Results 31 to 40 of about 421 (121)

Increased Susceptibility of WHIM Mice to Papillomavirus-induced Disease is Dependent upon Immune Cell Dysfunction. [PDF]

PLoS Pathogens
Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) syndrome is a rare primary immunodeficiency disease in humans caused by a gain of function in CXCR4, mostly due to inherited heterozygous mutations in CXCR4. One major clinical symptom of
Wei Wang, Ali Pope, Ella Ward-Shaw, Darya Buehler, Francoise Bachelerie, Paul F Lambert   +5 more
doaj   +2 more sources

Isolation and quantification of MmuPV1 virions from papillomas v1

, 2017
In this section we describe our method of isolation and quantification of MmuPV1 virions from papillomas arising in nude mice that can be serially passaged or used to infect other strains of mice.
Paul Lambert, Aayushi Uberoi
core   +2 more sources

Monitoring mouse papillomavirus-associated cancer development using longitudinal Pap smear screening [PDF]

mBio
A substantial percentage of the population remains at risk for cervical cancer due to pre-existing human papillomavirus (HPV) infections, despite prophylactic vaccines. Early diagnosis and treatment are crucial for better disease outcomes.
Hannah M. Atkins, Aysegul Aksakal Uslu, Jingwei J. Li, Debra A. Shearer, Sarah A. Brendle, Chen Han, Michael Kozak, Paul Lopez, Deesha Nayar, Karla K. Balogh, Catherine Abendroth, Jean Copper, Keith C. Cheng, Neil D. Christensen, Yusheng Zhu, Stefanie Avril, Adam D. Burgener, Thomas T. Murooka, Jiafen Hu   +18 more
doaj   +2 more sources

The Mouse Papillomavirus Infection Model

Viruses, 2017
The mouse papillomavirus (MmuPV1) was first reported in 2011 and has since become a powerful research tool. Through collective efforts from different groups, significant progress has been made in the understanding of molecular, virological, and ...
Jiafen Hu, Nancy M. Cladel, Lynn R. Budgeon, Karla K. Balogh, Neil D. Christensen   +4 more
doaj   +2 more sources

Intraperitoneal delivery of cannabidiol (CBD) and Δ9-tetrahydocannabinol (THC) promotes papillomavirus infections in athymic nude mice [PDF]

Tumour Virus Research
We used our mouse papillomavirus (MmuPV1) model to test the hypothesis that two primary psychoactive ingredients of marijuana, Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), promote papillomavirus persistence in the oral mucosa of infected mice. We
Sarah A. Brendle, Jingwei Li, Dongxiao Sun, Junjia Zhu, Angela N. Henderson-Redmond, Daniel J. Morgan, Karla K. Balogh, Danielle Covington, Debra A. Shearer, Jiafen Hu   +9 more
doaj   +2 more sources

Preclinical Models of Laryngeal Papillomavirus Infection: A Scoping Review

The Laryngoscope, Volume 133, Issue 12, Page 3256-3268, December 2023., 2023
HPV can cause highly morbid laryngeal diseases, including benign communication impairment, and cancer. Preclinical models of these diseases are needed to develop effective treatments. This study summarizes all research studies that describe models of laryngeal HPV infection.
Renee E. King, Andrea Bilger, Josef Rademacher, Paul F. Lambert, Susan L. Thibeault   +4 more
wiley   +1 more source

The Mus musculus Papillomavirus Type 1 E7 Protein Binds to the Retinoblastoma Tumor Suppressor: Implications for Viral Pathogenesis

mBio, 2021
The species specificity of papillomaviruses has been a significant roadblock for performing in vivo pathogenesis studies in common model organisms. The Mus musculus papillomavirus type 1 (MmuPV1) causes cutaneous papillomas that can progress to squamous ...
Tao Wei, Miranda Grace, Aayushi Uberoi, James C. Romero-Masters, Denis Lee, Paul F. Lambert, Karl Munger   +6 more
doaj   +1 more source

Recent advances in cutaneous HPV infection

The Journal of Dermatology, Volume 50, Issue 3, Page 290-298, March 2023., 2023
Abstract More than 200 types of human papillomavirus (HPV) have been reported to date and have been associated with various dermatological diseases. Among dermatological diseases, viral verrucae are the most commonly reported to be associated with HPV.
Akira Shimizu, Reimon Yamaguchi, Yuko Kuriyama   +2 more
wiley   +1 more source

Mus musculus papillomavirus 1 is a key driver of skin cancer development upon immunosuppression

American Journal of Transplantation, Volume 21, Issue 2, Page 525-539, February 2021., 2021
Epidemiological and experimental data implicate cutaneous human papillomavirus infection as co‐factor in the development of cutaneous squamous cell carcinomas (cSCCs), particularly in immunocompromised organ transplant recipients (OTRs). Herein, we established and characterized a skin cancer model, in which Mus musculus papillomavirus 1 (MmuPV1 ...
Sonja Dorfer, Katharina Strasser, Georg Schröckenfuchs, Michael Bonelli, Wolfgang Bauer, Harald Kittler, Christophe Cataisson, Michael B. Fischer, Beate M. Lichtenberger, Alessandra Handisurya   +9 more
wiley   +1 more source

A Novel Model for Papillomavirus-Mediated Anal Disease and Cancer Using the Mouse Papillomavirus

mBio, 2021
Up to 95% of all anal cancers are associated with infection by human papillomavirus (HPV); however, no established preclinical model exists for high-grade anal disease and cancer mediated by a natural papillomavirus infection.
Simon Blaine-Sauer, Myeong-Kyun Shin, Kristina A. Matkowskyj, Ella Ward-Shaw, Paul F. Lambert   +4 more
doaj   +1 more source