Results 71 to 80 of about 246,934 (340)

Porphyromonas gingivalis increases the invasiveness of oral cancer cells by upregulating IL-8 and MMPs.

Cytokine, 2016
Recent studies indicate that chronic inflammation promotes the aggressiveness of cancers. However, the direct molecular mechanisms underlying a functional link between chronic periodontitis, the most common form of oral inflammatory diseases, and the ...
N. Ha, Dae-Gun Park, B. Woo, Da Jeong Kim, Jeomil Choi, Bong-Soo Park, Yong Deok Kim, Ji Hye Lee, H. Park   +8 more
semanticscholar   +1 more source

Role of Matrilysins (MMP-7, MMP-26) and Stromelysins (MMP-3, MMP-10) in Diagnosing Cervical Cancer Patients

Biomedicines
Background/Objectives: Detection of cervical lesions is crucial for effective prevention and treatment. Therefore, the search for new diagnostic markers is extremely important. This study aimed to evaluate the concentration and diagnostic utility of selected matrix metalloproteinases (MMPs) as novel biomarkers. Methods: The study group consisted of 320
Ewa Gacuta, Michał Ławicki, Hanna Grabowska, Paweł Ławicki, Monika Kulesza, Aleksandra Kicman, Monika Zajkowska, Piotr Laudański, Sławomir Ławicki   +8 more
openaire   +3 more sources

Purification of MMPs and TIMPs.

, 2010
A number of matrix metalloproteinases (MMPs) and their endogenous inhibitors called tissue inhibitors of metalloproteinases (TIMPs) from natural sources have been identified. This chapter describes the purification methods of MMPs-1, -2, -3, -7, -8, -9, -
Shimokawa, K, Nagase, H, Ken-ichi Shimokawa, Nagase, Hideaki, Hideaki Nagase   +4 more
core   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Association of Common Variants in MMPs with Periodontitis Risk

Disease Markers, 2016
Background. Matrix metalloproteinases (MMPs) are considered to play an important role during tissue remodeling and extracellular matrix degradation. And functional polymorphisms in MMPs genes have been reported to be associated with the increased risk of
Wenyang Li, Ying Zhu, Pradeep Singh, D. Ajmera, Jinlin Song, P. Ji   +5 more
semanticscholar   +1 more source

Upregulation of matrix metalloproteinases (MMPs) in breast cancer xenografts : a major induction of stromal MMP-13

, 2005
In human breast cancer (HBC), as with many carcinoma systems, most matrix metalloproteinases (MMPs) are largely expressed by the stromal cells, whereas the tumour cells are relatively silent in MMP expression.
Williams, Elizabeth D., Thompson, Erik W., Blick, Tony, Lafleur, Marc A., Walker, Emma C., Bills, Margaret, Drew, Angela F., De Sousa, Emma L., Waltham, Mark   +8 more
core   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Higher levels of circulating TIMP-4 in preeclampsia is strongly associated with clinical parameters and microRNA

Clinical and Experimental Hypertension, 2018
Background: Preeclampsia results in maternal and fetal complications and some studies have reported the role of MMPs and TIMPs in its pathophysiology.
Valéria C. Sandrim, Solange Diniz, Nibia Mariana Eleuterio, Karina B. Gomes, Luci Maria S. Dusse, Ricardo C. Cavalli   +5 more
doaj   +1 more source

Placental membrane-type metalloproteinases (MT-MMPs): Key players in pregnancy

Cell Adhesion & Migration, 2016
Membrane-type matrix metalloproteinases (MT-MMPs) are a sub-family of zinc-dependent endopeptidases involved in the degradation of the extracellular matrix.
A. Majali-Martínez, U. Hiden, Nassim Ghaffari-Tabrizi-Wizsy, U. Lang, G. Desoye, M. Dieber-Rotheneder   +5 more
semanticscholar   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source