Results 21 to 30 of about 229,134 (290)
IEEE Access, 2020 Detection of mitotic tumor cells per tissue area is one of the critical markers of breast cancer prognosis. The aim of this paper is to develop a method for the automatic detection of mitotic figures from breast cancer histological slides using a ...
Meriem Sebai +2 more
doaj +1 more source
Vimentin filaments interact with the actin cortex in mitosis allowing normal cell division
Nature Communications, 2019 The vimentin network displays remarkable plasticity to support basic cellular functions and reorganizes during cell division. Here, we show that in several cell types vimentin filaments redistribute to the cell cortex during mitosis, forming a robust ...
Sofia Duarte +5 more
semanticscholar +1 more source
An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis
Molecules and Cells, 2019 Summary Since nuclear envelope breakdown occurs during mitosis in metazoan cells, it has been proposed that macroautophagy must be inhibited to maintain genome integrity.
Richard I. Odle +9 more
semanticscholar +1 more source
Closed mitosis requires local disassembly of the nuclear envelope
bioRxiv, 2019 At the end of mitosis, eukaryotic cells must segregate the two copies of their replicated genome into two new nuclear compartments 1 . They do this either by first dismantling and later reassembling the nuclear envelope in an ‘open mitosis’ or by ...
Gautam Dey +5 more
semanticscholar +1 more source
Cigarette smoke condensate induces centrosome clustering in normal lung epithelial cells
Cancer Medicine, 2023 Background Unlike normal cells, cancer cells frequently have multiple centrosomes that can cluster to form bipolar mitotic spindles and allow for successful cell division.
Jose Thaiparambil +4 more
doaj +1 more source
Mechanisms of Chromosome Congression during Mitosis
Biology, 2017 Chromosome congression during prometaphase culminates with the establishment of a metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more than 100 years of research on this topic have attempted to explain chromosome ...
H. Maiato +3 more
semanticscholar +1 more source
IEEE AccessAt present, mitosis detection in breast histopathology images is a critical issue for breast cancer grading. Due to the breast tissue having a complex structure, and mitosis and non-mitosis cells being similar to each other, traditional methods for ...
Sarah Ayashm +3 more
doaj +1 more source
Fcp1 phosphatase controls Greatwall kinase to promote PP2A-B55 activation and mitotic progression
eLife, 2015 During cell division, progression through mitosis is driven by a protein phosphorylation wave. This wave namely depends on an activation-inactivation cycle of cyclin B-dependent kinase (Cdk) 1 while activities of major protein phosphatases, like PP1 and ...
Rosa Della Monica +4 more
doaj +1 more source
PLK1 Activation in Late G2 Sets Up Commitment to Mitosis.
Cell Reports, 2017 Commitment to mitosis must be tightly coordinated with DNA replication to preserve genome integrity. While we have previously established that the timely activation of CyclinB1-Cdk1 in late G2 triggers mitotic entry, the upstream regulatory mechanisms ...
Lilia Gheghiani +4 more
semanticscholar +1 more source
A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression
Cell Reports, 2021 Summary: Mitochondria are highly dynamic organelles subjected to fission and fusion events. During mitosis, mitochondrial fission ensures equal distribution of mitochondria to daughter cells. If and how this process can actively drive mitotic progression
Evanthia Pangou +15 more
doaj +1 more source