Results 1 to 10 of about 46,202 (182)

Mlh2 is an accessory factor for DNA mismatch repair in Saccharomyces cerevisiae. [PDF]

PLoS Genetics, 2014
In Saccharomyces cerevisiae, the essential mismatch repair (MMR) endonuclease Mlh1-Pms1 forms foci promoted by Msh2-Msh6 or Msh2-Msh3 in response to mispaired bases. Here we analyzed the Mlh1-Mlh2 complex, whose role in MMR has been unclear.
Christopher S Campbell, Hans Hombauer, Anjana Srivatsan, Nikki Bowen, Kerstin Gries, Arshad Desai, Christopher D Putnam, Richard D Kolodner   +7 more
doaj   +5 more sources

MutLα heterodimers modify the molecular phenotype of Friedreich ataxia. [PDF]

PLoS ONE, 2014
Friedreich ataxia (FRDA), the most common autosomal recessive ataxia disorder, is caused by a dynamic GAA repeat expansion mutation within intron 1 of FXN gene, resulting in down-regulation of frataxin expression.
Vahid Ezzatizadeh, Chiranjeevi Sandi, Madhavi Sandi, Sara Anjomani-Virmouni, Sahar Al-Mahdawi, Mark A Pook   +5 more
doaj   +17 more sources

Targeting mitochondrial DNA polymerase gamma for selective inhibition of MLH1 deficient colon cancer growth.

PLoS ONE, 2022
Synthetic lethality in DNA repair pathways is an important strategy for the selective treatment of cancer cells without harming healthy cells and developing cancer-specific drugs. The synthetic lethal interaction between the mismatch repair (MMR) protein,
Berna Somuncu, Aysegul Ekmekcioglu, Fatma Merve Antmen, Tugce Ertuzun, Emre Deniz, Nazli Keskin, Joon Park, Ilgu Ece Yazici, Busra Simsek, Batu Erman, Whitney Yin, Burak Erman, Meltem Muftuoglu   +12 more
doaj   +4 more sources

Epigenetic Silencing of the MLH1 Promoter in Relation to the Development of Gastric Cancer and its use as a Biomarker for Patients with Microsatellite Instability: a Systematic Analysis

Cellular Physiology and Biochemistry, 2018
Background/Aims: Human mutL homolog 1 (MLH1) promoter methylation was reported in gastric cancer (GC). This study determined the clinicopathological, prognostic, and diagnostic effects of MLH1 promoter methylation in GC. Methods: The combined odds ratio (
Guimei Hu, Lijun Qin, Xinjun Zhang, Guoliang Ye, Tao Huang   +4 more
doaj   +2 more sources

Integrative proteomics reveals mitochondrial and immune signatures of MLH1 exon 13 deletion in Lynch syndrome–associated colorectal cancer [PDF]

Frontiers in Molecular Biosciences
BackgroundLynch syndrome is an inherited cancer predisposition caused by pathogenic variants in mismatch repair (MMR) genes. Large genomic rearrangements (LGRs) in MLH1 are often underestimated due to detection challenges. Functional analyses of specific
Chen Chang, Yue Cao, Bin Zhang, Jingli Chen, Lin Chen, Wensheng Li, Guorong Wang   +6 more
doaj   +2 more sources

Aberrant cytoplasmic localization of MLH1 characterizes a cell population that seeds breast cancer recurrence [PDF]

Nature Communications
Estrogen receptor-positive breast cancer remains a leading cause of cancer-related death in women, with mortality largely driven by late recurrence of treatment-resistant disease.
Aloran Mazumder, Jerry Dewitt, Elena Oropeza, Nindo Punturi, Daniel Lozano, Megha Raghunathan, Jonathan Piscitelli, Elham Sajjadi, Elena GueriniRocco, Konstantinos Venetis, Mariia Ivanova, Eltjona Mane, Marianna Dercole, Alberto Concardi, Nicola Fusco, Carol Manhart, Matthew Bainbridge, Svasti Haricharan   +17 more
doaj   +2 more sources

Expression and prognostic significance of MLH1 and GPRC5C in resectable hepatocellular carcinoma [PDF]

BMC Cancer
Background It has recently been shown that mut-L homolog 1 (MLH1), frequently lost in cancer initiation and progression, inhibited pancreatic cancer metastatic potential by downregulating G-protein coupled receptor C5C (GPRC5C). However, their expression
Jun Lu, Lei Li, Qing Chen, Bingqi Li, Siqian Ren, Meng Yuan, Meng Meng, Jian Lei, Yuntao Bing, Hangyan Wang, Zhaolai Ma, Dianrong Xiu, Chunhui Yuan   +12 more
doaj   +2 more sources

Hesperetin effect on MLH1 and MSH2 expression on breast cancer cells BT-549

Journal of Advanced Pharmaceutical Technology & Research, 2023
Due to its genetic and phenotypic heterogeneity, breast cancer is very difficult to eliminate. The harmful consequences of conventional therapies like radiation and chemotherapy have prompted the search for organic-based alternatives. Hesperetin (HSP), a
Assim Khattab Hasan, Esmaeil Babaei, Ahmed Salim Kadhim Al-Khafaji   +2 more
doaj   +1 more source

Hereditary ovarian cancer

Сибирский онкологический журнал, 2022
Background. Hereditary genetic mutations are a significant risk factor for malignant transformation of cells and cancer development. Hereditary genetic mutations account for 15 to 25 % of all ovarian carcinomas. Purpose of the study: to summarize data on
Kh. B. Kotiv, T. V. Gorodnova, A. P. Sokolenko, I. V. Berlev, E. N. Imyanitov   +4 more
doaj   +1 more source

MLH1 mediates cytoprotective nucleophagy to resist 5-Fluorouracil-induced cell death in colorectal carcinoma

Neoplasia: An International Journal for Oncology Research, 2022
Colorectal Cancer (CRC) with Microsatellite instability (MSI) and mutLhomolog-1 (MLH1) gene deficiency are less aggressive than MLH1 proficient cancers.
Shaista Manzoor, Maha Saber-Ayad, Azzam A. Maghazachi, Qutayba Hamid, Jibran Sualeh Muhammad   +4 more
doaj   +1 more source