Results 161 to 170 of about 16,176 (222)
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Effect of MK-801 on endogenous dopamine release in vivo
Brain Research, 1990The effect of MK-801 on striatal dopamine (DA) release was investigated by using an in vivo microdialysis technique in the freely moving rat. Systemic injection of MK-801 (0.25, 0.5, 1, 2 mg/kg, i.p.) reduced the extracellular level of DA significantly and produced no change in the level of 3,4-dihydroxyphenylacetic acid.
Kenichi Kashihara +2 more
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Characteristics of MK-801-induced locomotor sensitization
Biochemical and Biophysical Research Communications, 2023Repeated administration of drugs of abuse leads to progressively greater behavioral responses; this phenomenon is referred to as behavioral sensitization. MK-801 blocks the N-methyl-d-aspartate (NMDA) receptor and elicits behavioral sensitization. Ketamine and phencyclidine, are also NMDA antagonists and have well-documented abuse potential. This study
Gang Li, Shijie Xu, Ung Gu Kang
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Anesthesia & Analgesia, 2007
Previous studies have found that the local anesthetic/sodium channel blocker lidocaine decreased MAC by maximum amounts approximately equal to the decreases produced by dizocilpine (MK-801), a N-methyl-d-aspartate (NMDA) receptor antagonist. Blockade of sodium channels by inhaled anesthetics has been suggested as a possible cause for impairment of ...
Yi, Zhang +4 more
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Previous studies have found that the local anesthetic/sodium channel blocker lidocaine decreased MAC by maximum amounts approximately equal to the decreases produced by dizocilpine (MK-801), a N-methyl-d-aspartate (NMDA) receptor antagonist. Blockade of sodium channels by inhaled anesthetics has been suggested as a possible cause for impairment of ...
Yi, Zhang +4 more
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Behavioral effects of MK-801 in the rat
Psychopharmacology, 1990Several experiments were conducted to study the effects of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801, on learning and memory in the rat. Rats displayed impaired performance on several sensorimotor tests and appeared grossly intoxicated when treated IP with 0.2 mg/kg MK-801, but not when treated with lower doses (0.05 or
D F, Wozniak +4 more
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The role of MK-801 in sensitization to stimulants
Brain Research Reviews, 2001Behavioral responses to stimulants can be progressively and persistently enhanced by their repeated administration. This phenomenon, called behavioral sensitization, may underlie substance abuse, psychosis, recurrence in bipolar disorder, or other psychiatric problems.
S, Sripada +3 more
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Behavioural Pharmacology, 2013
This study investigated the effects of chronic neonatal blockade of N-methyl-D-aspartate (NMDA) receptors on NMDA and muscarinic acetylcholine receptor-mediated neurotransmission in adulthood. Rats neonatally treated chronically with MK-801/saline were tested for 40 min, at the age of 14-16 weeks, for locomotor activity in an open field immediately ...
Hiroki, Furuie +2 more
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This study investigated the effects of chronic neonatal blockade of N-methyl-D-aspartate (NMDA) receptors on NMDA and muscarinic acetylcholine receptor-mediated neurotransmission in adulthood. Rats neonatally treated chronically with MK-801/saline were tested for 40 min, at the age of 14-16 weeks, for locomotor activity in an open field immediately ...
Hiroki, Furuie +2 more
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Bupivacaine-Induced Convulsion is Suppressed by MK-801
Regional Anesthesia & Pain Medicine, 1998Background and Objectives Not only the facilitation of inhibitory synapses but also the suppression of excitatory synapses may be effective in treating convulsion induced by local anesthetics. The effects of MK-801, a N-methyl-D-aspartate (NMDA) receptor antagonist, on bupivacaine-induced convulsion and hemodynamic ...
T, Kasaba +3 more
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[3H]MK-801 binding in Alzheimer's disease
Neuroscience Letters, 1988The density of [3H]MK-801 binding sites was studied in homogenates prepared from different cortical regions of postmortem brains of Alzheimer patients and age matched controls. Highest number of binding sites for this noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor was in temporal pole (Brodmann area A-38) in both groups.
M M, Mouradian +3 more
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Neuroprotection by MK-801 in temperature maintained gerbils
Brain Research Bulletin, 1995Hypothermia reduces ischemic brain damage, confounding interpretation of the neuroprotective effects of drugs. Specifically, the neuroprotectant MK-801 has been shown to cause hypothermia. Some have claimed that when body temperature is maintained, MK-801 is not a neuroprotectant, whereas others claim it retains its neuroprotective activity. MK-801 was
C A, Hoffman, C A, Boast
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Amnesic effect of the novel anticonvulsant MK-801
Pharmacology Biochemistry and Behavior, 1988MK-801, a reported N-methyl-D-aspartate (NMDA) antagonist with affinity for the phencyclidine (PCP) receptor, injected intravenously in mice before a training trial in a passive avoidance procedure, produced a similar amnesic effect to that produced by the standard amnesic agent scopolamine.
M J, Benvenga, T C, Spaulding
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