Results 191 to 200 of about 205,638 (297)

Merkel cell carcinoma: an updated guide for pathologists

Histopathology, EarlyView.
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma for which the differential diagnosis can include other small cell malignancies (especially metastatic small cell carcinoma) or cutaneous carcinoma. Morphologic and immunophenotypic aberrancies in MCC can increase diagnostic challenge.
Paul W. Harms
wiley   +1 more source

Mechanical Coupling With the Nuclear Envelope Shapes the Schizosaccharomyces pombe Mitotic Spindle. [PDF]

Cytoskeleton (Hoboken)
Begley MA, Mahoney T, Medina CP, Zareiesfandabadi P, Rapp MB, Tirfe M, LeBlanc SJ, Betterton MD, Elting MW.   +8 more
europepmc   +1 more source

Novel and emerging cutaneous soft tissue tumours

Histopathology, EarlyView.
This review outlines the defining histopathological, immunophenotypic and molecular features of novel and emerging cutaneous soft tissue tumours, including hybrid superficial ALK‐rearranged myxoid spindle cell neoplasm/epithelioid fibrous histiocytoma, superficial neurocristic tumour, ALK‐rearranged epithelioid vascular neoplasm and MITF pathway ...
Saba Shafi, Josephine K Dermawan
wiley   +1 more source

Detection of NTRK1/2/3 rearrangements in pigmented spindle cell naevus of Reed: a comparative study of optimized pan‐TRK immunohistochemistry, FISH and RNA‐NGS

Histopathology, EarlyView.
Pigmented spindle cell nevus of Reed (PSCN) is a subtype of Spitz nevus mainly characterized by MYO5A::NTRK3 fusion. Our optimized pan‐TRK protocol stained 16/79 (20.3%) PSCNs (diffuse, granular, cytoplasmic staining of moderate intensity) and revealed high values of specificity (94.4%–96.2%) and positive predictive value (92.3%) for the detection of ...
Costantino Ricci, Barbara Corti, Sara Coluccelli, Giulia Calafato, Debora Anconelli, Francesco Vasuri, Martina Lambertini, Federico Venturi, Biagio Scotti, Alessia Grillini, Eugenia Franchini, Thais Maloberti, Antonio De Leo, Giovanni Tallini, Elisa Gruppioni, Annalisa Altimari, Michelangelo Fiorentino, Gerardo Cazzato, Emi Dika, Dario de Biase   +19 more
wiley   +1 more source

PLAG1‐rearranged paediatric fibromyxoid tumour: clinicopathological, molecular and epigenetic analysis of 10 cases supporting a morphological spectrum with lipoblastoma

Histopathology, EarlyView.
P‐FMT histologically resembles fibroblastic lipoblastoma and has similar gene fusions, DNA methylation profiles, and benign clinical behaviour, supporting classification of P‐FMT as a morphological variant of lipoblastoma. Aim Paediatric PLAG1‐rearranged fibromyxoid tumour (P‐FMT) is an emerging soft‐tissue neoplasm characterized by predominantly ...
Faizan Malik, Selene C Koo, Quynh T Tran, Carina A Dehner, Robert E Ruiz, Meera Hameed, Anthony Arnoldo, Robert Siddaway, Brent A Orr, Rose Chami   +9 more
wiley   +1 more source

19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism. [PDF]

Cell Rep
Marescal O, Cheeseman IM.
europepmc   +1 more source

Plaque‐type trichoblastoma and its siblings: A (follicular tumour) family history

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Ines Bertlich, Ferdinand Toberer, Tilman Schulz, Dmitry V. Kazakov, Wolfgang Hartschuh   +4 more
wiley   +1 more source

From observation to understanding: A multi‐agent framework for smart microscopy

Journal of Microscopy, EarlyView.
Abstract Smart microscopy represents a paradigm shift in biological imaging, moving from passive observation tools to active collaborators in scientific inquiry. Enabled by advances in automation, computational power, and artificial intelligence, these systems are now capable of adaptive decision‐making and real‐time experimental control.
P. S. Kesavan, Pontus Nordenfelt
wiley   +1 more source

HDAC6 deacetylates ENKD1 to regulate mitotic spindle behavior and corneal epithelial homeostasis. [PDF]

EMBO Rep
Song T, Han X, Yin H, Zhao J, Ma M, Wen X, Liu C, Yue Y, Zhao H, Zhou J, Yang Y, Ran J, Liu M.   +12 more
europepmc   +1 more source

Transcriptome Analysis Reveals Distinct Molecular Signatures Between Erosive and Non‐Erosive Oral Lichen Planus

Oral Diseases, EarlyView.
ABSTRACT Objectives To identify molecular mechanisms distinguishing the erosive subtype of oral lichen planus (EOLP) from the non‐erosive subtype (NEOLP) through transcriptomic analysis. Methods We analysed bulk RNA‐seq data from 30 buccal mucosa samples (13 EOLP, 17 NEOLP) using differential expression, Gene Set Enrichment Analysis (GSEA ...
Kisung Sheen, Chaerim Song, Kanghyun Kwon, Seoyeon Kim, Hye‐Ji Park, Man S. Kim   +5 more
wiley   +1 more source