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MK-801 induces a low intensity conditioned taste aversion
Pharmacology Biochemistry and Behavior, 2012N-methyl-D-aspartate (NMDA) receptor antagonists are often used to assess the role of NMDA receptors in learning and memory processes. However, few studies have explored the possibility that the antagonists may induce a conditioned aversion when administered following flavor consumption.
Luis M, Traverso +2 more
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MK-801 powerfully protects against N-methyl aspartate neurotoxicity
European Journal of Pharmacology, 1987Using the ex vivo chick embryo retina to study the efficacy of antagonists in blocking the excitotoxic effects of excitatory amino acid agonists, we previously identified phencyclidine as the most powerful known anti-excitotoxin. Here we show that MK-801 is 5 times more powerful than phencyclidine as an anti-excitotoxin, that its antagonism is specific
J, Olney +4 more
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MK-801-induced dystonia in cebus monkeys.
Clinical neuropharmacology, 1999MK-801 (dizocilpine), a noncompetitive N-methyl-D-aspartate antagonist, induces dystonia in monkeys at doses of 0.08 mg/kg. This syndrome was tested with the dopamine D1 receptor antagonist NNC 756, the DA D2 receptor antagonist raclopride, the atypical antipsychotic clozapine, the dopamine D1 receptor agonist SKF 81297, the dopamine D2/D3 receptor ...
M, Madsen, H, Lublin
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Chronic neonatal MK-801 treatment increases MK-801-induced hyperlocomotion in adulthood
Neuroscience Research, 2011Hiroki Furuie +3 more
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Possible abuse potential of the NMDA antagonist MK-801
Behavioural Brain Research, 1989Selective antagonists of the N-methyl-D-aspartate (NMDA) receptor such as MK-801 may have therapeutic potential in the treatment of ischemic brain injury. However, some drugs (e.g. ketamine and phencyclidine) with potent NMDA antagonist properties are also addictive.
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Neurocytotoxicity of phencyclidine and MK-801
Biological Psychiatry, 1989John W. Olney +2 more
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MK-801 subsensitivity following postweaning lead exposure.
Neurotoxicology, 1995This study sought to determine whether the reported lead-induced inhibition of binding of the non-competitive NMDA receptor complex antagonist, MK-801, was of sufficient biological strength and relevance to produce changes in MK-801 behavioral sensitivity.
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MK 801: A Possible Neuroprotective Agent by Poststroke Depression?
Journal of Neuropsychiatry, 2008Ozan, Erol, Yulug, Burak, Cam, Ertugrul
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