Results 181 to 190 of about 24,407 (221)
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MK-801 Protects against Carbon Monoxide-Induced Hearing Loss
Toxicology and Applied Pharmacology, 1995MK-801, a glutamate receptor blocker, has been reported to protect against hypoxic-ischemic neuronal degeneration. The purpose of this study was to investigate the protective effects of MK-801 on cochlear impairment induced by carbon monoxide (CO) in the guinea pig and whether the protection reflected systemic or local effects.
Y, Liu, L D, Fechter
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The discriminative stimulus effects of MK-801 in pigeons
Behavioural Pharmacology, 1991The discriminative stimulus effects of MK-801 [(+)-5-methyl-10, 11-dihydroxy-5H-dibenzo (a,d) cyclohepten-5, 10-imine], a proposed noncompetitive N-methyl-D-aspartate (NMDA) antagonist, were studied in pigeons discriminating MK-801 from saline, responding being maintained by food.
E.R., Butelman +2 more
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MK-801 Interferes with Nutrient-related Signals for Satiation
Appetite, 1998Abstract We previously reported that MK-801, a non-competitive N -methyl- d -aspartate (NMDA) receptor antagonist, increased food intake by rats. Increased intake occurred only when deprivation or presentation of a highly preferred food had initiated feeding. MK-801 did not cause initiation of food intake.
G A, Burns +2 more
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Acute behavioral effects of MK-801 in the mouse
Pharmacology Biochemistry and Behavior, 1996The acute effects of 0.05 mg/kg MK-801 on spatial learning and memory in male mice were studied using a modified hole board food search task. Dose-response sensorimotor and activity tests suggested that this dose of MK-801 did not induce significant nonassociative effects.
G, Brosnan-Watters +3 more
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Dizocilpine (MK-801) in Cerebral Ischemia
1992Dizocilpine maleate (MK-801) is a drug with potential use in cerebral ischemia. However, controversy concerns its effectiveness in various ischemic settings, and the acceptability of side effects and potential toxicity. This article will review data from our laboratory and from the literature, amalgamating the existing evidence and pointing to ...
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MK-801 enhances noradrenergic neurotransmission in rat vas deferens
European Journal of Pharmacology, 1996The effect of MK-801 (dizocilpine) on the noradrenergic neurotransmission of the epididymal portion of rat vas deferens has been investigated. This drug potentiated the electrically induced responses (46.6% +/- 5.09 at a concentration of 3.7 microM) and the contractile effect of exogenous noradrenaline with a concentration-dependent reduction of EC50 ...
D, Pubill +5 more
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Sex differences in dizocilpine (MK-801) neurotoxicity in rats
Environmental Toxicology and Pharmacology, 1999The sex differences in the clinical signs and the distribution of astrocytic glial fibrillary acidic protein (GFAP) induced by an N-methyl-d-aspartate antagonist, dizocilpine (MK-801), were examined. A single intraperitoneal injection of MK-801 (5 mg/kg body weight) caused a prolonged recumbency (35-40 h), leading to a severe loss of body weight in ...
G H, Hur +4 more
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[3H]MK-801 binding sites in neonate rat brain
Brain Research, 1989[3H]MK-801 binding sites are present in neonate rat brain as early as 3 days after birth. Immature hippocampus and cortex contain approximately one sixth the concentration of binding sites of the adult, while brainstem concentration is twice as high as that of adult. [3H]MK-801 binding is stimulated by glutamate and glycine and blocked by phencyclidine
A M, Morin +3 more
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MK-801 reduced cerebral ischemic injury by inducing hypothermia
Brain Research, 1990The non-competitive N-methyl-D-aspartate (NMDA) antagonist, MK-801, has been reported to prevent or attenuate ischemic brain damage in various animal models. In halothane-anesthetized gerbils it was found that an optimal dose of MK-801 (3.0 mg/kg) for providing cerebral protection also produced hypothermia (31.1 +/- 0.62 degrees C) relative to control ...
D, Corbett +4 more
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Postnatal lead exposure and MK-801 sensitivity.
Neurotoxicology, 1997Postweaning Pb exposure has been associated with subsensitivity to the stimulus properties of the non-competitive NMDA receptor complex antagonist MK-801 (Cory-Slechta, 1995a). This study sought to determine whether Pb exposures occurring postnatally, i.e., during the primary period of development of many NMDA receptor subunits, would alter the nature ...
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