Results 51 to 60 of about 46,287 (264)

MLH1 Deficiency Induces Cetuximab Resistance in Colon Cancer via Her‐2/PI3K/AKT Signaling

Advanced Science, 2020
The rapid onset of resistance to cetuximab (CTX) limits its clinical utility in colorectal cancer (CRC) patients. This study aims to understand a potential role of mismatch repair gene mutL homolog 1 (MLH1) in CTX response. Functional analysis of MLH1 in
Ying Han, Yinghui Peng, Yaojie Fu, Changjing Cai, Cao Guo, Shanshan Liu, Yiyi Li, Yihong Chen, Edward Shen, Kexin Long, Xinwen Wang, Jian Yu, Hong Shen, Shan Zeng   +13 more
doaj   +1 more source

Licensing MLH1 sites for crossover during meiosis [PDF]

Nature Communications, 2014
During meiosis, homologous chromosomes synapse and recombine at sites marked by the binding of the mismatch repair protein MLH1. In hexaploid wheat, the Ph1 locus has a major effect on whether crossover occurs between homologues or between related homoeologues.
Martín Ramírez, Azahara Carmen, Shaw, Peter, Phillips, Dylan, Reader, Steve, Moore, Graham   +4 more
openaire   +3 more sources

Regulation of the MLH1–MLH3 endonuclease in meiosis [PDF]

Nature, 2020
SummaryDuring prophase of the first meiotic division, cells deliberately break their DNA. These DNA breaks are repaired by homologous recombination, which facilitates proper chromosome segregation and enables reciprocal exchange of DNA segments between homologous chromosomes, thus promoting genetic diversity in the progeny1.
Cannavo, Elda, Sanchez, Aurore, Anand, Roopesh, Ranjha, Lepakshi, Hugener, Jannik, Adam, Céline, Acharya, Ananya, Weyland, Nicolas, Aran-Guiu, Xavier, Charbonnier, Jean-Baptiste, Hoffmann, Eva R, Borde, Valérie, Matos, Joao, Cejka, Petr   +13 more
openaire   +6 more sources

Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches [PDF]

, 2014
The Huntington's disease gene (HTT) CAG repeat mutation undergoes somatic expansion that correlates with pathogenesis. Modifiers of somatic expansion may therefore provide routes for therapies targeting the underlying mutation, an approach that is likely
Cohen, Paula E., Daly, Mark J., Dragileva, Ella, Gillis, Tammy, Guide, Jolene R., Holloway, Kim, Hou, Caixia, Kirby, Andrew, Li, Guo-Min, Lloret, Alejandro, Lopez, Edith, Panigrahi, Gagan B., Pearson, Christopher E., Pinto, Ricardo Mouro, St. Claire, Jason, Wheeler, Vanessa C.   +15 more
core   +1 more source

Evaluation of MLH1 variants of unclear significance [PDF]

Genes, Chromosomes and Cancer, 2018
Abstract Inactivating mutations in the MLH1 gene cause the cancer predisposition Lynch syndrome, but for small coding genetic variants it is mostly unclear if they are inactivating or not.
Nicole Köger, Lea Paulsen, Francisco López‐Kostner, Adriana Della Valle, Carlos Alberto Vaccaro, Edenir Inêz Palmero, Karin Alvarez, Carlos Sarroca, Florencia Neffa, Pablo German Kalfayan, Maria Laura Gonzalez, Benedito Mauro Rossi, Rui Manuel Reis, Angela Brieger, Stefan Zeuzem, Inga Hinrichsen, Mev Dominguez‐Valentin, Guido Plotz   +17 more
openaire   +3 more sources

Association between colorectal cancer, the frequency of Bacteroides fragilis, and the level of mismatch repair genes expression in the biopsy samples of Iranian patients

BMC Gastroenterology
Background Deficient DNA mismatch repair (MMR) can cause microsatellite instability (MSI) and is more common in colorectal cancer (CRC) patients.
Nooshin Nazarinejad, Bahareh Hajikhani, Amir Abbas Vaezi, Farzaneh Firoozeh, Fatemeh Sameni, Somayeh Yaslianifard, Mehdi Goudarzi, Masoud Dadashi   +7 more
doaj   +1 more source

Coordinated and Independent Roles for MLH Subunits in DNA Repair

Cells, 2021
The MutL family of DNA mismatch repair proteins (MMR) acts to maintain genomic integrity in somatic and meiotic cells. In baker’s yeast, the MutL homolog (MLH) MMR proteins form three heterodimeric complexes, MLH1-PMS1, MLH1-MLH2, and MLH1-MLH3.
Gianno Pannafino, Eric Alani
doaj   +1 more source

A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers. [PDF]

, 2016
Gross chromosomal rearrangements (GCRs) play an important role in human diseases, including cancer. The identity of all Genome Instability Suppressing (GIS) genes is not currently known.
Bell, Sara N, Clotfelter, Sarah P, de Souza, Jorge ES, de Souza, Sandro J, Fonseca, André F, Kolodner, Richard D, Martinez, Sandra L, Nene, Rahul V, Putnam, Christopher D, Somach, Steven B, Srivatsan, Anjana   +10 more
core   +2 more sources

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Haploinsufficiency by minute MutL homolog 1 promoter DNA methylation may represent unique phenotypes of microsatellite instability-gastric carcinogenesis.

PLoS ONE, 2021
Promoter DNA methylation of MutL homolog 1 (MLH1) is considered to play a causative role in microsatellite instability (MSI) carcinogenesis in primary gastric cancer, and a high MSI status is associated with treatment sensitivity to human cancers ...
Hiroki Harada, Yusuke Nie, Ippeita Araki, Takafumi Soeno, Motohiro Chuman, Marie Washio, Mikiko Sakuraya, Hideki Ushiku, Masahiro Niihara, Kei Hosoda, Yusuke Kumamoto, Takeshi Naitoh, Takafumi Sangai, Naoki Hiki, Keishi Yamashita   +14 more
doaj   +1 more source