Results 41 to 50 of about 246,934 (340)

Targeting intracellular MMPs efficiently inhibits tumor metastasis and angiogenesis

Theranostics, 2018
Treatment for metastatic cancer is a great challenge throughout the world. Commonly, directed inhibition of extracellular matrix metalloproteinases (MMPs) secreted by cancer cells can reduce metastasis.
Ya-Qi Lv, Xiangmei Zhao, Lida Zhu, Si-Jia Li, Qingqing Xiao, Wei He, Li-Fang Yin   +6 more
semanticscholar   +1 more source

Effects of MMP-2 activation and FSH or LH Hormone Supplementation on Embryo Development in In Vitro Fertilization of Porcine

Journal of Animal Reproduction and Biotechnology, 2018
The purpose of this study was to analyze whether FSH and LH hormone treatment directly or indirectly affect embryo development in embryonic development.
Sang Hwan Kim, Jong Taek Yoon
doaj   +1 more source

The role of inflammatory mediators and matrix metalloproteinases (MMPs) in the progression of osteoarthritis

Biomaterials and Biosystems
Highlights • Osteoarthritis (OA) traditionally known to be a disease prevalent in geriatric populations and mechanical injury is currently observed to have significant connections relevant to inflammation and free radical biology.• Pro-and anti ...
A. Mukherjee, Bodhisatwa Das
semanticscholar   +1 more source

Seesaw of matrix metalloproteinases (MMPs).

Journal of Cancer Research and Therapeutics, 2016
The family of human matrix metalloproteinases (MMPs) comprises several tightly regulated classes of proteases. These enzymes and their specific inhibitors play important roles in tumor progression and the metastatic process by facilitating extracellular ...
C. Kapoor, S. Vaidya, V. Wadhwan, Geetpriya Kaur, A. Pathak   +4 more
semanticscholar   +1 more source

Activation of GPR40 Suppresses AGE-Induced Reduction of Type II Collagen and Aggrecan in Human SW1353 Chondrocytes

Drug Design, Development and Therapy, 2020
Jiaxiang Gu,1,* Hongsheng Lin,2,* Yiyuan Zhang,1 Tao Xu,1 Tianliang Wang,1 Xiawei Xue,1 Wenzhong Zhang,1 Hongjun Liu1 1Department of Orthopaedics, Subei People’s Hospital Affiliated to Yangzhou University, Yangzhou 225000, People’s Republic ...
Gu J, Lin H, Zhang Y, Xu T, Wang T, Xue X, Zhang W, Liu H   +7 more
doaj  

Ampelopsis Regulates Invasive Activity and Invasion Gene Expression of Hepatocellular Carcinoma HepG2 Cell Line Through Dermcidin Protein

Zhongliu Fangzhi Yanjiu, 2019
Objective To investigate the regulatory effect of ampelopsin (AMP) on invasion activity and invasion gene expression of hepatocellular carcinoma HepG2 cell line and its molecular mechanism.
LI Guanning, YANG Zhenhuai, GENG Yi
doaj   +1 more source

Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses.

Matrix Biology, 2016
Secreted and membrane tethered matrix metalloproteinases (MMPs) are key homeostatic proteases regulating the extracellular signaling and structural matrix environment of cells and tissues.
U. Eckhard, P. Huesgen, O. Schilling, C. Bellac, Georgina S. Butler, J. Cox, A. Dufour, Verena Goebeler, R. Kappelhoff, U. Keller, T. Klein, P. Lange, G. Marino, C. Morrison, A. Prudova, D. Rodríguez, Amanda E. Starr, Yili Wang, C. Overall   +18 more
semanticscholar   +1 more source

Impact of In Vitro Fertility and Matrix Metalloproteinases Activation of Spermatozoa by Supplement of Tea-N-Tris to Sperm Cryopreservation of Miniature Pig

Journal of Animal Reproduction and Biotechnology, 2014
The main purpose of this study is to estimate the effect of adding Tea-N-Tris (TES) to the freezing buffer for miniature pig sperm. In particular, we attempted to identify the association between the MMPs expression and the fertility and viability of ...
Sang-Hwan Kim, Hyun-Ah Kang, Yong-Su Park, Jong-Taek Yoon   +3 more
doaj   +1 more source

Matrix Metalloproteinases as Biomarkers and Treatment Targets in Mesothelioma: A Systematic Review

Biomolecules, 2021
Metalloproteinases (MMPs) have an important role in tissue remodeling and have been shown to have an effect on tumor progression, invasion, metastasis formation, and apoptosis in several tumors, including mesothelioma.
Danijela Štrbac, Vita Dolžan
doaj   +1 more source

Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis

Bioscience Reports, 2016
Fibrosis is a basic connective tissue lesion defined by the increase in the fibrillar extracellular matrix (ECM) components in tissue or organ. Matrix metalloproteinases (MMPs) are a major group of proteases known to regulate the turn-over of ECM and so ...
Sacha Robert, T. Gicquel, Tatiana Victoni, S. Valença, E. Barreto, B. Bailly-maitre, E. Boichot, V. Lagente   +7 more
semanticscholar   +1 more source