Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model [PDF]
Pathogens, 2023 Human papillomavirus (HPV)-induced oropharyngeal cancer now exceeds HPV-induced cervical cancer, with a noticeable sex bias. Although it is well established that women have a more proficient immune system, it remains unclear whether immune control of ...
Jiafen Hu +2 more
exaly +7 more sources
MmuPV1 E7’s interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease [PDF]
PLoS Pathogens, 2023 Human papillomaviruses (HPVs) contribute to approximately 5% of all human cancers. Species-specific barriers limit the ability to study HPV pathogenesis in animal models.
Miranda Grace +2 more
exaly +9 more sources
Expanded Basal Compartment and Disrupted Barrier in Vocal Fold Epithelium Infected with Mouse Papillomavirus MmuPV1 [PDF]
Viruses, 2022 Laryngeal infection with low-risk human papillomaviruses can cause recurrent respiratory papillomatosis (RRP), a disease with severe effects on vocal fold epithelium resulting in impaired voice function and communication. RRP research has been stymied by
Renee E KING +2 more
exaly +7 more sources
Molecular Mechanisms of MmuPV1 E6 and E7 and Implications for Human Disease [PDF]
Viruses, 2022 Human papillomaviruses (HPVs) cause a substantial amount of human disease from benign disease such as warts to malignant cancers including cervical carcinoma, head and neck cancer, and non-melanoma skin cancer.
James C Romero-Masters +2 more
exaly +7 more sources
MmuPV1-Induced Cutaneous Squamous Cell Carcinoma Arises Preferentially from Lgr5+ Epithelial Progenitor Cells [PDF]
Viruses, 2022 Murine papillomavirus, MmuPV1, causes natural infections in laboratory mice that can progress to squamous cell carcinoma (SCC) making it a useful preclinical model to study the role of papillomaviruses in cancer.
Darya Buehler +2 more
exaly +7 more sources
A Conserved Di-Lysine Motif in the E2 Transactivation Domain Regulates MmuPV1 Replication and Disease Progression [PDF]
PathogensThe papillomavirus E2 protein regulates the transcription, replication, and segregation of viral episomes within the host cell. A multitude of post-translational modifications have been identified which control E2 functions.
Elliot J Androphy
exaly +8 more sources
MmuPV1 E6 induces cell proliferation and other hallmarks of cancer [PDF]
MBio, 2023 The E6 protein encoded by the murine papillomavirus (MmuPV1) is essential for MmuPV1-induced skin disease. Our previous work has identified a number of cellular interacting partners of MmuPV1 E6 and E7 through affinity purification/mass spectrometry ...
James C Romero-Masters +2 more
exaly +6 more sources
MmuPV1 E7 promotes phenotypes associated with “high-risk” HPV infection in mouse keratinocytes [PDF]
Journal of VirologyThe E7 oncoprotein of mouse papillomavirus (MmuPV1) plays a pivotal role in both viral infection and cancer development. While earlier studies have identified key cellular targets of MmuPV1 E7, such as pRB and PTPN14, the broader impact of MmuPV1 E7 on ...
Mitchell Hayes, James C Romero-Masters
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A conserved cysteine in the DNA-binding domain of MmuPV1 E2 is required for replication in vivo [PDF]
Journal of VirologyThe papillomavirus (PV) E2 protein is highly conserved, consisting of an N-terminal transactivation domain linked to a C-terminal DNA binding and dimerization domain (DBD) by a flexible hinge region.
Elliot J Androphy
exaly +6 more sources
mSphere of Influence: MmuPV1—a dual tropic papillomavirus, red herring, or novel insight into HPV pathogenesis [PDF]
MSphereJames Romero-Masters works in the field of tumor virology, focusing on the role of the human papillomavirus oncogenes in pathogenesis. In this mSphere of Influence article, they reflect on how the article “Mouse papillomavirus infection persists in ...
James C Romero-Masters
exaly +7 more sources