2 in cardiovascular oxidative injury

Journal of Molecular Medicine, 2010
Mitochondria are highly dynamic organelles with constant shape changes regulated by fusion and fission events. In addition to regulating mitochondrial morphology, mitochondrial fusion/fission is involved in fundamental mitochondrial biological processes, including mitochondrial metabolism, energization, respiration, mitochondrial membrane potential ...
Ming, Zheng, Rui-Ping, Xiao
openaire   +2 more sources

Mitofusin 1 and Mitofusin 2 Function in the Context of Brain Development

2011
Mitofusin 1 and 2 are outer-mitochondrial membrane proteins that have been shown to be involved in fusion. Mitofusin 2 has also been associated with apoptosis and development. When Mfn1 and Mfn2 were each conditionally knocked out from the cerebellum, Purkinje cells in Mfn2 deficient cerebellum during development had undergone neurodegeneration ...
openaire   +2 more sources

Structural Basis of Mitochondrial Tethering by Mitofusin Complexes

Science, 2004
Vesicle fusion involves vesicle tethering, docking, and membrane merger. We show that mitofusin, an integral mitochondrial membrane protein, is required on adjacent mitochondria to mediate fusion, which indicates that mitofusin complexes act in trans (that is, between adjacent mitochondria).
Koshiba, Takumi, Detmer, Scott A., Kaiser, Jens T., Chen, Hsiuchen, McCaffery, J. Michael, Chan, David C.   +5 more
openaire   +3 more sources

Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling

Science Signaling, 2009
A protein that mediates mitochondrial fusion also suppresses innate immune responses to viral infection.
Kai, Yasukawa, Hiroyuki, Oshiumi, Makoto, Takeda, Naotada, Ishihara, Yusuke, Yanagi, Tsukasa, Seya, Shun-ichiro, Kawabata, Takumi, Koshiba   +7 more
openaire   +2 more sources

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

Nature, 2008
Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown. Here we show that mitofusin 2, a mitochondrial dynamin-related protein mutated in the inherited motor ...
de Brito OM, SCORRANO, LUCA
openaire   +4 more sources

The Role of Mitofusins in the Osteoclast Lineage

2019
Mitochondria exist in a highly dynamic network in many cell types, and mutations in mitochondrial transmembrane GTPase mitofusin2 (MFN2), a key factor that mediates mitochondrial tethering, cause defects in the nervous system. Intriguingly, the skeleton has been overlooked in patients with such mutations.
openaire   +2 more sources

Mitofusin-2 Regulates Platelet Mitochondria and Function

Circulation Research
BACKGROUND: Single-nucleotide polymorphisms linked with the rs1474868 T allele ( MFN2 [mitofusin-2] T/T) in the human mitochondrial fusion protein MFN2 gene are associated with reduced platelet MFN2 RNA expression and platelet ...
Shancy Jacob, Yasuhiro Kosaka, Seema Bhatlekar, Frederik Denorme, Haley Benzon, Alexandra Moody, Victoria Moody, Emilia A. Tugolukova, Grayson Hull, Nina Kishimoto, Bhanu K. Manne, Li Guo, Rhonda Souvenir, Brayden J. Seliger, Alicia S. Eustes, Kelly Hoerger, Neal D. Tolley, Amir N. Fatahian, Sihem Boudina, David C. Christiani, Yongyue Wei, Can Ju, Robert A. Campbell, Matthew T. Rondina, E. Dale Abel, Paul F. Bray, Andrew S. Weyrich, Jesse W. Rowley   +27 more
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From dynamin related proteins structures and oligomers to membrane fusion mediated by mitofusins

Biochimica Et Biophysica Acta - Bioenergetics, 2022
Mickael M Cohen
exaly  

Deubiquitylating mitofusin

Nature Reviews Molecular Cell Biology, 2013
openaire   +1 more source

Research Progress of Mitofusin-2*

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2010
Guang-Ju ZHAO, Zhong-Qiu LU, Yong-Ming YAO   +2 more
openaire   +1 more source