A novel lineage-tracing mouse model for studying early MmuPV1 infections
eLife, 2022 Human papillomaviruses are DNA viruses that ubiquitously infect humans and have been associated with hyperproliferative lesions. The recently discovered mouse specific papillomavirus (MmuPV1) provides the opportunity to study papillomavirus infections in
Vural Yilmaz +4 more
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Induction of autoantibodies to mouse CCR5 with recombinant papillomavirus particles [PDF]
Proceedings of the National Academy of Sciences, 1999 The vertebrate immune system has evolved to respond vigorously to microbial infection but to ignore self-antigens. Evidence has emerged that B cell responses to viruses are initiated by immune recognition of ordered arrays of antigen on the viral surface.
B, Chackerian, D R, Lowy, J T, Schiller
openaire +2 more sources
Sex-dependent development of Kras-induced anal squamous cell carcinoma in mice.
PLoS ONE, 2021 Anal squamous cell carcinoma (SCC) will be diagnosed in an estimated 9,080 adults in the United States this year, and rates have been rising over the last several decades.
Morgan T Walcheck +7 more
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An Infection-Based Murine Model for Papillomavirus-Associated Head and Neck Cancer
mBio, 2020 Human papillomavirus (HPV) is the most common sexually transmitted pathogen, and high-risk HPVs contribute to 5% of human cancers, including 25% of head and neck squamous cell carcinomas (HNSCCs).
Tao Wei +3 more
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A novel pre-clinical murine model to study the life cycle and progression of cervical and anal papillomavirus infections. [PDF]
PLoS ONE, 2015 Papillomavirus disease and associated cancers remain a significant health burden in much of the world. The current protective vaccines, Gardasil and Cervarix, are expensive and not readily available to the underprivileged.
Nancy M Cladel +5 more
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Isolation of three novel rat and mouse papillomaviruses and their genomic characterization. [PDF]
, 2012 Despite a growing knowledge about the biological diversity of papillomaviruses (PV), only little is known about non-human PV in general and about PV mice models in particular.
Ingo Nindl (126623) +23 more
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CD28-deficient mice are vulnerable to mouse papillomavirus MmuPV1 infection of the skin and mucosae. [PDF]
PLoS PathogCD28 is a co-stimulatory molecule expressed on the surface of T cells. To date, three individuals with germline CD28 deficiency have been reported to develop recalcitrant, HPV-driven warts: one exhibited persistent lesions, another experienced disease resolution, and the third developed a chronic “tree-man” phenotype.
Brendle S +15 more
europepmc +2 more sources
PLoS Pathogens, 2023 Human papillomaviruses (HPVs) contribute to approximately 5% of all human cancers. Species-specific barriers limit the ability to study HPV pathogenesis in animal models.
James C Romero-Masters +12 more
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Papillomavirus E5: the smallest oncoprotein with many functions [PDF]
, 2011 Papillomaviruses (PVs) are established agents of human and animal cancers. They infect cutaneous and mucous epithelia. High Risk (HR) Human PVs (HPVs) are consistently associated with cancer of the uterine cervix, but are also involved in the ...
Roperto, S. +27 more
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Increased Growth of a Newly Established Mouse Epithelial Cell Line Transformed with HPV-16 E7 in Diabetic Mice. [PDF]
PLoS ONE, 2016 Epidemiological evidence supports that infection with high-risk types of human papillomavirus (HPV) can interact with host and environmental risk factors to contribute to the development of cervical, oropharyngeal, and other anogenital cancers.
Lan He +8 more
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