Results 21 to 30 of about 246,934 (340)

Luteolin alleviates renal ischemia-reperfusion injury in streptozotocin induced diabetic rats by inhibiting metalloenzymes expression

Current Issues in Pharmacy and Medical Sciences, 2023
Diabetes patients are more prone to acute kidney injury (AKI). Endopeptidases known as matrix metalloproteinases (MMPs) cause extracellular matrix destruction and are responsible for ischemic organ damage.
Daude Rakesh B., Shah Jigna S.
doaj   +1 more source

VEGF promotes migration and invasion by regulating EMT and MMPs in nasopharyngeal carcinoma

Journal of Cancer, 2020
Background: Vascular endothelial growth factor (VEGF) is an important pro-angiogenic factor. Accumulating data have indicated that VEGF is involved in tumour metastasis.
Li Chen, Guo-Xiang Lin, Kai-Hua Chen, Renba Liang, Fangzhu Wan, Chuxiao Zhang, Ge Tian, Xiao-Dong Zhu   +7 more
semanticscholar   +1 more source

Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis [PDF]

, 2014
Tuberculosis (TB) remains a global health pandemic and greater understanding of underlying pathogenesis is required to develop novel therapeutic and diagnostic approaches.
Sandhu, G, Christopher H. Woelk, Carlton A. W. Evans, Gurjinder Sandhu (161147), Borislav D. Dimitrov (687966), Gurjinder Sandhu, Woelk Christopher H., Liku B. Tezera, Akul Singhania, Thomas, Richard, Agranoff Dan, Sandhu Gurjinder, Liku B. Tezera (405129), Paul T. Elkington, Christopher H. Woelk (195217), Tezera, LB, Friedland Jon S., Jon S Friedland, Sathyamoorthy, Tarangini, Dimitrov, Borislav D., Sathyamoorthy, T, Singhania, A, Elkington, Paul T., Evans Carlton A. W., Agranoff, Dan, Evans, CAW, Richard Thomas, Elkington Paul T., Dimitrov, BD, Borislav D Dimitrov, Friedland, Jon S., Carlton A. W. Evans (687967), Christopher H Woelk, Dan Agranoff, Paul T Elkington, Paul T. Elkington (364501), Tarangini Sathyamoorthy (687964), Agranoff, D, Jon S. Friedland (161158), Tezera, Liku B., Sathyamoorthy Tarangini, Woelk, Christopher H., Borislav D. Dimitrov, Richard Thomas (687965), Akul Singhania (502117), Evans, Carlton A.W., Singhania, Akul, Jon S. Friedland, Tarangini Sathyamoorthy, Liku B Tezera, Sandhu, Gurjinder, Friedland, JS, Carlton A W Evans, Tezera Liku B., Thomas, R, Elkington, PT, Thomas Richard, Woelk, CH, Singhania Akul, Dan Agranoff (377996), Dimitrov Borislav D.   +60 more
core   +1 more source

The role of metalloproteinase and hypoxia conditions in endometrial cells and embryo implantation

Journal of Current Biomedical Reports, 2020
In the process of implantation, metalloproteinase enzymes play a key role in basement membrane degradation and endometrial extracellular matrix. The activity of these enzymes is impeded by binding Tissue Inhibitors of Metalloproteinase (TIMP). The oxygen
Maryam Mahdavi, Diba Bagheri, Elmira Vanaki, Mehdi Shamsara, Ehsan Hashemi, Saeed Ansari, Mojtaba Dashtizad, Morteza Daliri Joupari   +7 more
doaj   +1 more source

Silibinin Inhibits Cell Invasion through the Inhibition of MMPs, p-p38, and IL-1β in Human Fibrosarcoma Cells

Frontiers in Bioscience-Landmark, 2023
Background and Aims: Normal cells become tumorigenic owing to mutations in oncogenes and tumor suppressor genes modulating cell division. Cancer cells break down extracellular matrix to metastasize other tissues. Therefore, the development of natural and
Ah In Jo, Moon-Moo Kim
doaj   +1 more source

Correlation between MMP-9 and extracellular cytokine HMGB1 in prediction of human ischemic stroke outcome [PDF]

, 2014
Ischemic stroke (IS) outcome predictors include clinical features, biochemical parameters and some risk factors. The relations between two main players in the ischemic brain, MMPs and HMGB1, were estimated in the plasma of ischemic stroke patients ...
Kalandadze, Iagor, Gugutsidze, Darejan, Shakarishvili, Roman, Sapojnikova, Nelly, Kartvelishvili, Tamar, Zinkevich, Vitaly, Tsiskaridze, Alexander, Asatiani, Nino   +7 more
core   +1 more source

The Expression of Matrix Metalloproteinases Activated Differently on In-Vitro Maturation of oocytes Cytoplasm and Cumulus Cells in Bovine

Journal of Animal Reproduction and Biotechnology, 2018
To determine the differences in the in-vitro ovum maturation process of bovine, we compared the expression of MMPs in these oocytes and cumulus cell throughout oocytes maturated. In an attempt to investigate the effect of MMP activation and inhibitors in
Sang-Hwan Ki, Jong-Taek Yoon
doaj   +1 more source

Proteolytic parameter changes in the plasma of patients with bladder cancer – depending on tumor stage

Current Issues in Pharmacy and Medical Sciences, 2020
Bladder cancer (BC) is a worldwide common disease with a high mortality rate. Recognizing the dynamic changes in plasma that proteases and their inhibitors undergo might be valuable in understanding the carcinogenesis of invasive bladder cancer and in ...
Dmytryk Viktor, Luhovska Tetiana, Yakovlev Pavel, Savchuk Olexiy, Halenova Tetiana, Raksha Nataliia, Ostapchenko Ludmila   +6 more
doaj   +1 more source

MMPs in learning and memory and neuropsychiatric disorders

Cellular and Molecular Life Sciences, 2019
Matrix metalloproteinases (MMPs) are a group of over twenty proteases, operating chiefly extracellularly to cleave components of the extracellular matrix, cell adhesion molecules as well as cytokines and growth factors.
Anna Beroun, S. Mitra, P. Michaluk, B. Pijet, M. Stefaniuk, L. Kaczmarek   +5 more
semanticscholar   +1 more source

Inhibition of MMPs and ADAM/ADAMTS

Biochemical Pharmacology, 2019
Matrix metalloproteinases (MMPs), A Disintegrin and Metalloproteinase (ADAM) and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) are zinc-dependent endopeptidases that play a critical role in the destruction of extracellular matrix
C. Malemud
semanticscholar   +1 more source