Results 161 to 170 of about 24,407 (221)

MK-801 potently inhibits alcohol withdrawal seizures in rats

European Journal of Pharmacology, 1990
The ability of MK-801, an N-methyl-D-aspartate (NMDA)-channel antagonist, to suppress alcohol withdrawal seizures generated audio-genically was studied in adult male rats using a cross-over experimental design. MK-801 treatment reduced overall seizure score and proportion of rats seizing.
Richard A Morrisett
exaly   +3 more sources

Characteristics of MK-801-induced locomotor sensitization

Biochemical and Biophysical Research Communications, 2023
Repeated administration of drugs of abuse leads to progressively greater behavioral responses; this phenomenon is referred to as behavioral sensitization. MK-801 blocks the N-methyl-d-aspartate (NMDA) receptor and elicits behavioral sensitization. Ketamine and phencyclidine, are also NMDA antagonists and have well-documented abuse potential. This study
Gang Li, Shijie Xu, Ung Gu Kang
openaire   +2 more sources

Lidocaine, MK-801, and MAC

Anesthesia & Analgesia, 2007
Previous studies have found that the local anesthetic/sodium channel blocker lidocaine decreased MAC by maximum amounts approximately equal to the decreases produced by dizocilpine (MK-801), a N-methyl-d-aspartate (NMDA) receptor antagonist. Blockade of sodium channels by inhaled anesthetics has been suggested as a possible cause for impairment of ...
Yi, Zhang, Michael J, Laster, Edmond I, Eger, Manohar, Sharma, James M, Sonner   +4 more
openaire   +2 more sources

MK-801-induced and scopolamine-induced hyperactivity in rats neonatally treated chronically with MK-801

Behavioural Pharmacology, 2013
This study investigated the effects of chronic neonatal blockade of N-methyl-D-aspartate (NMDA) receptors on NMDA and muscarinic acetylcholine receptor-mediated neurotransmission in adulthood. Rats neonatally treated chronically with MK-801/saline were tested for 40 min, at the age of 14-16 weeks, for locomotor activity in an open field immediately ...
Hiroki, Furuie, Kazuo, Yamada, Yukio, Ichitani   +2 more
openaire   +2 more sources

[3H]MK-801 binding in Alzheimer's disease

Neuroscience Letters, 1988
The density of [3H]MK-801 binding sites was studied in homogenates prepared from different cortical regions of postmortem brains of Alzheimer patients and age matched controls. Highest number of binding sites for this noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor was in temporal pole (Brodmann area A-38) in both groups.
M M, Mouradian, P C, Contreras, J B, Monahan, T N, Chase   +3 more
openaire   +2 more sources

MK-801-induced neuronal damage in rats

Brain Research, 1997
The non-competitive N-methyl-D-aspartate antagonist MK-801 has been frequently used to attenuate neurotoxicity mediated by excessive release of glutamate. However, doses of MK-801, effective to prevent cell loss in some areas have been reported to induce pathological changes in retrosplenial cortex [32].
Z C, Horváth, J, Czopf, G, Buzsáki
openaire   +2 more sources

Bupivacaine-Induced Convulsion is Suppressed by MK-801

Regional Anesthesia & Pain Medicine, 1998
Background and Objectives Not only the facilitation of inhibitory synapses but also the suppression of excitatory synapses may be effective in treating convulsion induced by local anesthetics. The effects of MK-801, a N-methyl-D-aspartate (NMDA) receptor antagonist, on bupivacaine-induced convulsion and hemodynamic ...
T, Kasaba, S, Shiraishi, M, Taniguchi, M, Takasaki   +3 more
openaire   +2 more sources

Ameliorative Effect of MK-801 on Retinal Ischemia

Journal of Ocular Pharmacology and Therapeutics, 1997
The efficacy of MK-801, an N-methyl-D-aspartate receptor antagonist, was evaluated in a rat model of retinal ischemia induced by elevated intraocular pressure. Intraperitoneal injection of MK-801 at 0, 1, 3 and 10 mg/kg was given immediately after reperfusion.
T T, Lam, E, Siew, R, Chu, M O, Tso
openaire   +2 more sources