Results 181 to 190 of about 16,176 (222)
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Valproate prevents the induction and the expression of MK-801 sensitization
Brain Research, 2002Repeated administration of psychostimulants such as amphetamine, cocaine, and methylphenidate has been shown to induce behavioral sensitization. Sodium valproate, an anticonvulsant agent that enhances GABA activity, and dizocilpine (MK-801), a non-competitive NMDA receptor antagonist, can block the sensitization elicited by psychostimulants.
Pamela B, Yang +2 more
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Kainate-induced functional deficits are not blocked by MK-801
Neuroscience Letters, 1990Male, Fischer-344 rats were pretreated with MK-801 (0.1, 1.0 or 10.0 mg/kg, i.p.) prior to bilateral injection of kainate (0.33 micrograms/site) into the dorsal and ventral hippocampus. Kainate impaired the acquisition of a water maze acquisition task 4 weeks after surgery, an effect not attenuated by pretreatment with MK-801.
B C, Rogers, H A, Tilson
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Paradoxical effects of very low dose MK-801
European Journal of Pharmacology, 2006Systemic injection of the noncompetitive NMDA (N-methyl-D-aspartate) receptor antagonist MK-801 (dizocilpine maleate) is known to cause increased locomotion and various stereotypic behaviors in rodents. However, the MK-801 dose ranges commonly examined usually begin at tenth of mg/kg and going higher, with the implicit assumption of lower doses being ...
Yuanjia, Tang +7 more
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Modulation of MK-801 response by dopaminergic agents in mice
Psychopharmacology, 1992Various doses of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, MK-801 (0.1-0.5 mg/kg) and ketamine (2.5-10 mg/kg), produced a dose-dependent increase in stereotypic behaviour in naive mice. MK-801 (0.1 mg/kg) and ketamine (2.5 mg/kg) potentiated the stereotypic response of apomorphine (0.1-0.5 mg/kg) in mice pretreated with ...
A, Verma, S K, Kulkarni
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Effect of MK‐801 on gene expressions in the amygdala of rats
Synapse, 2007AbstractRodents treated with N‐methyl‐D‐aspartate (NMDA) antagonists have been thought to be an animal model of schizophrenia. In this study, we examined gene expression in the amygdala of rats chronically treated with MK‐801, as well as behavioral changes, such as social behavior, in these animals.
Tadasu, Matsuoka +10 more
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Tolerance to and dependence on MK-801 (dizocilpine) in rats
Pharmacology Biochemistry and Behavior, 1994Rats were trained to respond under a fixed-ratio 30 schedule for food presentation during four daily 0.5-h sessions occurring every 6 h. After stable baseline response was established, osmotic minipumps were implanted that infused vehicle or (+)-5 methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine hydrogen maleate (dizocilpine; MK-801), SC ...
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Sex differences in dizocilpine (MK-801) neurotoxicity in rats
Environmental Toxicology and Pharmacology, 1999The sex differences in the clinical signs and the distribution of astrocytic glial fibrillary acidic protein (GFAP) induced by an N-methyl-d-aspartate antagonist, dizocilpine (MK-801), were examined. A single intraperitoneal injection of MK-801 (5 mg/kg body weight) caused a prolonged recumbency (35-40 h), leading to a severe loss of body weight in ...
G H, Hur +4 more
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MK-801 Interferes with Nutrient-related Signals for Satiation
Appetite, 1998Abstract We previously reported that MK-801, a non-competitive N -methyl- d -aspartate (NMDA) receptor antagonist, increased food intake by rats. Increased intake occurred only when deprivation or presentation of a highly preferred food had initiated feeding. MK-801 did not cause initiation of food intake.
G A, Burns +2 more
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Anticonvulsant effects of MK-801 and glycine on hippocampal afterdischarge
Experimental Neurology, 1989The effects of glycine and MK-801 on hippocampal seizure threshold and afterdischarge (AD) were determined in freely moving rats implanted with intracranial electrodes. The 0.25 mg/kg (ip) dose of MK-801 significantly reduced the primary hippocampal and cortical AD but induced neurological deficit in 4 of 16 rats.
S L, Peterson, L E, Boehnke
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Effects of TCP on Spatial Memory: Comparison with MK-801
Pharmacology Biochemistry and Behavior, 1995TCP (N-[1-(2-thienyl)cyclohexyl]piperidine), A PCP (phencyclidine) derivative, has been shown to possess antiepileptic and neuroprotective efficacy against chemically induced seizures. However, it is known that other antagonists of the NMDA receptor impair spatial learning. This study was thus undertaken to explore the eventual effects of TCP on memory.
P, Filliat, G, Blanchet
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