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Automated mitotic spindle hotspot counts are highly associated with clinical outcomes in systemically untreated early-stage triple-negative breast cancer. [PDF]

open access: yesNPJ Breast Cancer
Leon-Ferre RA   +14 more
europepmc   +1 more source
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Clathrin in mitotic spindles

American Journal of Physiology-Cell Physiology, 2000
Subconfluent cultures of Madin-Darby canine kidney (MDCK) and CV-1 cells were immunostained with two monoclonal antibodies (MAbs), MAb X-22 and MAb 23, against clathrin heavy chain and with polyclonal antiserum against a conserved region of all mammalian clathrin light chains.
C T, Okamoto, J, McKinney, Y Y, Jeng
openaire   +2 more sources

Theory of Mitotic Spindle Oscillations

Physical Review Letters, 2005
During unequal cell division the mitotic spindle is positioned away from the center of the cell before cell cleavage. In many biological systems this repositioning is accompanied by oscillatory movements of the spindle. We present a theoretical description for mitotic spindle oscillations.
Grill, S., Kruse, K., Jülicher, F.
openaire   +4 more sources

Imaging the Mitotic Spindle

2012
The mitotic spindle, due to its striking form, has been imaged for well over 100 years. Composed largely of microtubules and chromosomes, the spindle also contains numerous proteins whose roles include biochemical and biophysical regulation of mitosis.
Paul S, Maddox   +6 more
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Mitotic spindle pole separation

Trends in Cell Biology, 1993
Eukaryotic cells utilize a microtubular spindle to segregate chromosomes during mitosis. Chromosome segregation requires the timely separation of the mitotic spindle poles to which the chromosomes are attached. Recent studies at the molecular and cellular levels have provided new insights into the mechanism and regulation of this process.
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Control of Mitotic Spindle Length

Annual Review of Cell and Developmental Biology, 2010
The mitotic spindle accurately segregates genetic instructions by moving chromosomes to spindle poles (anaphase A) and separating the poles (anaphase B) so that, in general, the chromosomes and poles are positioned near the centers of the nascent daughter cell products of each cell division.
Gohta, Goshima, Jonathan M, Scholey
openaire   +2 more sources

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