Results 11 to 20 of about 227,000 (310)

The role of phosphatidylinositide‐3‐kinase in basal mitogen‐activated protein kinase activity and cell survival [PDF]

FEBS Letters, 1999
Phosphatidylinositide‐3‐OH‐kinase (PI 3‐kinase) is an upstream activator of p42/p44 mitogen‐activated protein kinase (MAPK), but the role of PI 3‐kinase‐dependent MAPK remains obscure. Here we demonstrate that in a variety of different cell types, PI 3‐kinase inhibition results in an inhibition of MAPK in unstimulated cells but does not interfere with ...
Henri H. Versteeg, Maaike EVERTZEN, Sander J. H. van Deventer, Maikel P. Peppelenbosch   +3 more
openalex   +3 more sources

Knockdown of Mitogen-Activated Protein Kinase Kinase 3 Negatively Regulates Hepatitis A Virus Replication [PDF]

International Journal of Molecular Sciences, 2021
Zinc chloride is known to be effective in combatting hepatitis A virus (HAV) infection, and zinc ions seem to be especially involved in Toll-like receptor (TLR) signaling pathways. In the present study, we examined this involvement in human hepatoma cell lines using a human TLR signaling target RT-PCR array.
Tatsuo Kanda, Reina Sasaki-Tanaka, Ryota Masuzaki, Naoki Matsumoto, Hiroaki Okamoto, Mitsuhiko Moriyama   +5 more
openaire   +2 more sources

Regulation of GATA-2 Phosphorylation by Mitogen-activated Protein Kinase and Interleukin-3 [PDF]

Journal of Biological Chemistry, 1995
GATA-2 is a member of a family of transcription factors which bind a common DNA sequence motif (WGA-TAR) through an evolutionarily conserved zinc finger domain. An essential role for GATA-2 in the development of hematopoietic stem cells has recently been shown in gene targeting experiments in mice.
Masayuki Towatari, Gillian May, Richard Marais, Gordon R. Perkins, Christopher J. Marshall, Sally A. Cowley, Tariq Enver   +6 more
openalex   +5 more sources

Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3 [PDF]

Journal of Biological Chemistry, 2017
The kinase p38α MAPK (p38α) plays a pivotal role in many biological processes. p38α is activated by canonical upstream kinases that phosphorylate the activation region. The purpose of our study was to determine whether such activation may depend on redox-sensing cysteines within p38α.
Bassi, Rekha, Burgoyne, Joseph R, DeNicola, Gian F, Rudyk, Olena, DeSantis, Vittorio, Charles, Rebecca L, Eaton, Philip, Marber, Michael S   +7 more
openaire   +5 more sources

Post-infarction remodeling is independent of mitogen-activated protein kinase kinase 3 (MKK3) [PDF]

Cardiovascular Research, 2007
Our aim was to examine the role of mitogen-activated protein kinase kinase 3 (MKK3) in the development of left ventricular (LV) remodeling following myocardial infarction (MI).MKK3-null mice were subjected to permanent coronary artery ligation. Twenty-eight days after MI, haemodynamics in male mkk3+/+(WT) and mkk3-/-(KO) littermates were assessed using
Clark, J, Flavell, R, Faircloth, M, Davis, R, Heads, R, Marber, M   +5 more
openaire   +4 more sources

MAPK3 (mitogen-activated protein kinase 3) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on MAPK3 (mitogen-activated protein kinase 3), with data on DNA, on the protein encoded, and where the gene is implicated.
Tuncay, S, Banerjee, S
openaire   +2 more sources

Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinoma

Cell Death and Disease, 2022
Esophageal squamous cell carcinoma (ESCC) is one of the world’s leading causes of death, and its primary clinical therapy relies on surgical resection, chemotherapy, radiotherapy, and chemoradiotherapy.
Zhen-Yuan Zheng, Man-Yu Chu, Wan Lin, Ya-Qi Zheng, Xiu-E Xu, Yang Chen, Lian-Di Liao, Zhi-Yong Wu, Shao-Hong Wang, En-Min Li, Li-Yan Xu   +10 more
doaj   +1 more source

SHIP2 inhibition alters redox‐induced PI3K/AKT and MAP kinase pathways via PTEN over‐activation in cervical cancer cells

FEBS Open Bio, 2020
Phosphatidylinositol (3,4,5)‐trisphosphate (PI(3,4,5)P3) is required for protein kinase B (AKT) activation. The level of PI(3,4,5)P3 is constantly regulated through balanced synthesis by phosphoinositide 3‐kinase (PI3K) and degradation by ...
Abdelhalim Azzi
doaj   +1 more source

Mitogen-Activated Protein Kinase Kinase 3 Regulates Seed Dormancy in Barley [PDF]

Current Biology, 2016
Seed dormancy has fundamental importance in plant survival and crop production; however, the mechanisms regulating dormancy remain unclear [1-3]. Seed dormancy levels generally decrease during domestication to ensure that crops successfully germinate in the field.
Nakamura, S, Pourkheirandish, M, Morishige, H, Kubo, Y, Nakamura, M, Ichimura, K, Seo, S, Kanamori, H, Wu, J, Ando, T, Hensel, G, Sameri, M, Stein, N, Sato, K, Matsumoto, T, Yano, M, Komatsuda, T   +16 more
openaire   +3 more sources

In Pursuit: A Mother’s Account of Her Son’s Rare Disease Diagnosis Journey

Journal of Patient-Centered Research and Reviews, 2021
A personal account from a mother’s perspective on her undiagnosed son’s medical journey over almost 6 years toward a diagnosis of a rare genetic variant in mitogen-activated protein kinase 8 interacting protein 3 (MAPK8IP3) resulting in neurodevelopment ...
Anne M. Jones
doaj   +1 more source