Results 61 to 70 of about 246,934 (340)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Association of matrix metalloproteinases (MMPs) gene polymorphisms with periodontitis: a systematic review

GMS Hygiene and Infection Control
Matrix metalloproteinases (MMPs) are proteinases released by gingival cells, macrophages and neutrophils, induced by potentially pathogenic periodontal bacteria of the subgingival plaque, which play a critical role in the pathogenesis of periodontal ...
Pandey, Ruchi, Gupta, Nandini, Jha, Tripti, Manzoor, Tooba Bint E   +3 more
doaj   +1 more source

Expression of Drosophila Matrix Metalloproteinases in Cultured Cell Lines Alters Neural and Glial Cell Morphology

Frontiers in Cell and Developmental Biology, 2021
Matrix metalloproteinases (MMPs) are zinc- and calcium- dependent endopeptidases that play pivotal roles in many biological processes. The expression of several MMPs in the central nervous system (CNS) have been shown to change in response to injury and ...
Scoty Hearst, Scoty Hearst, Andrea Bednářová, Andrea Bednářová, Benjamin Draughn, Kennadi Johnson, Desiree Mills, Cendonia Thomas, Jendaya Scales, Eadie T. Keenan, Jewellian V. Welcher, Natraj Krishnan   +11 more
doaj   +1 more source

Matrix remodeling by MMPs during wound repair.

Matrix Biology, 2015
Repair following injury involves a range of processes - such as re-epithelialization, scar formation, angiogenesis, inflammation, and more - that function, often together, to restore tissue architecture.
Maryam G. Rohani, W. Parks
semanticscholar   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Influence of photodynamic therapy on the level of matrix metalloproteinases in squamous cell skin cancer

Biomedical Photonics, 2022
The effect of photodynamic therapy (PDT) on the level of matrix metalloproteinases in squamous cell skin cancer (SCSC) was studied. The study involved 202 people, including 185 patients with SCSC, who were on outpatient and inpatient treatment in medical
V. V. Maslyakov, D. Yu. Grebnev, A. A. Tsymbal, L. M. Kim   +3 more
doaj   +1 more source

Specificity and reproducibility of the single MMPs-based and duplex MMPs-based duplex UNDP-PCR assay.

, 2015
Two viruses (TGEV and PCV2) as well as unrelated viruses (PPV, CSFV, PEDV, PRRSV), and serum of healthy pigs were tested to evaluate the specificity of the single MMPs-based and duplex MMPs-based duplex UNDP-PCR.
Xiujuan Zhang (174319), Xiaomin Zhao (566041), Lingling Chang (350993), Na Xing (823501), Qian Du (280345), Dewen Tong (93139), Yong Huang (15745), Zengguo Wang (823502)   +7 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Curcuma longa L. extract exhibits anti-inflammatory and cytoprotective functions in the articular cartilage of monoiodoacetate-injected rats

Food & Nutrition Research
Background: Osteoarthritis (OA), the most prevalent form of arthritis, is a degenerative joint disease marked by the progressive deterioration of articular cartilage, leading to clinical manifestations such as joint pain.
Hyelim Kim, Jaeeun Jung, Minhee Lee, Minha Kim, Namgil Kang, Ok-Kyung Kim, Jeongmin Lee   +6 more
doaj   +1 more source

Abnormalities in soluble CD147 / MMPs / TIMPs axis in Ankylosing Spondylitis patients with and without a history of Acute Anterior Uveitis / Anomalii ale axei CD147 solubil / MMPs / TIMPs la pacienții cu spondilită anchilozantă cu sau fără uveită acută anterioară

Romanian Journal of Laboratory Medicine, 2014
Spondilita Anchilozantă (SA) este prototipul formei axiale a spondiloartritelor. În pofida studiilor extinse, sunt încă incomplet înțelese mecansimele complexe legate de procesele celulare și moleculare anormale din SA.
Mitulescu Traian Costin, Voinea Liliana Mary, Predeteanu Denisa, Banica Leontina Mirela, Stavaru Crina, Matache Cristiana   +5 more
doaj   +1 more source