Results 171 to 180 of about 16,176 (222)

Acute behavioral effects of MK-801 in the mouse

Pharmacology Biochemistry and Behavior, 1996
The acute effects of 0.05 mg/kg MK-801 on spatial learning and memory in male mice were studied using a modified hole board food search task. Dose-response sensorimotor and activity tests suggested that this dose of MK-801 did not induce significant nonassociative effects.
G, Brosnan-Watters, D F, Wozniak, A, Nardi, J W, Olney   +3 more
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Ameliorative Effect of MK-801 on Retinal Ischemia

Journal of Ocular Pharmacology and Therapeutics, 1997
The efficacy of MK-801, an N-methyl-D-aspartate receptor antagonist, was evaluated in a rat model of retinal ischemia induced by elevated intraocular pressure. Intraperitoneal injection of MK-801 at 0, 1, 3 and 10 mg/kg was given immediately after reperfusion.
T T, Lam, E, Siew, R, Chu, M O, Tso
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The discriminative stimulus effects of MK-801 in pigeons

Behavioural Pharmacology, 1991
The discriminative stimulus effects of MK-801 [(+)-5-methyl-10, 11-dihydroxy-5H-dibenzo (a,d) cyclohepten-5, 10-imine], a proposed noncompetitive N-methyl-D-aspartate (NMDA) antagonist, were studied in pigeons discriminating MK-801 from saline, responding being maintained by food.
E.R., Butelman, C.P., France, J.H., Woods   +2 more
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MK-801-induced neuronal damage in rats

Brain Research, 1997
The non-competitive N-methyl-D-aspartate antagonist MK-801 has been frequently used to attenuate neurotoxicity mediated by excessive release of glutamate. However, doses of MK-801, effective to prevent cell loss in some areas have been reported to induce pathological changes in retrosplenial cortex [32].
Z C, Horváth, J, Czopf, G, Buzsáki
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In Vitro Cerebral Vasoactive Effects of MK-801

Journal of Neurosurgical Anesthesiology, 1995
MK-801, although more consistently neuroprotective in focal ischemia, has had more variable success in the management of global ischemia. This difference could be due to a vasoactive effect that would improve blood flow in focal ischemia but would not be operative in global ischemia.
A W, Gelb, C, Zhang, J T, Hamilton
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Influence of MK-801 on the anticonvulsant activity of antiepileptics

European Journal of Pharmacology, 1991
MK-801 (a potent non-competitive antagonist of N-methyl-D-aspartic acid-mediated events) in subcutaneous doses of 0.1 and 0.2 mg/kg increased the threshold for electroconvulsions and in doses of 0.0031 and 0.0125 mg/kg enhanced the protective activity of valproate against maximal electroshock-induced convulsions in mice. Valproate-induced side-effects (
E, Urbańska, M, Dziki, Z, Kleinrok, S J, Czuczwar, W A, Turski   +4 more
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A Radioimmunoassay for the Anticonvulsant and Neuroprotective Agent, MK-801%

Journal of Immunoassay, 1990
A radioimmunoassay is described for MK-801, a potent anticonvulsant and neuroprotective agent. Two immunogens were prepared from N-glutaryl- and N-carboxyethyl-MK-801 by coupling through their carboxyl groups to bovine serum albumin. Radioligands were I-125-iodotyramine conjugates of the same derivatives.
M, Hichens, T F, Greber, K P, Vyas
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The topography of MK-801-induced locomotor patterns in rats

Physiology & Behavior, 1989
Locomotor patterns in rats given systemic injections of the novel, noncompetitive N-methyl-D-aspartate (NMDA) antagonist, MK-801 were characterized using Digiscan Animal Activity Monitoring System. At low systemic doses, MK-801 produced an activity pattern most similar to patterns previously described for less potent noncompetitive NMDA antagonists ...
L M, Ford, A B, Norman, P R, Sanberg
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Effect of (+)MK-801 and ketamine on rapid tolerance to ethanol

Brain Research Bulletin, 1992
The motor impairment (tilt-plane test) responses to ethanol were significantly reduced on days 2, 3, 4, or 5 in rats receiving ethanol (2.3 and 1.7 g/kg) 24 and 22 h earlier, compared to the control group pretreated with saline. Administration of (+)MK-801, prior to behavioral testing with ethanol on day 1, inhibited the development of tolerance on all
J M, Khanna, H, Kalant, G, Shah, A, Chau
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Effect of Riluzole on MK-801 and Amphetamine-Induced Hyperlocomotion

Neuropsychobiology, 2003
N-methyl-<i>D</i> aspartate (NMDA) antagonists, such as MK-801, and the dopamine indirect agonist amphetamine are pharmacological models used for the evaluation of putative new treatments for schizophrenia. Since the psychotomimetic effects of NMDA antagonists have recently been linked to their ability to increase glutamate release and ...
Adriana, Lourenço Da Silva, Anselmo, Hoffmann, Marcelo O, Dietrich, Oscar P, Dall'Igna, Diogo O, Souza, Diogo R, Lara   +5 more
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