Results 21 to 30 of about 386,071 (373)

Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity [PDF]

, 2007
Faithful chromosome segregation in mitosis requires the formation of a bipolar mitotic spindle with stably attached chromosomes. Once all of the chromosomes are aligned, the connection between the sister chromatids is severed by the cysteine protease ...
Gruneberg, Ulrike, Kleylein-Sohn, Julia, Nigg, Erich A., Thein, Kerstin H.   +3 more
core   +3 more sources

Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates. [PDF]

, 2017
As microtubule-organizing centers of animal cells, centrosomes guide the formation of the bipolar spindle that segregates chromosomes during mitosis.
Antkowiak, Mark, Brust-Mascher, Ingrid, Castro, Noemi M, Cheung, Lee, Christensen, Lana N, Huang, Bo, Jao, Li-En, Jiang, Xueer, Mahe, Karan, Ou, Tingyoung, Sepulveda, Guadalupe, Yoon, Daniel   +11 more
core   +2 more sources

Single-Cell Dynamic Analysis of Mitosis in Haploid Embryonic Stem Cells Shows the Prolonged Metaphase and Its Association with Self-diploidization

Stem Cell Reports, 2017
The recent establishment of mammalian haploid embryonic stem cells (ESCs) provides new possibilities for genetic screening and for understanding genome evolution and function. However, the dynamics of mitosis in haploid ESCs is still unclear.
Ao Guo, Shichao Huang, Jiali Yu, Huihan Wang, Haisen Li, Gang Pei, Li Shen   +6 more
doaj   +1 more source

Chromatin proteins and RNA are associated with DNA during all phases of mitosis. [PDF]

, 2016
Mitosis brings about major changes to chromosome and nuclear structure. We used recently developed proximity ligation assay-based techniques to investigate the association with DNA of chromatin-associated proteins and RNAs in Drosophila embryos during ...
Brock, Hugh W, Caplan, Jeffrey L, Fenstermaker, Tyler K, Hodgson, Jacob W, L Black, Kathryn, Mazo, Alexander, Petruk, Svetlana   +6 more
core   +3 more sources

DNA damage induced during mitosis undergoes DNA repair synthesis. [PDF]

, 2020
Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by DNA repair deficiencies.
Berns, Michael W, Cohen, Shirli, Gomez Godinez, Veronica, Kabbara, Sami, Kong, Xiangduo, Maravillas-Montero, Jose Luis, Preece, Daryl, Sherman, Adria, Shi, Zhixia, Wu, Tao, Yokomori, Kyoko   +10 more
core   +1 more source

Exotic mitotic mechanisms [PDF]

, 2012
The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope.
Drechsler, Hauke, McAinsh, Andrew D.
core   +1 more source

Differential expression of conserved germ line markers and delayed segregation of male and female primordial germ cells in a hermaphrodite, the leech helobdella. [PDF]

, 2013
In sexually reproducing animals, primordial germ cells (PGCs) are often set aside early in embryogenesis, a strategy that minimizes the risk of genomic damage associated with replication and mitosis during the cell cycle.
Cho, Sung-Jin, Vallès, Yvonne, WEISBLAT, David A.   +2 more
core   +2 more sources

Automated mitosis detection using texture, SIFT features and HMAX biologically inspired approach

Journal of Pathology Informatics, 2013
Context: According to Nottingham grading system, mitosis count in breast cancer histopathology is one of three components required for cancer grading and prognosis. Manual counting of mitosis is tedious and subject to considerable inter- and intra-reader
Humayun Irshad, Sepehr Jalali, Ludovic Roux, Daniel Racoceanu, Lim Joo Hwee, Gilles Le Naour, Frédérique Capron   +6 more
doaj   +1 more source

Mitosis Methods & Protocols

European Journal of Histochemistry, 2010
Mitosis Methods & Protocols Andrew D. McAinsh (Edt) Humana press, Totowa, New Jersey (USA) Series: Springer Protocols Methods in Molecular Biology, Volume 545, 2009 ISBN: 978-1-60327-992-5   It is quite clear from the contents of this book that
CarloAlberto Redi
doaj   +1 more source

Single-cell monitoring of dry mass and dry mass density reveals exocytosis of cellular dry contents in mitosis

eLife, 2022
Cell mass and composition change with cell cycle progression. Our previous work characterized buoyant mass dynamics in mitosis (Miettinen et al., 2019), but how dry mass and cell composition change in mitosis has remained unclear.
Teemu P Miettinen, Kevin S Ly, Alice Lam, Scott R Manalis   +3 more
doaj   +1 more source