Results 91 to 100 of about 246,934 (340)
, 2016 O tratamento radioterápico para pacientes com neoplasias de cabeça e pescoço pode trazer consequências secundárias graves como alterações da estrutura dental, com conseguinte prejuízo da função oral, a qual influencia negativamente a qualidade de vida ...
Claudia María Carpio Bonilla
core +2 more sources
Matrix Metalloproteinases in Renal Diseases: A Critical Appraisal
Kidney & Blood Pressure Research, 2019 Matrix metalloproteinases (MMPs) are endopeptidases within the metzincin protein family that not only cleave extracellular matrix (ECM) components, but also process the non-ECM molecules, including various growth factors and their binding proteins.
Oskar Zakiyanov +3 more
doaj +1 more source
Tumour-targeting properties of antibodies specific to MMP-1A, MMP-2 and MMP-3 [PDF]
European Journal of Nuclear Medicine and Molecular Imaging, 2010 Purpose: Matrix metalloproteinases (MMPs), a group of more than 20 zinc-containing endopeptidases, are upregulated in many diseases, but several attempts to use radiolabelled MMP inhibitors for imaging tumours have proved unsuccessful in mouse models, possibly due to the limited specificity of these agents or their unfavourable pharmacokinetic profiles.
Pfaffen, Stefanie +4 more
openaire +4 more sources
Phylogenetic analysis of Tribolium MMPs along with MMPs from other organisms.
, 2013 A Bayesian protein tree, with posterior probabilities, was generated using aligned MMP sequences from T. castaneum, Anopheles gambiae, Drosophila melanogaster, Homo sapiens, and Heliothis zea virus 1. A Hydra vulgaris MMP was used as outgroup.
Boran Altincicek (68057) +3 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Conventional therapies suffer from poor blood–brain barrier (BBB) penetration and disordered ion/reactive oxygen species (ROS) homeostasis, hindering precise neurological treatment. Electrochemical strategies achieve accurate spatiotemporal regulation of neural homeostasis.
Xiaokang Hu +5 more
wiley +1 more source
EMMPRIN, an upstream regulator of MMPs, in CNS biology.
Matrix Biology, 2015 Matrix metalloproteinases (MMPs) are engaged in pathologies associated with infections, tumors, autoimmune disorders and neurological dysfunctions. With the identification of an upstream regulator of MMPs, EMMPRIN (Extracellular matrix metalloproteinase ...
D. Kaushik, J. N. Hahn, Wee V. Yong
semanticscholar +1 more source
Roles for Specific MMPs in Cutaneous Wound Healing
, 2005 Activation of the pro-enzyme can occur in three different regulated processes; stepwise activation by other proteases, cell surface activation by another MMP, or intracellularly (9,13,24,25). Stepwise activation involves other proteinases such as plasmin.
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MMPs and TIMPs: Severe vs moderately severe vs mild AP.
, 2022 MMPs and TIMPs: Severe vs moderately severe vs mild AP.
Lindsey Hornung (5916374) +8 more
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Chemical Strategies for Multistimuli Responsive Dynamic Covalent Materials in Regenerative Medicine
Advanced Healthcare Materials, EarlyView.Multistimuli responsive dynamic covalent materials integrate reversible chemistry with the complex chemical, mechanical, and biochemical cues of regenerative environments. This review highlights chemical strategies based on orthogonal dynamic bonds, multicomponent networks, and hierarchical architectures to regulate mechanics, degradation, and ...
Saurabh Joshi +2 more
wiley +1 more source
Journal of Neuroinflammation, 2007 Background Matrix metalloproteinases (MMPs) are thought to mediate cellular infiltration in central nervous system (CNS) inflammation by cleaving extracellular matrix proteins associated with the blood-brain barrier.
Millward Jason M +3 more
doaj +1 more source