The Mouse Papillomavirus Infection Model [PDF]
Viruses, 2017 The mouse papillomavirus (MmuPV1) was first reported in 2011 and has since become a powerful research tool. Through collective efforts from different groups, significant progress has been made in the understanding of molecular, virological, and ...
Jiafen Hu +2 more
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Mouse Papillomavirus L1 and L2 Are Dispensable for Viral Infection and Persistence at Both Cutaneous and Mucosal Tissues [PDF]
Viruses, 2021 Papillomavirus L1 and L2, the major and minor capsid proteins, play significant roles in viral assembly, entry, and propagation. In the current study, we investigate the impact of L1 and L2 on viral life cycle and tumor growth with a newly established ...
Nancy M Cladel +2 more
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Mouse papillomavirus infection persists in mucosal tissues of an immunocompetent mouse strain and progresses to cancer [PDF]
Scientific Reports, 2017 Mouse papillomavirus has shown broad tissue tropism in nude mice. Previous studies have tested cutaneous infections in different immunocompromised and immunocompetent mouse strains.
Nancy M. Cladel +7 more
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Protocol for in vivo lineage tracing of the mouse-papillomavirus-type 1-infected cells in mice [PDF]
STAR Protocols, 2023 Summary: Here, we present a protocol to create an in vivo lineage-tracing mouse model for mouse-papillomavirus-type 1 (MmuPV1)-infected cells. We describe the steps to generate and deliver the MmuPV1 lox-Cre-lox plasmid for the infection of mice ...
Vural Yilmaz, Katerina Strati
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Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model
Pathogens, 2023 Human papillomavirus (HPV)-induced oropharyngeal cancer now exceeds HPV-induced cervical cancer, with a noticeable sex bias. Although it is well established that women have a more proficient immune system, it remains unclear whether immune control of ...
Jiafen Hu +2 more
exaly +6 more sources
Mouse papillomavirus MmuPV1 infects oral mucosa and preferentially targets the base of the tongue [PDF]
Virology, 2016 In 2010, a new mouse papillomavirus, MmuPV1, was discovered in a colony of NMRI- Foxn1nu/Foxn1nu athymic mice in India. This finding was significant because it was the first papillomavirus to be found in a laboratory mouse.
Nancy M Cladel +2 more
exaly +5 more sources
The Mouse Papillomavirus Epigenetic Signature Is Characterised by DNA Hypermethylation after Lesion Regression [PDF]
Viruses, 2021 Papillomaviruses (PVs) are double-stranded DNA tumour viruses that can infect cutaneous and mucosal epidermis. Human papillomavirus (HPV) types have been linked to the causality of cutaneous squamous cell carcinoma (cSCC); however, HPV DNA is not always ...
Allison M. Tschirley +7 more
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A Novel Model for Papillomavirus-Mediated Anal Disease and Cancer Using the Mouse Papillomavirus [PDF]
mBio, 2021 Up to 95% of all anal cancers are associated with infection by human papillomavirus (HPV); however, no established preclinical model exists for high-grade anal disease and cancer mediated by a natural papillomavirus infection.
Simon Blaine-Sauer +4 more
doaj +4 more sources
Viruses, 2020 Human head and neck cancers that develop from the squamous cells of the oropharynx (Oropharyngeal Squamous Cell Carcinomas or OPSCC) are commonly associated with the papillomavirus infection.
Andrea Bilger +2 more
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Expanded Basal Compartment and Disrupted Barrier in Vocal Fold Epithelium Infected with Mouse Papillomavirus MmuPV1 [PDF]
Viruses, 2022 Laryngeal infection with low-risk human papillomaviruses can cause recurrent respiratory papillomatosis (RRP), a disease with severe effects on vocal fold epithelium resulting in impaired voice function and communication. RRP research has been stymied by
Renee E. King +4 more
doaj +2 more sources