Results 41 to 50 of about 38,676 (197)

Down-regulation of MHC class I is a property common to papillomavirus E5 proteins [PDF]

, 2006
The E5 protein family of papillomaviruses comprises small hydrophobic proteins which are associated with the cell endomembrane compartments. The functions of the E5 proteins, particularly those of HPV, are still far from clear.
Fife, K.H., G.H. Ashrafi, Ashrafi, G, Campo, M, D.R. Brown, Ashrafi, G.H., M.S. Campo, Brown, D.R., Fife, K, Campo, M.S., Brown, D R, K.H. Fife   +11 more
core   +1 more source

HPV-positive murine oral squamous cell carcinoma: development and characterization of a new mouse tumor model for immunological studies

Journal of Translational Medicine, 2023
Background Infection with high-risk human papillomavirus (HPV) strains is one of the risk factors for the development of oral squamous cell carcinoma (OSCC).
Ziva Modic, Maja Cemazar, Bostjan Markelc, Andrej Cör, Gregor Sersa, Simona Kranjc Brezar, Tanja Jesenko   +6 more
doaj   +1 more source

Immunization and immunotherapy for cancers involving infection by a human papillomavirus in a mouse model [PDF]

Proceedings of the National Academy of Sciences, 2002
We describe a protocol for generating a potent cellular immune response against viral-infected cells, and demonstrate its efficacy and safety in a mouse model of human cancer associated with infection by a human papillomavirus (HPV). In the mouse model, the mouse tumor TC-1, which expresses the E7 oncoprotein from HPV-16, is used as a surrogate for ...
Jin, Li, Ying, Sun, Alan, Garen
openaire   +2 more sources

Deficiency in <i>Ever2</i> does not increase susceptibility of mice to pathogenesis by the mouse papillomavirus, MmuPV1. [PDF]

J Virol
ABSTRACT Epidermodysplasia verruciformis (EV) is a rare genetic skin disorder that is characterized by the development of papillomavirus-induced skin lesions that can progress to squamous cell carcinoma (SCC).
Torres AD, King RE, Uberoi A, Buehler D, Yoshida S, Ward-Shaw E, Lambert PF.   +6 more
europepmc   +3 more sources

Downregulation of major histocompatibility complex class I in bovine papillomas [PDF]

, 2004
Bovine papillomavirus (BPV) induces papillomas in cattle; in the great majority of cases, these regress due to the host immune response, but they can persist and progress to malignancy.
Marchetti, B, Araibi, E.H., Ashrafi, G.H., Campo, M.S., Marchetti, B., Araibi, E. H.   +5 more
core   +1 more source

Synergistic Interaction Between HPV-16 E7 Oncoprotein and Severe Vitamin A Deficiency in Regulating Adaptive Immunity in a Preclinical Cervical Cancer Model. [PDF]

J Med Virol
ABSTRACT Persistent infection with High‐Risk Human Papillomavirus (HR‐HPV), particularly HPV‐16, is the main driver of cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). However, HR‐HPV infection alone is insufficient for malignant progression and nutritional cofactors such as Vitamin A deficiency, may influence cervical neoplasia ...
Chávez-Ríos A, López-Ruiz C, García-Aguirre IA, Ocadiz-Delgado R, Garcia-Sierra F, Hernández-Pando R, Lizcano-Meneses S, Gariglio P.   +7 more
europepmc   +2 more sources

Human papillomavirus 16 L2 inhibits the transcriptional activation function, but not the DNA replication function, of HPV-16 E2 [PDF]

, 2005
In this study we analysed the outcome of the interaction between HPV-16 L2 and E2 on the transactivation and DNA replication functions of E2. When E2 was expressed on its own, it transactivated a number of E2-responsive promoters but co-expression of L2 ...
Morgan, I.M., Cordano, P., Taylor, E.R., Everett, R., R. Everett, A. Okoye, M.S. Campo, P. Cordano, E.R. Taylor, Campo, M.S., I.M. Morgan, Okoye, A.   +11 more
core   +1 more source

Hierarchy of polyadenylation site usage by bovine papillomavirus in transformed mouse cells [PDF]

Journal of Virology, 1993
The great majority of viral mRNAs in mouse C127 cells transformed by bovine papillomavirus type 1 (BPV) have a common 3' end at the early polyadenylation site which is 23 nucleotides (nt) downstream of a canonical poly(A) consensus signal. Twenty percent of BPV mRNA from productively infected cells bypasses the early polyadenylation site and uses the ...
E M, Andrews, D, DiMaio
openaire   +2 more sources

Similarities and differences between the E5 oncoproteins of bovine papillomaviruses type 1 and type 4: Cytoskeleton, motility and invasiveness in E5-transformed bovine and mouse cells [PDF]

, 2006
Bovine papillomaviruses (BPVs) are oncogenic viruses. In cattle, BPV-1/2 is associated with urinary bladder cancer and BPV-4 with upper GI tract cancer. BPV E5 is a small hydrophobic protein localised in the endoplasmic reticulum (ER) and Golgi apparatus
Ullah, R., Campo, M, Ozanne, B, McGarry, L, Marchetti, B, Ashrafi, G, Ashrafi, G.H., Ullah, R, McGarry, L., Tsirimonaki, E., Campo, M.S., Marchetti, B., Ozanne, B.W., Tsirimonaki, E   +13 more
core   +1 more source

MmuPV1 E6 induces cell proliferation and other hallmarks of cancer

mBio, 2023
The E6 protein encoded by the murine papillomavirus (MmuPV1) is essential for MmuPV1-induced skin disease. Our previous work has identified a number of cellular interacting partners of MmuPV1 E6 and E7 through affinity purification/mass spectrometry ...
James C. Romero-Masters, Laura K. Muehlbauer, Mitchell Hayes, Miranda Grace, Evgenia Shishkova, Joshua J. Coon, Karl Munger, Paul F. Lambert   +7 more
doaj   +1 more source