The Mouse Papillomavirus Infection Model [PDF]
Viruses, 2017 The mouse papillomavirus (MmuPV1) was first reported in 2011 and has since become a powerful research tool. Through collective efforts from different groups, significant progress has been made in the understanding of molecular, virological, and ...
Jiafen Hu +4 more
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Mouse Papillomavirus L1 and L2 Are Dispensable for Viral Infection and Persistence at Both Cutaneous and Mucosal Tissues [PDF]
Viruses, 2021 Papillomavirus L1 and L2, the major and minor capsid proteins, play significant roles in viral assembly, entry, and propagation. In the current study, we investigate the impact of L1 and L2 on viral life cycle and tumor growth with a newly established ...
Sarah Brendle +12 more
doaj +10 more sources
Mouse papillomavirus infection persists in mucosal tissues of an immunocompetent mouse strain and progresses to cancer [PDF]
Scientific Reports, 2017 Mouse papillomavirus has shown broad tissue tropism in nude mice. Previous studies have tested cutaneous infections in different immunocompromised and immunocompetent mouse strains.
Nancy M. Cladel +7 more
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Protocol for in vivo lineage tracing of the mouse-papillomavirus-type 1-infected cells in mice [PDF]
STAR Protocols, 2023 Summary: Here, we present a protocol to create an in vivo lineage-tracing mouse model for mouse-papillomavirus-type 1 (MmuPV1)-infected cells. We describe the steps to generate and deliver the MmuPV1 lox-Cre-lox plasmid for the infection of mice ...
Vural Yilmaz, Katerina Strati
doaj +6 more sources
Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model [PDF]
Pathogens, 2023 Human papillomavirus (HPV)-induced oropharyngeal cancer now exceeds HPV-induced cervical cancer, with a noticeable sex bias. Although it is well established that women have a more proficient immune system, it remains unclear whether immune control of ...
Sarah A. Brendle +10 more
doaj +6 more sources
Mouse papillomavirus MmuPV1 infects oral mucosa and preferentially targets the base of the tongue [PDF]
Virology, 2016 In 2010, a new mouse papillomavirus, MmuPV1, was discovered in a colony of NMRI- Foxn1(nu)/Foxn1(nu) athymic mice in India. This finding was significant because it was the first papillomavirus to be found in a laboratory mouse. In this paper we report successful infections of both dorsal and ventral surfaces of the rostral tongues of outbred athymic ...
Jiafen Hu +2 more
exaly +6 more sources
The Mouse Papillomavirus Epigenetic Signature Is Characterised by DNA Hypermethylation after Lesion Regression [PDF]
Viruses, 2021 Papillomaviruses (PVs) are double-stranded DNA tumour viruses that can infect cutaneous and mucosal epidermis. Human papillomavirus (HPV) types have been linked to the causality of cutaneous squamous cell carcinoma (cSCC); however, HPV DNA is not always ...
Allison M. Tschirley +7 more
doaj +7 more sources
A Novel Model for Papillomavirus-Mediated Anal Disease and Cancer Using the Mouse Papillomavirus [PDF]
mBio, 2021 Up to 95% of all anal cancers are associated with infection by human papillomavirus (HPV); however, no established preclinical model exists for high-grade anal disease and cancer mediated by a natural papillomavirus infection.
Simon Blaine-Sauer +4 more
doaj +4 more sources
The full transcription map of mouse papillomavirus type 1 (MmuPV1) in mouse wart tissues. [PDF]
PLoS Pathogens, 2017 Mouse papillomavirus type 1 (MmuPV1) provides, for the first time, the opportunity to study infection and pathogenesis of papillomaviruses in the context of laboratory mice.
Xiang-Yang Xue +8 more
doaj +5 more sources
Development of an in vivo infection model to study Mouse papillomavirus-1 (MmuPV1) [PDF]
Journal of Virological Methods, 2018 Preclinical model systems to study multiple features of the papillomavirus life cycle are extremely valuable tools to aid our understanding of Human Papillomavirus (HPV) biology, disease progression and treatments. Mouse papillomavirus (MmuPV1) is the first ever rodent papillomavirus that can infect the laboratory strain of mice and was discovered ...
Paul Lambert, Aayushi Uberoi
exaly +5 more sources