Results 201 to 210 of about 15,502 (223)

Detection of MLKL Oligomerization During Programmed Necrosis

2018
Programmed necrosis, also known as necroptosis, is a form of regulated necrotic cell death that is mediated by receptor-interacting protein kinases RIP1 (or RIPK1), RIP3 (or RIPK3), and the mixed lineage kinase domain-like protein, MLKL. Following the induction of programmed necrosis, MLKL is phosphorylated by RIP3 and oligomerizes and then the protein
Zhenyu, Cai, Zheng-Gang, Liu
openaire   +2 more sources

GW806742X can induce mouse MLKL activation by directly promoting MLKL kinase like domain dimerization

Experimental Cell Research
The dimerization of the MLKL kinase-like domain (KLD) is a crucial step for MLKL activation in necroptosis. In 2014, it was discovered that GW806742X can directly bind to the mouse MLKL KLD via surface plasmon resonance (SPR) (Kd = 9.3 μM), inhibiting TNF-induced membrane translocation of MLKL and necroptosis.
Feiyang, Yuan, Yu, Zhang, Xinxin, Zhu, Hong, Hu, Ning, Nan, Huayi, Wang   +5 more
openaire   +2 more sources

Necroptosis: MLKL Polymerization.

Journal of nature and science
Necroptosis is a subtype of regulated necrosis that occurs when caspases are inhibited or fail to activate. Stimulus of cell death receptors results in a signaling cascade that triggers caspase independent, immunogenic cell death. The core pathway relies on receptor interacting protein kinase (RIPK) 1 and 3, which interact through their receptor ...
Andrea, Johnston, Zhigao, Wang
openaire   +1 more source

MLKL Protects Pulmonary Endothelial Cells in Acute Lung Injury

American Journal of Respiratory Cell and Molecular Biology
The role of autophagy in pulmonary microvascular endothelial cells (PMVECs) is controversial in LPS-induced acute lung injury (ALI). Mixed lineage kinase domain-like pseudokinase (MLKL) has recently been reported to maintain cell survival by facilitating autophagic flux in response to starvation rather than its well-recognized role in necroptosis ...
Ying Li, Yingxiang Liu, Xueya Yao, Ling Zhu, Liqun Yang, Qionghui Zhan   +5 more
openaire   +2 more sources

MLKL promotes hepatocarcinogenesis through inhibition of AMPK-mediated autophagy

Cell Death & Differentiation
The pseudokinase mixed lineage kinase domain-like (MLKL) is an essential component of the activation of the necroptotic pathway. Emerging evidence suggests that MLKL plays a key role in liver disease. However, how MLKL contributes to hepatocarcinogenesis has not been fully elucidated.
Xianjun Yu, Mengyuan Feng, Jian Guo, Haoyu Wang, Jun Yu, Anjie Zhang, Jingyi Wu, Yamei Han, Zequn Sun, Yingying Liao, Qun Zhao   +10 more
openaire   +2 more sources

MLKL Gene

2020
openaire   +1 more source

Dissecting the RIPK3/MLKL necroptotic molecular switch

Acta Crystallographica Section A Foundations and Advances, 2023
K. Davies, Y. Meng, C. Fitzgibbon, S. Young, S. Garnish, C. Horne, C. Luo, J. Garnier, L. Liang, A. Cowan, A. Samson, G. Lessene, J. Sandow, P. Czabotar, J. Murphy   +14 more
openaire   +1 more source

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

Immunity, 2017
David Wallach
exaly  

ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences

Cell, 2017
Yi-Nan Gong, Clifford Guy, Jan Ulrich Becker   +2 more
exaly  

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

Immunity, 2013
James M Murphy, Peter E Czabotar, Joanne M Hildebrand   +2 more
exaly