Results 21 to 30 of about 38,676 (197)

Molecularly cloned bovine papillomavirus DNA transforms mouse fibroblasts in vitro [PDF]

Journal of General Virology, 1983
SUMMARY NIH 3T3 mouse fibroblasts were transformed in vitro by transfection with viral DNA from bovine papillomavirus (BPV) types 4, 2 and 1. The viral DNAs were molecularly cloned in pAT153 to construct pBV4, a recombinant plasmid containing the whole ...
Demetrios A Spandidost, M Saveria Campo
core   +3 more sources

Mouse Papillomavirus Outbreak in a Research Facility. [PDF]

J Am Assoc Lab Anim Sci
The use of mouse papillomavirus (MmuPV1) to study infections, disease outcomes, and vaccine strategies in mice has greatly enhanced our understanding of human papillomavirus. However, as with other species-specific infectious agents used as models for human disease, such studies may pose a risk to facilities that house large numbers of the model agent ...
Killoran KE, Breed MW, Roelke-Parker ME, Carney S, Edmondson E, Thompson CD, Schiller JT, Henderson K, Woods CL, Albers TM, Starost MF, Kramer JA.   +11 more
europepmc   +4 more sources

Identification and Characterization of MmuPV1 Causing Papillomatosis Outbreak in an Animal Research Facility [PDF]

Viruses
Mouse papillomavirus (MmuPV1) is the first papillomavirus known to infect laboratory mice, making it an irreplaceable tool for research on papillomaviruses. Despite wide use, standardized techniques for conducting MmuPV1 animal research are lacking.
Vladimir Majerciak, Kristin E. Killoran, Lulu Yu, Deanna Gotte, Elijah Edmondson, Matthew W. Breed, Renee E. King, Melody E. Roelke-Parker, Paul F. Lambert, Joshua A. Kramer, Zhi-Ming Zheng   +10 more
doaj   +2 more sources

Retinoic acid metabolism proteins are altered in trichoblastomas induced by mouse papillomavirus 1.

Experimental and Molecular Pathology, 2015
Skin cancer burden is significant as treatment costs have skyrocketed to $8.1million annually and some forms metastasize, such as cutaneous squamous cell carcinoma (cSCC) and melanoma. cSCC is caused by altered growth factor signaling induced by chemical
Suo, Liye, Bennett Jenson, A, Everts, Helen B, Ghim, Shinge, Sundberg, John P   +4 more
core   +4 more sources

Mouse papillomavirus infections spread to cutaneous sites with progression to malignancy. [PDF]

J Gen Virol, 2017
We report secondary cutaneous infections in the mouse papillomavirus (MmuPV1)/mouse model. Our previous study demonstrated that cutaneous MmuPV1 infection could spread to mucosal sites. Recently, we observed that mucosal infections could also spread to various cutaneous sites including the back, tail, muzzle and mammary tissues.
Cladel NM, Budgeon LR, Cooper TK, Balogh KK, Christensen ND, Myers R, Majerciak V, Gotte D, Zheng ZM, Hu J.   +9 more
europepmc   +3 more sources

EXPRESSION OF E8^E2 IS REQUIRED FOR WART FORMATION BY MOUSE PAPILLOMAVIRUS 1 IN VIVO. [PDF]

J Virol, 2021
HPV encodes an E8^E2 protein which acts as repressors of viral gene expression and genome replication. In cultured normal keratinocytes, E8^E2 is essential for long-term episomal maintenance of HPV 31 (HPV31) genomes, but not for that of HPV16.
Stubenrauch F, Straub E, Klein K, Kramer D, Iftner T, Wong M, Roden RBS.   +6 more
europepmc   +4 more sources

Tracking vaginal, anal and oral infection in a mouse papillomavirus infection model. [PDF]

J Gen Virol, 2015
Noninvasive and practical techniques to longitudinally track viral infection are sought after in clinical practice. We report a proof-of-principle study to monitor the viral DNA copy number using a newly established mouse papillomavirus (MmuPV1) mucosal infection model.
Hu J, Budgeon LR, Cladel NM, Balogh K, Myers R, Cooper TK, Christensen ND.   +6 more
europepmc   +3 more sources

Compromised T Cell Immunity Links Increased Cutaneous Papillomavirus Activity to Squamous Cell Carcinoma Risk

JID Innovations, 2023
Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer, with increased incidence in immunosuppressed patients. β-Human papillomavirus has been proposed as a contributor to cSCC risk partly on the basis of increased β-human ...
Luke H. Johnson, Heehwa G. Son, Dat Thinh Ha, John D. Strickley, Joongho Joh, Shadmehr Demehri   +5 more
doaj   +1 more source

Cryo EM Analysis Reveals Inherent Flexibility of Authentic Murine Papillomavirus Capsids

Viruses, 2021
Human papillomavirus (HPV) is a significant health burden and leading cause of virus-induced cancers. However, studies have been hampered due to restricted tropism that makes production and purification of high titer virus problematic.
Samantha R. Hartmann, Daniel J. Goetschius, Jiafen Hu, Joshua J. Graff, Carol M. Bator, Neil D. Christensen, Susan L. Hafenstein   +6 more
doaj   +1 more source

MmuPV1-Induced Cutaneous Squamous Cell Carcinoma Arises Preferentially from Lgr5+ Epithelial Progenitor Cells

Viruses, 2022
Murine papillomavirus, MmuPV1, causes natural infections in laboratory mice that can progress to squamous cell carcinoma (SCC) making it a useful preclinical model to study the role of papillomaviruses in cancer.
Ruben Moreno, Darya Buehler, Paul F. Lambert   +2 more
doaj   +1 more source