Results 71 to 80 of about 38,676 (197)

Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers

Advanced Science, EarlyView.
This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu, Yujia Zhou, Zihan Zhang, Rong Ma, Luyi Ruan, Liqing Miao, Boxin Zhang, Huihui Ji, Tianfeng Chen, Xueqiong Zhu   +9 more
wiley   +1 more source

Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models

Emerging Microbes and Infections, 2019
Human papillomaviruses (HPV) contribute to most cervical cancers and are considered to be sexually transmitted. However, papillomaviruses are often found in cancers of internal organs, including the stomach, raising the question as to how the viruses ...
Nancy M. Cladel, Pengfei Jiang, Jingwei J. Li, Xuwen Peng, Timothy K. Cooper, Vladimir Majerciak, Karla K. Balogh, Thomas J. Meyer, Sarah A. Brendle, Lynn R. Budgeon, Debra A. Shearer, Regina Munden, Maggie Cam, Raghavan Vallur, Neil D. Christensen, Zhi-Ming Zheng, Jiafen Hu   +16 more
doaj   +1 more source

AKT1 loss correlates with episomal HPV16 in vulval intraepithelial neoplasia. [PDF]

, 2012
Anogenital malignancy has a significant association with high-risk mucosal alpha-human papillomaviruses (alpha-PV), particularly HPV 16 and 18 whereas extragenital SCC has been linked to the presence of cutaneous beta and gamma-HPV types. Vulval skin may
Harwood Catherine A., Carolyn R Byrne, Karin J Purdie, Byrne, CR, Ekeowa-Anderson, AL, Purdie, Karin J, Jeffrey M. Arbeit (159402), Karin J. Purdie (159384), Jeffrey M Arbeit, O'Shaughnessy Ryan F. L., Byrne Carolyn R., Ekeowa-Anderson Arucha L., Gibbon, K, Ekeowa-Anderson, Arucha L, Byrne, Carolyn R, O'Shaughnessy, RFL, Ryan F L O'Shaughnessy, O'Shaughnessy, RF, Harwood, CA, Purdie Karin J., Arbeit, Jeffrey M, Arucha L. Ekeowa-Anderson (159376), Harwood, Catherine A, Karen Gibbon, Arbeit Jeffrey M., Arucha L Ekeowa-Anderson, Gibbon, Karen, Karen Gibbon (159391), Catherine A. Harwood (159410), Purdie, KJ, Ryan F. L. O'Shaughnessy (159418), Catherine A Harwood, Arbeit, JM, Gibbon Karen, O\u27Shaughnessy, Ryan F. L., Carolyn R. Byrne (159397)   +35 more
core   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Requirement for Estrogen Receptor α in a Mouse Model for Human Papillomavirus–Associated Cervical Cancer [PDF]

Cancer Research, 2008
Abstract The majority of human cervical cancers are associated with the high-risk human papillomaviruses (HPV), which encode the potent E6 and E7 oncogenes. On prolonged treatment with physiologic levels of exogenous estrogen, K14E7 transgenic mice expressing HPV-16 E7 oncoprotein in their squamous epithelia succumb to uterine cervical ...
Sang-Hyuk, Chung, Kerri, Wiedmeyer, Anny, Shai, Kenneth S, Korach, Paul F, Lambert   +4 more
openaire   +2 more sources

Estradiol, Progesterone, and Transforming Growth Factor α Regulate Insulin-Like Growth Factor Binding Protein-3 (IGFBP3) Expression in Mouse Endometrial Cells [PDF]

, 2009
Insulin-like growth factor 1 (IGF1) Is Involved in the proliferation of mouse and rat endometrial cells in a paracrine or autocrine manner. Insulin-like growth factor binding protein-3 (IGFBP3) modulates actions of IGFs directly or indirectly.
Takahashi, Sumio, Takeuchi, Sakae, Kanayama, Munetoshi, Maekawa, Tetsuya   +3 more
core   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

Advanced NanoBiomed Research, EarlyView.
Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira, Patrick Opdensteinen, Andrea Simms, Seongwon Jung, Giuliana P. Mognol, Hui Chen, Judith A. Varner, Nicole F. Steinmetz   +7 more
wiley   +1 more source

Human Papillomavirus: Update in Bridging Basic Science to Clinical and Public Health Innovations. [PDF]

Health Sci Rep
ABSTRACT Human papillomavirus (HPV), a non‐enveloped, double‐strand DNA viral pathogen, is intricately linked with the onset of various cancers, including cervical cancer and head and neck cancers. The present paper delves into HPV's ancient recognition and significant milestones such as the discovery of its role in oncogenesis and the development of ...
Beygnejad F, Eslami N, Nejad KG, Kermanshahi AZ, Baghi HB.   +4 more
europepmc   +2 more sources

HPV38 impairs UV-induced transcriptional activation of the IL-18 pro-inflammatory cytokine

mSphere, 2023
Increasing evidence suggests that the beta genus of human papillomavirus (β-HPV) cooperates with ultraviolet B (UVB) radiation in inducing non-melanoma skin cancer (NMSC).
Maria Grazia Ceraolo, Maria Carmen Romero-Medina, Simone Gobbato, Giusi Melita, Hanna Krynska, Cecilia Sirand, Purnima Gupta, Daniele Viarisio, Alexis Robitaille, Jacqueline Marvel, Massimo Tommasino, Assunta Venuti, Tarik Gheit   +12 more
doaj   +1 more source