Results 71 to 80 of about 399 (121)
Effects of HPV8 and MmuPV1 E6 on TGF-β nuclear events.
, 2017 (A) Immunoblot analysis of TGF-β signaling components following TGF-β1 treatment in cytoplasmic and nuclear fractions of GFP (C), HPV8 E6 (8E6) or MmuPV1 E6 (ME6) expressing iHFKs.
Karl Munger (3215976) +4 more
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HPV8 and MmuPV1 E6 require interaction with MAML1 for NOTCH inhibition.
, 2017 (A) Alignment of LXXLL motifs of Paxillin, MAML1 and UBE3A. (B) Lysates of U2OS cells expressing FLAG/HA tagged versions of wildtype or mutant HPV8 E6 proteins were subjected to HA immunoprecipitation.
Karl Munger (3215976) +4 more
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, 2017 (A) Whole cell extracts (WCE) from human keratinocytes stably expressing FLAG/HA-tagged HPV8 E6 (8), MmuPV1 E6 (M), or GFP (C) were subjected to HA immunoprecipitation (IP) and analyzed for associated EP300, MAML1 and ICN1 (three components of NOTCH ...
Karl Munger (3215976) +4 more
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Role of IQGAP1 in Papillomavirus-Associated Head and Neck Tumorigenesis
, 2021 Approximately 25% of head and neck squamous cell carcinomas (HNSCC) are associated with human papillomavirus (HPV) infection. In these cancers as well as in HPV-associated anogenital cancers, PI3K signaling is highly activated.
Tao Wei +6 more
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SMAD4 association with SMAD2/3 is abrogated in the presence of HPV8 and MmuPV1 E6.
, 2017 Immunoprecipitation of FLAG-tagged SMAD2 (A) or FLAG-tagged SMAD3 (B) with co-transfection of either HPV8 E6 or MmupV1 E6 after TGF-β1 treatment followed by SMAD4 immunoblot. Data shown is representative of three independent experiments.
Karl Munger (3215976) +4 more
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Viruses, 2020 Human head and neck cancers that develop from the squamous cells of the oropharynx (Oropharyngeal Squamous Cell Carcinomas or OPSCC) are commonly associated with the papillomavirus infection.
Andrea Bilger +12 more
doaj +1 more source
Infectivity of MmuPV1 quasivirus and histology and analysis of MmuPV1-induced papillomaviruses.
, 2017 (A) Quasiviruses were used to infect mouse keratinocytes and total RNA was harvested, cDNA was synthesized and assayed for the presence of E1^E4 spliced transcript. PCR products were visualized on agarose gel and compared to GAPDH amplification.
Karl Munger (3215976) +4 more
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MmuPV1 L1- cytokeratin dual immunofluorescence using home-based tyramide signal amplification v1
, 2017 To accomplish MmuPV L1-K14 double fluorescent staining we made use of tyramide-based signal amplification (TSA) technique. This technique allows for easy multiplexing of immunofluorescent staining but perhaps its biggest advantage is that it permits double immunofluorescent staining using two unconjugated primary antisera raised in the same species. We
Aayushi Uberoi +2 more
openaire +1 more source
PLoS Pathogens, 2020 High-risk human papillomaviruses (HPVs) cause 5% of human cancers. Despite the availability of HPV vaccines, there remains a strong urgency to find ways to treat persistent HPV infections, as current HPV vaccines are not therapeutic for individuals ...
Wei Wang +9 more
doaj +1 more source
Role of E6 in Maintaining the Basal Cell Reservoir during Productive Papillomavirus Infection.
, 2022 Papillomaviruses exclusively infect stratified epithelial tissues and cause chronic infections. To achieve this, infected cells must remain in the epithelial basal layer alongside their uninfected neighbors for years or even decades.
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