Results 11 to 20 of about 38,779 (193)

A Mouse Model of Oropharyngeal Papillomavirus-Induced Neoplasia Using Novel Tools for Infection and Nasal Anesthesia [PDF]

Viruses, 2020
Human head and neck cancers that develop from the squamous cells of the oropharynx (Oropharyngeal Squamous Cell Carcinomas or OPSCC) are commonly associated with the papillomavirus infection.
Andrea Bilger, Renee E. King, Josh P. Schroeder, Jared T. Piette, Louis A. Hinshaw, Andrew D. Kurth, Ronnie W. AlRamahi, Matthew V. Barthel, Ella T. Ward-Shaw, Darya Buehler, Kristyn S. Masters, Susan L. Thibeault, Paul F. Lambert   +12 more
doaj   +4 more sources

Monitoring mouse papillomavirus-associated cancer development using longitudinal Pap smear screening [PDF]

mBio
A substantial percentage of the population remains at risk for cervical cancer due to pre-existing human papillomavirus (HPV) infections, despite prophylactic vaccines. Early diagnosis and treatment are crucial for better disease outcomes.
Hannah M. Atkins, Aysegul Aksakal Uslu, Jingwei J. Li, Debra A. Shearer, Sarah A. Brendle, Chen Han, Michael Kozak, Paul Lopez, Deesha Nayar, Karla K. Balogh, Catherine Abendroth, Jean Copper, Keith C. Cheng, Neil D. Christensen, Yusheng Zhu, Stefanie Avril, Adam D. Burgener, Thomas T. Murooka, Jiafen Hu   +18 more
doaj   +4 more sources

Vaccination with a Human Papillomavirus L2 Multimer Provides Broad Protection against 17 Human Papillomavirus Types in the Mouse Cervicovaginal Challenge Model [PDF]

Vaccines
Human papillomavirus (HPV) is a prevalent cause of mucosal and cutaneous infections and underlying conditions ranging from benign warts to anogenital and oropharyngeal cancers affecting both males and females, notably cervical cancer.
Zhenwei Han, Shen Wang, Ting Mu, Ping Zhao, Lingli Song, Ying Zhang, Jin Zhao, Wen Yin, Yue Wu, Huan Wang, Bo Gong, Min Ji, Richard B. S. Roden, Yanping Yang, Michel Klein, Ke Wu   +15 more
doaj   +4 more sources

Mouse Papillomavirus Outbreak in a Research Facility. [PDF]

J Am Assoc Lab Anim Sci
The use of mouse papillomavirus (MmuPV1) to study infections, disease outcomes, and vaccine strategies in mice has greatly enhanced our understanding of human papillomavirus. However, as with other species-specific infectious agents used as models for human disease, such studies may pose a risk to facilities that house large numbers of the model agent ...
Killoran KE, Breed MW, Roelke-Parker ME, Carney S, Edmondson E, Thompson CD, Schiller JT, Henderson K, Woods CL, Albers TM, Starost MF, Kramer JA.   +11 more
europepmc   +4 more sources

Expanded Basal Compartment and Disrupted Barrier in Vocal Fold Epithelium Infected with Mouse Papillomavirus MmuPV1 [PDF]

Viruses, 2022
Laryngeal infection with low-risk human papillomaviruses can cause recurrent respiratory papillomatosis (RRP), a disease with severe effects on vocal fold epithelium resulting in impaired voice function and communication. RRP research has been stymied by
Renee E. King, Ella T. Ward-Shaw, Rong Hu, Paul F. Lambert, Susan L. Thibeault   +4 more
doaj   +2 more sources

Mouse papillomavirus infections spread to cutaneous sites with progression to malignancy. [PDF]

J Gen Virol, 2017
We report secondary cutaneous infections in the mouse papillomavirus (MmuPV1)/mouse model. Our previous study demonstrated that cutaneous MmuPV1 infection could spread to mucosal sites. Recently, we observed that mucosal infections could also spread to various cutaneous sites including the back, tail, muzzle and mammary tissues.
Cladel NM, Budgeon LR, Cooper TK, Balogh KK, Christensen ND, Myers R, Majerciak V, Gotte D, Zheng ZM, Hu J.   +9 more
europepmc   +3 more sources

EXPRESSION OF E8^E2 IS REQUIRED FOR WART FORMATION BY MOUSE PAPILLOMAVIRUS 1 IN VIVO. [PDF]

J Virol, 2021
HPV encodes an E8^E2 protein which acts as repressors of viral gene expression and genome replication. In cultured normal keratinocytes, E8^E2 is essential for long-term episomal maintenance of HPV 31 (HPV31) genomes, but not for that of HPV16.
Stubenrauch F, Straub E, Klein K, Kramer D, Iftner T, Wong M, Roden RBS.   +6 more
europepmc   +4 more sources

Efficacy of Topically Administered Dihydroartemisinin in Treating Papillomavirus-Induced Anogenital Dysplasia in Preclinical Mouse Models [PDF]

Viruses, 2022
The artemisinin family of compounds is cytopathic in certain cancer cell lines that are positive for human papillomaviruses (HPV) and can potentially drive the regression of dysplastic lesions. We evaluated the efficacy of topical dihydroartemisinin (DHA)
Laura C. Gunder, Simon Blaine-Sauer, Hillary R. Johnson, Myeong-Kyun Shin, Andrew S. Auyeung, Wei Zhang, Glen E. Leverson, Ella T. Ward-Shaw, Renee E. King, Stephanie M. McGregor, Kristina A. Matkowskyj, Paul F. Lambert, Evie H. Carchman   +12 more
doaj   +2 more sources

Tracking vaginal, anal and oral infection in a mouse papillomavirus infection model. [PDF]

J Gen Virol, 2015
Noninvasive and practical techniques to longitudinally track viral infection are sought after in clinical practice. We report a proof-of-principle study to monitor the viral DNA copy number using a newly established mouse papillomavirus (MmuPV1) mucosal infection model.
Hu J, Budgeon LR, Cladel NM, Balogh K, Myers R, Cooper TK, Christensen ND.   +6 more
europepmc   +3 more sources

mSphere of Influence: MmuPV1—a dual tropic papillomavirus, red herring, or novel insight into HPV pathogenesis [PDF]

mSphere
James Romero-Masters works in the field of tumor virology, focusing on the role of the human papillomavirus oncogenes in pathogenesis. In this mSphere of Influence article, they reflect on how the article “Mouse papillomavirus infection persists in ...
James Romero-Masters
doaj   +2 more sources