Results 61 to 70 of about 38,676 (197)

Key aspects of papillomavirus infection influence the host cervicovaginal microbiome in a preclinical murine papillomavirus (MmuPV1) infection model

mBio
Human papillomaviruses (HPVs) are the most common sexually transmitted infection in the United States and are a major etiological agent of cancers in the anogenital tract and oral cavity.
Megan E. Spurgeon, Elizabeth C. Townsend, Simon Blaine-Sauer, Stephanie M. McGregor, Mark Horswill, Johan A. den Boon, Paul Ahlquist, Lindsay Kalan, Paul F. Lambert   +8 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The rabbit as an animal model to study innate immunity genes: Is it better than mice?

Frontiers in Immunology, 2022
The European rabbit (Oryctolagus cuniculus) was the first animal model used to understand human diseases like rabies and syphilis. Nowadays, the rabbit is still used to study several human infectious diseases like syphilis, HIV and papillomavirus ...
João Soares, João Soares, Ana Pinheiro, Ana Pinheiro, Pedro José Esteves, Pedro José Esteves, Pedro José Esteves, Pedro José Esteves   +7 more
doaj   +1 more source

CCCTC-binding factor recruitment to the early region of the human papillomavirus type 18 genome regulates viral oncogene expression

, 2015
C.P. was supported by a Ph.D. studentshipfunded by the University of St. Andrews, School of Medicine. I.P. is supported by a Cancer Research UK (CRUK) Ph.D. studentship awarded to J.L.P. and S.R. I.G. and N.C.
Coleman, Nicholas, Roberts, David, Groves, Ian, Powis, Simon J, Roberts, Sally, Roberts, David C, Pentland, Ieisha, Parish, Joanna; id_orcid, Parish, Joanna L, Paris, Christian   +9 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Bovine papillomavirus vector that propagates as a plasmid in both mouse and bacterial cells. [PDF]

Proceedings of the National Academy of Sciences, 1982
We report the construction of a bovine papillomavirus (BPV)-derived recombinant plasmid that propagates as an extrachromosomal element in both mouse and bacterial cells. Plasmids composed of a subgenomic transforming fragment of BPV DNA, a deletion derivative of pBR322, and a 7.6-kilobase fragment of DNA from the human beta-globin gene cluster ...
D, DiMaio, R, Treisman, T, Maniatis
openaire   +2 more sources

The use of a topical protease inhibitor, Saquinavir, to alleviate mouse papillomavirus-mediated anal disease

Virology, 2022
Select protease inhibitors (PI) have been found to be effective in decreasing human papillomavirus oncoprotein expression. This study evaluated whether the topical PI, Saquinavir (SQV), promotes viral clearance in an infectious mouse model with Mus musculus papillomavirus 1 (MmuPV1).
Laura C, Gunder, Hillary R, Johnson, Heather A, Green, Andrea, Bilger, Tyra H, Moyer, Wei, Zhang, Marissa R, Ziolkowski, Payton A, Bertrang, Evie H, Carchman   +8 more
openaire   +2 more sources

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Propagation of Human Papillomavirus Type 59 in the Athymic Mouse Xenograft System

Intervirology, 2000
Studies of human papillomavirus (HPV) infection are hampered by the lack of an adequate culture system. The athymic mouse xenograft system permits propagation of HPV, but only a few HPV types have been grown in this manner. To produce an oncogenic type for studies of HPV pathogenesis, a condylomata acuminata lesion from an immunosuppressed patient was ...
J T, Bryan, J, Tekchandani, J M, Schroeder, D R, Brown   +3 more
openaire   +2 more sources

Design and Immunological Validation of Macaca fascicularis Papillomavirus Type 3 Based Vaccine Candidates in Outbred Mice: Basis for Future Testing of a Therapeutic Papillomavirus Vaccine in NHPs

Frontiers in Immunology, 2021
Persistent human papillomavirus (HPV) infections are causative for cervical neoplasia and carcinomas. Despite the availability of prophylactic vaccines, morbidity and mortality induced by HPV are still too high.
Patrick Neckermann, Ditte Rahbaek Boilesen, Ditte Rahbaek Boilesen, Torsten Willert, Cordula Pertl, Silke Schrödel, Christian Thirion, Benedikt Asbach, Peter Johannes Holst, Peter Johannes Holst, Ralf Wagner, Ralf Wagner   +11 more
doaj   +1 more source