Results 171 to 180 of about 24,407 (221)
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Behavioral effects of MK-801 in the rat
Psychopharmacology, 1990Several experiments were conducted to study the effects of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801, on learning and memory in the rat. Rats displayed impaired performance on several sensorimotor tests and appeared grossly intoxicated when treated IP with 0.2 mg/kg MK-801, but not when treated with lower doses (0.05 or
D F, Wozniak +4 more
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In Vitro Cerebral Vasoactive Effects of MK-801
Journal of Neurosurgical Anesthesiology, 1995MK-801, although more consistently neuroprotective in focal ischemia, has had more variable success in the management of global ischemia. This difference could be due to a vasoactive effect that would improve blood flow in focal ischemia but would not be operative in global ischemia.
A W, Gelb, C, Zhang, J T, Hamilton
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Neuroprotection by MK-801 in temperature maintained gerbils
Brain Research Bulletin, 1995Hypothermia reduces ischemic brain damage, confounding interpretation of the neuroprotective effects of drugs. Specifically, the neuroprotectant MK-801 has been shown to cause hypothermia. Some have claimed that when body temperature is maintained, MK-801 is not a neuroprotectant, whereas others claim it retains its neuroprotective activity. MK-801 was
C A, Hoffman, C A, Boast
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Amnesic effect of the novel anticonvulsant MK-801
Pharmacology Biochemistry and Behavior, 1988MK-801, a reported N-methyl-D-aspartate (NMDA) antagonist with affinity for the phencyclidine (PCP) receptor, injected intravenously in mice before a training trial in a passive avoidance procedure, produced a similar amnesic effect to that produced by the standard amnesic agent scopolamine.
M J, Benvenga, T C, Spaulding
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Paradoxical effects of very low dose MK-801
European Journal of Pharmacology, 2006Systemic injection of the noncompetitive NMDA (N-methyl-D-aspartate) receptor antagonist MK-801 (dizocilpine maleate) is known to cause increased locomotion and various stereotypic behaviors in rodents. However, the MK-801 dose ranges commonly examined usually begin at tenth of mg/kg and going higher, with the implicit assumption of lower doses being ...
Yuanjia, Tang +7 more
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MK‐801 inhibition of nicotinic acetylcholine receptor channels
Synapse, 1991AbstractMK‐801 is a potent inhibitor of the NMDA subtype of glutamate receptors. Single‐channel and macroscopic current indicate that MK‐801 also inhibits nicotinic acetylcholine receptors (nAChRs). MK‐801 does not significantly increase desensitization of the nAChR, the main action of MK‐801 is to enter and block the open channel.
M, Amador, J A, Dani
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MK-801 and NBQX prevent electrically induced status epilepticus
NeuroReport, 1994MUSCARINIC, NMDA and metabotropic glutamate receptor antagonists were tested for anticonvulsant effects in a continuous hippocampal stimulation model in rats in order to identify the receptors involved in the initiation of electrically induced status epilepticus (SE).
D, Young, M, Dragunow
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MK-801 decreases striatal and cortical GAD65 mRNA levels
NeuroReport, 1995Levels of mRNAs encoding for the two isoforms of glutamate decarboxylase, GAD67 and GAD65, were quantified in the rat striatum and cerebral cortex following single injections of the non-competitive NMDA receptor antagonist MK-801. Acute MK-801 induced a dose-dependent decrease in GAD65 mRNA levels in ventral sectors of the dorsal striatum.
N, Laprade, J J, Soghomonian
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Enhanced MK-801-induced locomotion in Kir6.2 knockout mice
Neuroscience Research, 2012ATP-sensitive K(+) (K-ATP) channels provide a unique link between cellular energetics and electrical excitability, and also act as a unifying molecular coordinator of the body's response to stress. Although the body's response to stress is implicated in the worsening or relapse of psychotic symptoms in schizophrenia, the role of K-ATP channels remains ...
Yan, Zhou +5 more
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MK-801 Limits Neurovascular Dysfunction during Experimental Allergic Encephalomyelitis
The Journal of Pharmacology and Experimental Therapeutics, 1997Increased permeability of the blood-brain barrier (BBB) is a characteristic of the demyelinating disease multiple sclerosis and the animal counterpart experimental allergic encephalomyelitis (EAE). In physically traumatized cerebral tissue neurovascular damage, linked with activation of the cerebroendothelial-bound N-methyl-D-aspartate receptor, can be
C, Bolton, C, Paul
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