Identification and Characterization of MmuPV1 Causing Papillomatosis Outbreak in an Animal Research Facility [PDF]
VirusesMouse papillomavirus (MmuPV1) is the first papillomavirus known to infect laboratory mice, making it an irreplaceable tool for research on papillomaviruses. Despite wide use, standardized techniques for conducting MmuPV1 animal research are lacking.
Zhi-Ming Zheng +2 more
exaly +6 more sources
MmuPV1 E7 promotes phenotypes associated with “high-risk” HPV infection in mouse keratinocytes [PDF]
Journal of VirologyThe E7 oncoprotein of mouse papillomavirus (MmuPV1) plays a pivotal role in both viral infection and cancer development. While earlier studies have identified key cellular targets of MmuPV1 E7, such as pRB and PTPN14, the broader impact of MmuPV1 E7 on ...
Jame Romero-Masters
exaly +6 more sources
MmuPV1 E7’s interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease [PDF]
PLoS Pathogens, 2023 Human papillomaviruses (HPVs) contribute to approximately 5% of all human cancers. Species-specific barriers limit the ability to study HPV pathogenesis in animal models.
Paul Lambert +2 more
exaly +8 more sources
E2 Tyrosine 102 Regulates MmuPV1 Pathogenesis In Vivo [PDF]
PathogensThe papillomavirus (PV) life cycle is strictly controlled and can be divided into the following three distinct stages: initial infection, maintenance, and amplification.
Neil Christensen +2 more
exaly +7 more sources
Molecular Mechanisms of MmuPV1 E6 and E7 and Implications for Human Disease [PDF]
Viruses, 2022 Human papillomaviruses (HPVs) cause a substantial amount of human disease from benign disease such as warts to malignant cancers including cervical carcinoma, head and neck cancer, and non-melanoma skin cancer.
Jame Romero-Masters +2 more
exaly +6 more sources
A conserved cysteine in the DNA-binding domain of MmuPV1 E2 is required for replication in vivo [PDF]
Journal of VirologyThe papillomavirus (PV) E2 protein is highly conserved, consisting of an N-terminal transactivation domain linked to a C-terminal DNA binding and dimerization domain (DBD) by a flexible hinge region.
Elliot Androphy
exaly +6 more sources
A Conserved Di-Lysine Motif in the E2 Transactivation Domain Regulates MmuPV1 Replication and Disease Progression [PDF]
PathogensThe papillomavirus E2 protein regulates the transcription, replication, and segregation of viral episomes within the host cell. A multitude of post-translational modifications have been identified which control E2 functions.
Elliot Androphy
exaly +6 more sources
MmuPV1 E6 induces cell proliferation and other hallmarks of cancer [PDF]
mBio, 2023 The E6 protein encoded by the murine papillomavirus (MmuPV1) is essential for MmuPV1-induced skin disease. Our previous work has identified a number of cellular interacting partners of MmuPV1 E6 and E7 through affinity purification/mass spectrometry ...
James C. Romero-Masters +7 more
doaj +4 more sources
mSphere of Influence: MmuPV1—a dual tropic papillomavirus, red herring, or novel insight into HPV pathogenesis [PDF]
MSphereJames Romero-Masters works in the field of tumor virology, focusing on the role of the human papillomavirus oncogenes in pathogenesis. In this mSphere of Influence article, they reflect on how the article “Mouse papillomavirus infection persists in ...
Jame Romero-Masters
exaly +7 more sources
Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model [PDF]
Pathogens, 2023 Human papillomavirus (HPV)-induced oropharyngeal cancer now exceeds HPV-induced cervical cancer, with a noticeable sex bias. Although it is well established that women have a more proficient immune system, it remains unclear whether immune control of ...
Sarah A. Brendle +10 more
doaj +4 more sources