Self-Assembly of Antigenic Peptide Nanofibrils Templates the Growth of Silica Nanoparticles for Nanovaccines. [PDF]
Adv Sci (Weinh)Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Yang X +6 more
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The vaginal microbiome, papillomavirus infection, and cervical cancer: established associations in search of model systems and mechanistic answers [PDF]
mBioHigh-risk human papillomavirus (HPV) infection is the causative factor for approximately 5% of all human cancers and the leading cause of cervical cancer. High-risk HPV-associated cervical cancer still claims more than 340,000 women’s lives globally each
Gianna V. Passarelli +3 more
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A mouse model of HPV-associated cervicovaginal carcinosarcoma with comparative analysis to human clinical cases [PDF]
Cell & BioscienceBackground Carcinosarcomas of the gynecologic tract, previously referred to as malignant mixed müllerian/mesodermal tumor, are devastating malignancies that remain poorly studied due to their rarity and the lack of relevant model systems.
Jason Murray +4 more
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Development of an in vivo infection model to study Mouse papillomavirus-1 (MmuPV1) [PDF]
Journal of Virological Methods, 2018 Paul Lambert, Aayushi Uberoi
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JID Innovations, 2023 Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer, with increased incidence in immunosuppressed patients. β-Human papillomavirus has been proposed as a contributor to cSCC risk partly on the basis of increased β-human ...
Luke H. Johnson +5 more
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Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model
Pathogens, 2023 Human papillomavirus (HPV)-induced oropharyngeal cancer now exceeds HPV-induced cervical cancer, with a noticeable sex bias. Although it is well established that women have a more proficient immune system, it remains unclear whether immune control of ...
Sarah A. Brendle +10 more
doaj +1 more source
Cryo EM Analysis Reveals Inherent Flexibility of Authentic Murine Papillomavirus Capsids
Viruses, 2021 Human papillomavirus (HPV) is a significant health burden and leading cause of virus-induced cancers. However, studies have been hampered due to restricted tropism that makes production and purification of high titer virus problematic.
Samantha R. Hartmann +6 more
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Viruses, 2022 Murine papillomavirus, MmuPV1, causes natural infections in laboratory mice that can progress to squamous cell carcinoma (SCC) making it a useful preclinical model to study the role of papillomaviruses in cancer.
Ruben Moreno +2 more
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A novel lineage-tracing mouse model for studying early MmuPV1 infections
eLife, 2022 Human papillomaviruses are DNA viruses that ubiquitously infect humans and have been associated with hyperproliferative lesions. The recently discovered mouse specific papillomavirus (MmuPV1) provides the opportunity to study papillomavirus infections in
Vural Yilmaz +4 more
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Mouse papillomavirus MmuPV1 infects oral mucosa and preferentially targets the base of the tongue [PDF]
Virology, 2016 Jiafen Hu +2 more
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