Results 261 to 270 of about 96,831 (392)

Mediterranean Versus Western Diet Effects on Obesity Phenotypes and Adipose Tissue Transcriptional Profiles in Female Monkeys

Obesity, EarlyView.
ABSTRACT Objective Obesity, or excessive body fat, is a significant health risk factor. Western diets (WD) contribute to metabolic dysfunction and obesity, while Mediterranean diets (MD) improve metabolic health. This study examined the contrasting effects of WD versus MD on visceral and subcutaneous adipose tissues (VAT, SAT) using a randomized ...
Aya Jamal Abusheikha, Corbin S. C. Johnson, Noah Snyder‐Mackler, Kip D. Zimmerman, Brett M. Frye, Carol A. Shively, Thomas C. Register   +6 more
wiley   +1 more source

Combined Loss of Obsc and Obsl1 in Murine Hearts Results in Diastolic Dysfunction, Altered Metabolism, and Deregulated Mitophagy

Kyohei Fujita, Patrick Desmond, Jordan Blondelle, Matúš Soták, Meenu Rohini Rajan, Madison Clark, É. Estève, Yunghang Chan, Yusu Gu, Virginia Actis Dato, Valeria Marrocco, Nancy D. Dalton, Majid Ghassemian, Aryanne Do, M Kłos, Kirk L. Peterson, Farah Sheikh, Yoshitake Cho, Emma Börgeson, Stephan Lange   +19 more
openalex   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Unraveling the role of mitochondrial dysfunction in diabetic kidney disease: insights and interventions. [PDF]

Front Pharmacol
Fan Z, Luo P, Gao Y, Ma H, Fan J, Sanan S, Zhang P, Lu K, Xia H.   +8 more
europepmc   +1 more source

GSK-3α-BNIP3 axis promotes mitophagy in human cardiomyocytes under hypoxia [PDF]

Hezlin Marzook, Anamika Gupta, Manju Nidagodu Jayakumar, Mohamed A. Saleh, Dhanendra Tomar, Rizwan Qaisar, Firdos Ahmad   +6 more
openalex   +1 more source

Lipid Nanoparticles Delivering ClpP‐mRNA Suppress Pyroptosis and Senescence in Intervertebral Disc Degeneration via mTOR/BNIP3‐Activated Mitophagy

Rare Metals, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang, Zhiqiang Wang, Tong Zhang, Shicheng Qiu, Guang Yang, Yanzheng Gao, Xiaofeng Lian, Xin Peng   +7 more
wiley   +1 more source

Microtubule affinity-regulating kinase 4 exacerbates diabetic cardiomyopathy by inhibiting UNC-51-like kinase 1-mediated mitochondrial autophagy. [PDF]

World J Diabetes
Wu Y, Wang WY, Zhang JQ, Wang S, Zeng Z, Fu L, Li B.   +6 more
europepmc   +1 more source

Mitochondrial Dysfunction and Mitophagy in Parkinson's Disease: From Mechanism to Therapy.

TIBS -Trends in Biochemical Sciences. Regular ed, 2020
A. Malpartida, M. Williamson, Derek P. Narendra, R. Wade-Martins, B. Ryan   +4 more
semanticscholar   +1 more source

Melatonin ameliorates intervertebral disc degeneration via the potential mechanisms of mitophagy induction and apoptosis inhibition [PDF]

, 2019
Yu Chen, Yanqing Wu, Hongxue Shi, Jianle Wang, Zengming Zheng, Jian Chen, Xi-Bang Chen, Zengjie Zhang, Daoliang Xu, Xiangyang Wang, Jian Xiao   +10 more
openalex   +1 more source

Bridging the Effects of Noncontact Temperature Sensing and Cellular Biofunctionality in Nanosized Dysprosium(III)‐Doped Fluorapatite

Small, EarlyView.
Multifunctional dysprosium(III) ion–doped fluorapatite nanomaterials combine bioactivity with photoluminescent temperature sensing. The biological studies reveal interactions with progenitor cells, highlighting potential applications in regenerative medicine and tissue engineering, while temperature‐dependent emission of Dy³⁺ ions enables reliable ...
Sara Targonska, Natalia Charczuk, Adam Kabanski, Klaudia Marcinkowska, Joanna Sulecka‐Zadka, Daria Szymanowska, Agnieszka Śmieszek, Rafal J. Wiglusz   +7 more
wiley   +1 more source