Results 211 to 220 of about 130,672 (286)

Identification of novel FGFR2::TXLNB Fusion in a polymorphous low‐grade neuroepithelial tumor of the young

Brain Pathology, Volume 36, Issue 3, May 2026.
We report a novel FGFR2::TXLNB fusion in a child with hippocampal PLNTY. This fusion likely drives tumorigenesis via homodimerization and activation of MAPK/PI3K pathways, expanding PLNTY's molecular spectrum and suggesting a potential therapeutic target.
Sha‐Sha Hu, Tian‐Yuan Tan, Wei Yan, Bo Wang   +3 more
wiley   +1 more source

FAM110A promotes mitotic spindle formation by linking microtubules with actin cytoskeleton. [PDF]

Proc Natl Acad Sci U S A
Aquino-Perez C, Safaralizade M, Podhajecky R, Wang H, Lansky Z, Grosse R, Macurek L.   +6 more
europepmc   +1 more source

Acral Mesenchymal Spindle Cell Neoplasm With a Novel HMGA2::NCOA2 Fusion

Journal of Cutaneous Pathology, Volume 53, Issue 5, Page 402-406, May 2026.
ABSTRACT Molecular profiling has revolutionized the field of soft tissue pathology, enhancing diagnostic precision and treatment strategies. The integration of molecular analysis and immunohistochemistry has been crucial for classifying diagnostically challenging acral mesenchymal neoplasms.
Grace Z. Armstrong, Carina A. Dehner, Eitan Halper‐Stromberg, Esther Baranov, Anna C. Eden, Rachel P. Kowal   +5 more
wiley   +1 more source

Atypical Fibroxanthoma/Pleomorphic Dermal Sarcoma With Osseous Metaplasia: A Series of Three Cases

Journal of Cutaneous Pathology, Volume 53, Issue 5, Page 407-413, May 2026.
ABSTRACT Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) are rare mesenchymal tumors typically arising on sun‐damaged skin of the head and neck in elderly patients. PDS is a more aggressive tumor but with similar demographics, cellular morphology, immunohistochemical features, and genetic findings.
Taylor Novice, Yitong Xu, Thomas Brenn, Scott C. Bresler   +3 more
wiley   +1 more source

Functional Role of COP1 Gene in Hepatocellular Carcinoma Lipid Metabolism and Stemness

Genes to Cells, Volume 31, Issue 3, May 2026.
COP1 promotes HCC lipid metabolism and stemness via the functional interaction with AKR1D1 and TMEM65 genes, respectively, indicating its potential as a therapeutic target for treating primary HCC and preventing metastasis and/or recurrence. ABSTRACT We have previously defined the constitutive photomorphogenic protein 1 (COP1) gene as a therapeutic ...
Eun‐Hye Jeon, An‐Na Bae, Hajin Lee, Keon Uk Park, Hyun Mu Shin, Jong Ho Park, Kwang Seok Kim, In‐Chul Park, Yun‐Han Lee   +8 more
wiley   +1 more source

Trisoxazole Macrolides Potentiate the Microtubule Assembly and Antimitotic Activities of Taxanes

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
Photoaffinity experiments identified tubulin as a new target of mycalolides. Though weakly cytotoxic, the trisoxazole macrolactone moiety enhanced paclitaxel's microtubule assembly and antimitotic effects. Molecular modeling studies suggested that MyC stabilizes α/β‐tubulin heterodimer interactions.
Shohei Ebihara, Rio Takaiso, Shota Kawaguchi, Atsunori Oshima, Masaki Kita   +4 more
wiley   +2 more sources

Farnesoid x Receptor Deficiency Promotes Hepatocytic Injury in Cyp2c70‐Deficient Mice With a Human‐Like Bile Acid Composition

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background and Aims Loss‐of‐function mutations in bile acid (BA)‐activated farnesoid x receptor (FXR/NR1H4) cause severe neonatal liver pathology in humans, earlier referred to as progressive familial intrahepatic cholestasis type 5 (PFIC5). However, Fxr‐deficient mice do not develop early‐onset liver disease, possibly due to the predominance ...
Hilde D. de Vries, Jinxiao Li, Kirill Ustyantsev, Milaine V. Hovingh, Niels L. Mulder, Rick Havinga, Anna Palmiotti, Krisztina de Bruyn, Brecht Attema, Ellen Weersing, Rachel E. Thomas, Vincent W. Bloks, Eugene Berezikov, Martijn van Faassen, Henkjan J. Verkade, Jan Freark de Boer, Folkert Kuipers   +16 more
wiley   +1 more source

Antiparallel microtubule bundling supports KIF15-driven mitotic spindle assembly. [PDF]

Mol Biol Cell
Salazar BM, Ohi R.
europepmc   +1 more source

CT Features of an Extraskeletal Osteosarcoma Associated With a Retained Surgical Sponge in a Dog

Veterinary Radiology &Ultrasound, Volume 67, Issue 3, May 2026.
ABSTRACT An 8‐year‐old neutered female Labradoodle presented with acute restlessness and inability to stand. Point‐of‐care ultrasound revealed a large abdominal mass, prompting further imaging. Computed tomography (CT) demonstrated a mass with marked mineralization, a thick, enhancing rim, and signs of intra‐abdominal dissemination.
Kota Yamashita, Misaki Osuga, Shouta Nouchi, Manabu Kurihara   +3 more
wiley   +1 more source

Dissipatively Fueled Unidirectionally Communicating DNA Circuits That Control Biocatalysis

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
Unidirectionally communicating, out‐of‐equilibrium DNA circuits are used to control enzyme activity. Transient DNAzyme activation generates fuel for temporal trypsin activation. Cyclic fuel‐driven hybridization and exonuclease‐mediated reset enable precise control over lifetimes, which is analyzed using combined experimental and computational ...
Philippe Jung, Daniel Felder, Gurudas Chakraborty, Tim Seifert, Matthias Wessling, Lifei Zheng, Andreas Herrmann   +6 more
wiley   +2 more sources