Results 191 to 200 of about 16,176 (222)
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Inhibition of autoradiographic MK-801 binding by an endogenous factor
Neuroscience Letters, 1994In an autoradiographic assay of glutamate/glycine-stimulated [3H]MK-801-binding, a 30-min prewash of tissue sections in buffer resulted in a 40-78% enhancement of binding over that in the absence of a prewash. Inclusion of buffer used for the prewash in the binding assay significantly inhibited binding in prewashed sections.
R H, Porter, J T, Greenamyre
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Evaluation of brain pharmacokinetics of (+)MK-801 in relation to behaviour
Neuroscience Letters, 2011The non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist (+)MK-801 is widely used in animal research (over 3000 publications), however its extracellular brain concentration has never been reported. Here, we show using in vivo microdialysis that systemic injection of (+)MK-801 at doses of 0.05, 0.1 or 0.2mg/kg resulted in peak brain ECF ...
Nico, Wegener +7 more
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Anticonvulsant effects of diazepam and MK-801 in soman poisoning
Epilepsy Research, 1990An animal model was developed to evaluate the anticonvulsant effects of diazepam and MK-801 in soman poisoning and to examine the possible mechanism of soman-induced convulsions. The oxime HI-6 (125 mg/kg, i.p.) was given to male rats, to increase survival, 30 min prior to 180 micrograms/kg, s.c. (equivalent to 1.6 x LD50) of soman, which produced 100%
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Topiramate antagonizes MK-801 in an animal model of schizophrenia
European Journal of Pharmacology, 2002The phencyclidine (PCP) model of schizophrenia suggests that N-methyl-D-aspartate (NMDA) receptor hypofunction and its consequences may play an important role in the pathophysiology of this psychiatric disorder. Moreover, the schizophreniform psychosis caused by PCP resembles schizophrenia in all of the relevant domains of psychopathology, especially ...
Stephen I, Deutsch +4 more
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Comparative neurobiological effects of ibogaine and MK-801 in rats
Drug and Alcohol Dependence, 2000Ibogaine is a plant-derived alkaloid with putative 'anti-addictive' properties. Although ibogaine binds to multiple targets in the brain, recent evidence suggests the drug acts as an N-methyl-D-aspartate (NMDA) antagonist similar to MK-801. The purpose of the present study was to compare neurochemical and neuroendocrine effects of ibogaine and MK-801 ...
M H, Baumann, R B, Rothman, S F, Ali
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Dizocilpine (MK-801) in Cerebral Ischemia
1992Dizocilpine maleate (MK-801) is a drug with potential use in cerebral ischemia. However, controversy concerns its effectiveness in various ischemic settings, and the acceptability of side effects and potential toxicity. This article will review data from our laboratory and from the literature, amalgamating the existing evidence and pointing to ...
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MK‐801 inhibition of nicotinic acetylcholine receptor channels
Synapse, 1991AbstractMK‐801 is a potent inhibitor of the NMDA subtype of glutamate receptors. Single‐channel and macroscopic current indicate that MK‐801 also inhibits nicotinic acetylcholine receptors (nAChRs). MK‐801 does not significantly increase desensitization of the nAChR, the main action of MK‐801 is to enter and block the open channel.
M, Amador, J A, Dani
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MK-801 Treatment of Oligodendrocytes as a Cellular Model of Aging
2020Cardiovascular-related accidents such as stroke are currently ranked as the second leading cause of death worldwide, and the risk of stroke increases dramatically with age. Aging results in structural and functional alterations of the oligodendrocytes which lead to loss of neuronal connectivity, cognitive deficits, and increased susceptibility to ...
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Chronic neonatal MK-801 treatment increases MK-801-induced hyperlocomotion in adulthood
Neuroscience Research, 2011Hiroki Furuie +3 more
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