Results 21 to 30 of about 38,779 (193)

Stress keratin 17 enhances papillomavirus infection-induced disease by downregulating T cell recruitment. [PDF]

PLoS Pathogens, 2020
High-risk human papillomaviruses (HPVs) cause 5% of human cancers. Despite the availability of HPV vaccines, there remains a strong urgency to find ways to treat persistent HPV infections, as current HPV vaccines are not therapeutic for individuals ...
Wei Wang, Aayushi Uberoi, Megan Spurgeon, Ellery Gronski, Vladimir Majerciak, Alexei Lobanov, Mitchell Hayes, Amanda Loke, Zhi-Ming Zheng, Paul F Lambert   +9 more
doaj   +2 more sources

Molecular diagnosis of a laboratory mouse papillomavirus (MusPV)

Experimental and Molecular Pathology, 2012
MusPV, a novel papillomavirus (PV) that naturally infects laboratory mice, was isolated and characterized from a colony of NMRI-Foxn1(nu)/Foxn1(nu) (nude) mice in India. Because MusPV may have been missed during routine pathogen screening of mice in colonies worldwide, a variety of detection methods are described to detect MusPV.
Arvind Ingle, Kathleen Silva, A Bennett Jenson   +2 more
exaly   +4 more sources

The vaginal microbiome, papillomavirus infection, and cervical cancer: established associations in search of model systems and mechanistic answers [PDF]

mBio
High-risk human papillomavirus (HPV) infection is the causative factor for approximately 5% of all human cancers and the leading cause of cervical cancer. High-risk HPV-associated cervical cancer still claims more than 340,000 women’s lives globally each
Gianna V. Passarelli, Sonia N. Whang, Nicole M. Gilbert, Jiafen Hu   +3 more
doaj   +2 more sources

CD28-deficient mice are vulnerable to mouse papillomavirus MmuPV1 infection of the skin and mucosae. [PDF]

PLoS Pathog
CD28 is a co-stimulatory molecule expressed on the surface of T cells. To date, three individuals with germline CD28 deficiency have been reported to develop recalcitrant, HPV-driven warts: one exhibited persistent lesions, another experienced disease resolution, and the third developed a chronic “tree-man” phenotype.
Brendle S, Li J, Lu S, Schell TD, Kozak M, Walter V, Shearer D, Place J, Balogh K, Casanova JL, Christensen N, Burgener AD, Murooka TT, Zhu Y, Béziat V, Hu J.   +15 more
europepmc   +3 more sources

MmuPV1 E7 promotes phenotypes associated with “high-risk” HPV infection in mouse keratinocytes [PDF]

Journal of Virology
The E7 oncoprotein of mouse papillomavirus (MmuPV1) plays a pivotal role in both viral infection and cancer development. While earlier studies have identified key cellular targets of MmuPV1 E7, such as pRB and PTPN14, the broader impact of MmuPV1 E7 on ...
Kayla R. Duxbury, Liyan Zhang, Laura K. Muelhbauer, Mitchell Hayes, Joshua J. Coon, Megha Padi, James C. Romero-Masters   +6 more
doaj   +2 more sources

Deficiency in <i>Ever2</i> does not increase susceptibility of mice to pathogenesis by the mouse papillomavirus, MmuPV1. [PDF]

J Virol
ABSTRACT Epidermodysplasia verruciformis (EV) is a rare genetic skin disorder that is characterized by the development of papillomavirus-induced skin lesions that can progress to squamous cell carcinoma (SCC).
Torres AD, King RE, Uberoi A, Buehler D, Yoshida S, Ward-Shaw E, Lambert PF.   +6 more
europepmc   +3 more sources

Passive Immunization with a Single Monoclonal Neutralizing Antibody Protects against Cutaneous and Mucosal Mouse Papillomavirus Infections [PDF]

Journal of Virology, 2022
Jiafen Hu, Karla K Balogh, Sarah A Brendle   +2 more
exaly   +2 more sources

Molecularly Cloned Bovine Papillomavirus DNA Transforms Mouse Fibroblasts in Vitro [PDF]

Journal of General Virology, 1983
NIH 3T3 mouse fibroblasts were transformed in vitro by transfection with viral DNA from bovine papillomavirus (BPV) types 4, 2 and 1. The viral DNAs were molecularly cloned in pAT153 to construct pBV4, a recombinant plasmid containing the whole genome of BPV4, pBV2 containing the entire genome of BPV2, and pBV1-D1 which contains the 69% transforming ...
M S, Campo, D A, Spandidos
openaire   +4 more sources

Retinoic acid metabolism proteins are altered in trichoblastomas induced by mouse papillomavirus 1 [PDF]

Experimental and Molecular Pathology, 2015
Skin cancer burden is significant as treatment costs have skyrocketed to $8.1 million annually and some forms metastasize, such as cutaneous squamous cell carcinoma (cSCC) and melanoma. cSCC is caused by altered growth factor signaling induced by chemical carcinogens, ultraviolet light (UV) exposure, and infections with papillomaviruses (PVs).
Everts, Helen B, Suo, Liye, Ghim, Shinge, Bennett Jenson, A, Sundberg, John P   +4 more
openaire   +4 more sources

Identification and Characterization of MmuPV1 Causing Papillomatosis Outbreak in an Animal Research Facility [PDF]

Viruses
Mouse papillomavirus (MmuPV1) is the first papillomavirus known to infect laboratory mice, making it an irreplaceable tool for research on papillomaviruses. Despite wide use, standardized techniques for conducting MmuPV1 animal research are lacking.
Vladimir Majerciak, Kristin E. Killoran, Lulu Yu, Deanna Gotte, Elijah Edmondson, Matthew W. Breed, Renee E. King, Melody E. Roelke-Parker, Paul F. Lambert, Joshua A. Kramer, Zhi-Ming Zheng   +10 more
doaj   +2 more sources