Results 11 to 20 of about 46,287 (264)

Selection of patients with germline MLH1 mutated Lynch syndrome by determination of MLH1 methylation and BRAF mutation [PDF]

Familial Cancer, 2018
Lynch syndrome is one of the most common hereditary colorectal cancer (CRC) syndrome and is caused by germline mutations of MLH1, MSH2 and more rarely MSH6, PMS2, MLH3 genes.
Benhattar, Jean, Bouzourene, Hanifa, Hutter, Pierre, Losi, Lorena, Martin, Patricia   +4 more
core   +5 more sources

MLH1 Gene Promoter Hypermethylation Negative [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources

Relationship between the expression of mismatch repair proteins and colorectal cancer with mesenteric tumor deposit

Zhongguo linchuang yanjiu, 2023
Objective To investigate the clinicopathological significance of colorectal cancer with mesenteric tumor deposit(TD) and the relationship with DNA mismatch repair(MMR) protein expression.
HUANG Ke-qiang, TANG Hua, HUANG Qiu-xia, OU Hai-ling
doaj   +1 more source

Identifying primary and secondary MLH1 epimutation carriers displaying low-level constitutional MLH1 methylation using droplet digital PCR and genome-wide DNA methylation profiling of colorectal cancers

Clinical Epigenetics, 2023
Background MLH1 epimutation is characterised by constitutional monoallelic MLH1 promoter hypermethylation, which can cause colorectal cancer (CRC). Tumour molecular profiles of MLH1 epimutation CRCs were used to classify germline MLH1 promoter variants ...
Jihoon E. Joo, Khalid Mahmood, Romy Walker, Peter Georgeson, Ida Candiloro, Mark Clendenning, Julia Como, Sharelle Joseland, Susan Preston, Lise Graversen, Mathilda Wilding, Michael Field, Michelle Lemon, Janette Wakeling, Helen Marfan, Rachel Susman, Joanne Isbister, Emma Edwards, Michelle Bowman, Judy Kirk, Emilia Ip, Lynne McKay, Yoland Antill, John L. Hopper, Alex Boussioutas, Finlay A. Macrae, Alexander Dobrovic, Mark A. Jenkins, Christophe Rosty, Ingrid M. Winship, Daniel D. Buchanan   +30 more
doaj   +1 more source

Isolated MLH1 Loss by Immunohistochemistry Because of Benign Germline MLH1 Polymorphisms

JCO Precision Oncology, 2022
PURPOSE Mismatch repair (MMR) immunohistochemistry (IHC) is frequently used to inform prognosis, select (immuno-)therapy, and identify patients for heritable cancer syndrome testing. However, false-negative and false-positive MMR IHC interpretations have been described.
Dustin E. Bosch, Matthew M. Yeh, Stephen J. Salipante, Angela Jacobson, Stacey A. Cohen, Eric Q. Konnick, Vera A. Paulson   +6 more
openaire   +2 more sources

Two distinct deleterious causative variants in a family with multiple cancer-affected patients

Advanced Biomedical Research, 2023
Background: Only 5 to 10% of cancers are hereditary, but they are particularly important since they can be passed down from generation to generation, and family members are at elevated risk.
Erfan Khorram, Mohammad A Tabatabaiefar, Mehrdad Zeinalian   +2 more
doaj   +1 more source

Negative heterosis for meiotic recombination rate in spermatocytes of the domestic chicken Gallus gallus

Вавиловский журнал генетики и селекции, 2021
Benefits and costs of meiotic recombination are a matter of discussion. Because recombination breaks allele combinations already tested by natural selection and generates new ones of unpredictable fitness, a high recombination rate is generally ...
L. P. Malinovskaya, K. V. Tishakova, T. I. Bikchurina, A. Yu. Slobodchikova, N. Yu. Torgunakov, A. A. Torgasheva, Y. A. Tsepilov, N. A. Volkova, P. M. Borodin   +8 more
doaj   +1 more source

MSH2 and MLH1 testing [PDF]

Hereditary Cancer in Clinical Practice, 2008
DNA testing is recommended in families fulfilling at least "suspected HNPCC" criteria. After exclusion of FAP (characteristic FAP features include polyposis, congenital hypertrophy of the retinal pigment epithelium, cysts and osteomata of bones of the maxilla and mandible, desmoid tumours), immunohistochemical analyses (IHC) of MLH1, MSH2 and MSH6 ...
Kurzawski Grzegorz, Suchy Janina, Lubiński Jan   +2 more
openaire   +3 more sources

Hepatica transsilvanica Fuss (Ranunculaceae) is an Allotetraploid Relict of the Tertiary Flora in Europe – Molecular Phylogenetic Evidence

Acta Societatis Botanicorum Poloniae, 2020
The Hepatica section Angulosa consists of mainly tetraploid (2n = 28) species that are distributed disjunctly throughout Eurasia. Karyological evidence proves the hybrid origin of the polyploid species of this section. Hepatica transsilvanica is a member
Levente Laczkó, Gábor Sramkó
doaj   +1 more source

CTGF and MLH1 Gene Expression Levels in Colorectal Cancer Tumor Tissues and Adjacent Normal Tissues in Patients in Golestan Province [PDF]

Journal of Mazandaran University of Medical Sciences, 2023
Background and purpose: Colorectal cancer is the third most common type of cancer in terms of incidence and the second most common cause of cancer-related death worldwide.
Amin Lotfvarzi, Farkhondeh Nemati
doaj