Results 21 to 30 of about 887,744 (175)

Efficacy of Topically Administered Dihydroartemisinin in Treating Papillomavirus-Induced Anogenital Dysplasia in Preclinical Mouse Models

Viruses, 2022
The artemisinin family of compounds is cytopathic in certain cancer cell lines that are positive for human papillomaviruses (HPV) and can potentially drive the regression of dysplastic lesions. We evaluated the efficacy of topical dihydroartemisinin (DHA)
Laura C. Gunder, Simon Blaine-Sauer, Hillary R. Johnson, Myeong-Kyun Shin, Andrew S. Auyeung, Wei Zhang, Glen E. Leverson, Ella T. Ward-Shaw, Renee E. King, Stephanie M. McGregor, Kristina A. Matkowskyj, Paul F. Lambert, Evie H. Carchman   +12 more
doaj   +1 more source

An Infection-Based Murine Model for Papillomavirus-Associated Head and Neck Cancer

mBio, 2020
Human papillomavirus (HPV) is the most common sexually transmitted pathogen, and high-risk HPVs contribute to 5% of human cancers, including 25% of head and neck squamous cell carcinomas (HNSCCs).
Tao Wei, Darya Buehler, Ella Ward-Shaw, Paul F. Lambert   +3 more
doaj   +1 more source

A novel pre-clinical murine model to study the life cycle and progression of cervical and anal papillomavirus infections. [PDF]

PLoS ONE, 2015
Papillomavirus disease and associated cancers remain a significant health burden in much of the world. The current protective vaccines, Gardasil and Cervarix, are expensive and not readily available to the underprivileged.
Nancy M Cladel, Lynn R Budgeon, Karla K Balogh, Timothy K Cooper, Jiafen Hu, Neil D Christensen   +5 more
doaj   +1 more source

Life cycle heterogeneity in animal models of human papillomavirus-associated disease [PDF]

, 2002
Animal papillomaviruses are widely used as models to study papillomavirus infection in humans despite differences in genome organization and tissue tropism. Here, we have investigated the extent to which animal models of papillomavirus infection resemble
Peh, W.L., Liu, W.J., Christensen, N., Egawa, K., Lewis, J., Christensen, Neil, Peh, Woei Ling, Egawa, Kiyofumi, Percival, Alan, Lewis, Jon, Liu, Wen Jun, Percival, A., Nicholls, Philip, Doorbar, J., Brandsma, Janet, Middleton, K., Nicholls, P.K., Brandsma, J., Middleton, Kate, Sotlar, Karl, Sotlar, K., Doorbar, John   +21 more
core   +1 more source

Sex-dependent development of Kras-induced anal squamous cell carcinoma in mice.

PLoS ONE, 2021
Anal squamous cell carcinoma (SCC) will be diagnosed in an estimated 9,080 adults in the United States this year, and rates have been rising over the last several decades.
Morgan T Walcheck, Kristina A Matkowskyj, Anne Turco, Simon Blaine-Sauer, Manabu Nukaya, Jessica Noel, Oline K Ronnekleiv, Sean M Ronnekleiv-Kelly   +7 more
doaj   +2 more sources

Isolation of three novel rat and mouse papillomaviruses and their genomic characterization. [PDF]

, 2012
Despite a growing knowledge about the biological diversity of papillomaviruses (PV), only little is known about non-human PV in general and about PV mice models in particular.
Ingo Nindl (126623), Rainer G Ulrich, Rainer G. Ulrich, Eric Schulz, Eggert Stockfleth, Ulrich, Rainer G., Dania Richter, Eggert Stockfleth (126622), Gottschling, M., Stockfleth, Eggert, Schulz, Eric, Stockfleth, E., Rainer G. Ulrich (126621), Gottschling, Marc, Marc Gottschling, Ingo Nindl, Marc Gottschling (126620), Eric Schulz (126619), Schulz, E., Nindl, I., Richter, Dania, Richter, D., Nindl, Ingo, Dania Richter (105422)   +23 more
core   +2 more sources

MmuPV1 E7's interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease.

PLoS Pathogens, 2023
Human papillomaviruses (HPVs) contribute to approximately 5% of all human cancers. Species-specific barriers limit the ability to study HPV pathogenesis in animal models.
James C Romero-Masters, Miranda Grace, Denis Lee, Joshua Lei, Melanie DePamphilis, Darya Buehler, Rong Hu, Ella Ward-Shaw, Simon Blaine-Sauer, Nathalie Lavoie, Elizabeth A White, Karl Munger, Paul F Lambert   +12 more
doaj   +3 more sources

Stress keratin 17 enhances papillomavirus infection-induced disease by downregulating T cell recruitment.

PLoS Pathogens, 2020
High-risk human papillomaviruses (HPVs) cause 5% of human cancers. Despite the availability of HPV vaccines, there remains a strong urgency to find ways to treat persistent HPV infections, as current HPV vaccines are not therapeutic for individuals ...
Wei Wang, Aayushi Uberoi, Megan Spurgeon, Ellery Gronski, Vladimir Majerciak, Alexei Lobanov, Mitchell Hayes, Amanda Loke, Zhi-Ming Zheng, Paul F Lambert   +9 more
doaj   +1 more source

E5 protein of human papillomavirus type 16 selectively downregulates surface HLA class I [PDF]

, 2005
Papillomaviruses have evolved mechanisms that result in escape from host immune surveillance. The E5 protein is expressed early in papillomavirus infection in the deep layers of the infected epithelium.
Marchetti, Barbara, O'Brien, P.M., Ashrafi, G. Hossein, Haghshenas, Mohammad R., O'Brien, Philippa M., Ashrafi, G.H., Haghshenas, M.R., Campo, M.S., Marchetti, B., Campo, M. Saveria   +9 more
core   +1 more source

Naturally occurring, nonregressing canine oral papillomavirus infection: Host immunity, virus characterization, and experimental infection [PDF]

, 1999
Papillomaviruses occasionally cause severe, nonregressing or recurrent infections in their human and animal hosts. The mechanisms underlying these atypical infections are not known.
Nicholls, Philip K., Klaunberg, Brenda A., Parry, N.R., Gough, Gerald W., Santos, Elmer B., Gough, G.W., Stanley, M.A., Parry, Nigel R., Stanley, Margaret A., Klaaunberg, B.A., Nicholls, P.K., Moore, Richard A., Santos, E.B., Moore, R.A.   +13 more
core   +1 more source