Results 51 to 60 of about 246,934 (340)
Data sets of MMP-cliffs, SAR transfer series and RECAP-MMPs
, 2014 <p>A new and up-to-date version of three MMP-based data sets derived from compounds included in the latest release of ChEMBL is presented. These data sets include activity cliffs, structure-activity relationship (SAR) transfer series, and second ...
Jürgen Bajorath (743714) +7 more
core +1 more source
Brain, behavior, and immunity, 2017 HIV-1-associated neurocognitive disorders (HAND) continue to be a major concern in the infected population, despite the widespread use of combined antiretroviral therapy (cART).
Yan-Yan Xing +8 more
semanticscholar +1 more source
Drug Design, Development and Therapy, 2020 Shuang Feng, Hui Cong, Lei Ji The Second People’s Hospital of Nantong, Nantong, Jiangsu, People’s Republic of ChinaCorrespondence: Lei Ji Email jileiyaoyao@163.comIntroduction: Osteoarthritis (OA), a chronic joint disease, combines with ...
Feng S, Cong H, Ji L
doaj
4 open, 2019 The attempt to restore homeostasis, once disrupted, such that complex signaling, crosstalk between ubiquitous proteins, and a diverse range of pathways gone awry is near impossible, especially in the presence of an ongoing pathogenic stimuli with ...
Brücher Björn L.D.M., Jamall Ijaz S.
doaj +1 more source
Biomolecules, 2021 Basal cell carcinoma (BCC) is the most common skin malignancy, which rarely metastasizes but has a great ability to infiltrate and invade the surrounding tissues.
Mircea Tampa +11 more
doaj +1 more source
Inhibition of matrix metalloproteinases: a troubleshooting for dentin adhesion [PDF]
Restorative Dentistry & Endodontics, 2020 Matrix metalloproteinases (MMPs) are enzymes that can degrade collagen in hybrid layer and reduce the longevity of adhesive restorations. As scientific understanding of the MMPs has advanced, useful strategies focusing on preventing these enzymes ...
Izadora Quintela Souza de Moraes +5 more
doaj +1 more source
Moving targets: Emerging roles for MMPs in Cancer Progression and Metastasis
Matrix Biology, 2015 Matrix metalloproteinases have long been associated with cancer. Clinical trials of small molecule inhibitors for this family of enzymes however, were spectacularly unsuccessful in a variety of tumor types.
G. Shay, C. Lynch, B. Fingleton
semanticscholar +1 more source
Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in the respiratory tract: Potential implications in asthma and other lung diseases [PDF]
, 2006 peer reviewedIn healthy lung, Matrix Metalloproteinases (MMPs) and their physiological inhibitors, tissue inhibitors of matrix metalloproteinases (TIMPs), are produced in the respiratory tract by a panel of different structural cells.
Cataldo, Didier +7 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Matrix Metalloproteinases Inhibitors in Cancer Treatment: An Updated Review (2013–2023)
Molecules, 2023 Matrix metalloproteinases (MMPs) are identifiable members of proteolytic enzymes that can degrade a wide range of proteins in the extracellular matrix (ECM).
Shriefa Almutairi +3 more
doaj +1 more source