Results 11 to 20 of about 38,676 (197)

The full transcription map of mouse papillomavirus type 1 (MmuPV1) in mouse wart tissues. [PDF]

PLoS Pathogens, 2017
Mouse papillomavirus type 1 (MmuPV1) provides, for the first time, the opportunity to study infection and pathogenesis of papillomaviruses in the context of laboratory mice.
Xiang-Yang Xue, Vladimir Majerciak, Aayushi Uberoi, Bong-Hyun Kim, Deanna Gotte, Xiongfong Chen, Maggie Cam, Paul F Lambert, Zhi-Ming Zheng   +8 more
doaj   +5 more sources

Monitoring mouse papillomavirus-associated cancer development using longitudinal Pap smear screening [PDF]

mBio
A substantial percentage of the population remains at risk for cervical cancer due to pre-existing human papillomavirus (HPV) infections, despite prophylactic vaccines. Early diagnosis and treatment are crucial for better disease outcomes.
Hannah M. Atkins, Aysegul Aksakal Uslu, Jingwei J. Li, Debra A. Shearer, Sarah A. Brendle, Chen Han, Michael Kozak, Paul Lopez, Deesha Nayar, Karla K. Balogh, Catherine Abendroth, Jean Copper, Keith C. Cheng, Neil D. Christensen, Yusheng Zhu, Stefanie Avril, Adam D. Burgener, Thomas T. Murooka, Jiafen Hu   +18 more
doaj   +4 more sources

Development of an in vivo infection model to study Mouse papillomavirus-1 (MmuPV1) [PDF]

Journal of Virological Methods, 2018
Preclinical model systems to study multiple features of the papillomavirus life cycle are extremely valuable tools to aid our understanding of Human Papillomavirus (HPV) biology, disease progression and treatments. Mouse papillomavirus (MmuPV1) is the first ever rodent papillomavirus that can infect the laboratory strain of mice and was discovered ...
Aayushi Uberoi, Paul F Lambert
exaly   +5 more sources

Vaccination with a Human Papillomavirus L2 Multimer Provides Broad Protection against 17 Human Papillomavirus Types in the Mouse Cervicovaginal Challenge Model

Vaccines
Human papillomavirus (HPV) is a prevalent cause of mucosal and cutaneous infections and underlying conditions ranging from benign warts to anogenital and oropharyngeal cancers affecting both males and females, notably cervical cancer.
Zhenwei Han, Shen Wang, Ting Mu, Ping Zhao, Lingli Song, Ying Zhang, Jin Zhao, Wen Yin, Yue Wu, Huan Wang, Bo Gong, Min Ji, Richard B. S. Roden, Yanping Yang, Michel Klein, Ke Wu   +15 more
doaj   +4 more sources

Efficacy of Topically Administered Dihydroartemisinin in Treating Papillomavirus-Induced Anogenital Dysplasia in Preclinical Mouse Models

Viruses, 2022
The artemisinin family of compounds is cytopathic in certain cancer cell lines that are positive for human papillomaviruses (HPV) and can potentially drive the regression of dysplastic lesions. We evaluated the efficacy of topical dihydroartemisinin (DHA)
Laura C. Gunder, Simon Blaine-Sauer, Hillary R. Johnson, Myeong-Kyun Shin, Andrew S. Auyeung, Wei Zhang, Glen E. Leverson, Ella T. Ward-Shaw, Renee E. King, Stephanie M. McGregor, Kristina A. Matkowskyj, Paul F. Lambert, Evie H. Carchman   +12 more
doaj   +2 more sources

mSphere of Influence: MmuPV1—a dual tropic papillomavirus, red herring, or novel insight into HPV pathogenesis

mSphere
James Romero-Masters works in the field of tumor virology, focusing on the role of the human papillomavirus oncogenes in pathogenesis. In this mSphere of Influence article, they reflect on how the article “Mouse papillomavirus infection persists in ...
James Romero-Masters
doaj   +2 more sources

Stress keratin 17 enhances papillomavirus infection-induced disease by downregulating T cell recruitment.

PLoS Pathogens, 2020
High-risk human papillomaviruses (HPVs) cause 5% of human cancers. Despite the availability of HPV vaccines, there remains a strong urgency to find ways to treat persistent HPV infections, as current HPV vaccines are not therapeutic for individuals ...
Wei Wang, Aayushi Uberoi, Megan Spurgeon, Ellery Gronski, Vladimir Majerciak, Alexei Lobanov, Mitchell Hayes, Amanda Loke, Zhi-Ming Zheng, Paul F Lambert   +9 more
doaj   +2 more sources

The vaginal microbiome, papillomavirus infection, and cervical cancer: established associations in search of model systems and mechanistic answers [PDF]

mBio
High-risk human papillomavirus (HPV) infection is the causative factor for approximately 5% of all human cancers and the leading cause of cervical cancer. High-risk HPV-associated cervical cancer still claims more than 340,000 women’s lives globally each
Gianna V. Passarelli, Sonia N. Whang, Nicole M. Gilbert, Jiafen Hu   +3 more
doaj   +2 more sources

MmuPV1 E7 promotes phenotypes associated with “high-risk” HPV infection in mouse keratinocytes [PDF]

Journal of Virology
The E7 oncoprotein of mouse papillomavirus (MmuPV1) plays a pivotal role in both viral infection and cancer development. While earlier studies have identified key cellular targets of MmuPV1 E7, such as pRB and PTPN14, the broader impact of MmuPV1 E7 on ...
Kayla R. Duxbury, Liyan Zhang, Laura K. Muelhbauer, Mitchell Hayes, Joshua J. Coon, Megha Padi, James C. Romero-Masters   +6 more
doaj   +2 more sources

Passive Immunization with a Single Monoclonal Neutralizing Antibody Protects against Cutaneous and Mucosal Mouse Papillomavirus Infections [PDF]

Journal of Virology, 2022
Sarah A Brendle, Karla K Balogh, Jake Debroff   +2 more
exaly   +2 more sources