Results 61 to 70 of about 96,831 (392)
EMBO Journal, 2023 Mitophagy is a fundamental quality control mechanism of mitochondria. Its regulatory mechanisms and pathological implications remain poorly understood.
Yu Cao +14 more
semanticscholar +1 more source
Metabolic control of mitophagy
European Journal of Clinical Investigation, 2023 AbstractMitochondrial dysfunction is a major hallmark of ageing and related chronic disorders. Controlled removal of damaged mitochondria by the autophagic machinery, a process known as mitophagy, is vital for mitochondrial homeostasis and cell survival.
Zimmermann, Andreas +6 more
openaire +2 more sources
Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy
Redox Biology, 2020 Both iron metabolism and mitophagy, a selective mitochondrial degradation process via autolysosomal pathway, are fundamental for the cellular well-being.
Hao Wu +8 more
doaj +1 more source
Mitophagy in neurodegeneration and aging [PDF]
Frontiers in Genetics, 2012 Macroautophagy is a cellular catabolic process that involves the sequestration of cytoplasmic constituents into double-membrane vesicles known as autophagosomes, which subsequently fuse with lysosomes, where they deliver their cargo for degradation. The main physiological role of autophagy is to recycle intracellular components, under conditions of ...
Palikaras, Konstantinos +1 more
openaire +3 more sources
Mitophagy in Antiviral Immunity [PDF]
Frontiers in Cell and Developmental Biology, 2021 Mitochondria are important organelles whose primary function is energy production; in addition, they serve as signaling platforms for apoptosis and antiviral immunity. The central role of mitochondria in oxidative phosphorylation and apoptosis requires their quality to be tightly regulated.
Hongna Wang +8 more
openaire +3 more sources
TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control [PDF]
, 2014 The 18-kDa TSPO (translocator protein) localizes on the outer mitochondrial membrane (OMM) and participates in cholesterol transport. Here, we report that TSPO inhibits mitochondrial autophagy downstream of the PINK1-PARK2 pathway, preventing essential ...
Anholt R +22 more
core +3 more sources
Unconventional Initiation of PINK1/Parkin Mitophagy by Optineurin
bioRxiv, 2023 Cargo sequestration is a fundamental step of selective autophagy in which cells generate a double membrane structure termed an autophagosome on the surface of cargoes.
T. Nguyen +11 more
semanticscholar +1 more source
Chronic heart failure is characterized by altered mitochondrial function and structure in circulating leucocytes [PDF]
, 2018 Oxidative stress is currently viewed as a key factor in the genesis and progression of Heart Failure (HF). The aim of this study was to characterize the mitochondrial changes linked to oxidative stress generation in circulating peripheral blood ...
Coluccia, Roberta +12 more
core +1 more source
Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging
Nature CommunicationsDysregulated autophagy and mitochondrial function are two well-described hallmarks of aging. Here, the authors describe an unexpected age-associated upregulation of mitophagy in response to neuroinflammation triggered by leaked mtDNA.
Juan Ignacio Jiménez-Loygorri +10 more
semanticscholar +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009 Concurrent mitochondrial elimination and autophagy in many systems has led to the proposal that autophagy is the main mechanism of mitochondrial turnover during development and under pathological conditions. The term mitophagy was coined to describe the selective removal of mitochondria by autophagy but the process itself is still contentious.
openaire +2 more sources