Mus musculus papillomavirus 1 is a key driver of skin cancer development upon immunosuppression
American Journal of Transplantation, Volume 21, Issue 2, Page 525-539, February 2021., 2021 Epidemiological and experimental data implicate cutaneous human papillomavirus infection as co‐factor in the development of cutaneous squamous cell carcinomas (cSCCs), particularly in immunocompromised organ transplant recipients (OTRs). Herein, we established and characterized a skin cancer model, in which Mus musculus papillomavirus 1 (MmuPV1 ...
Sonja Dorfer +9 more
wiley +1 more source
A Novel Model for Papillomavirus-Mediated Anal Disease and Cancer Using the Mouse Papillomavirus
mBio, 2021 Up to 95% of all anal cancers are associated with infection by human papillomavirus (HPV); however, no established preclinical model exists for high-grade anal disease and cancer mediated by a natural papillomavirus infection.
Simon Blaine-Sauer +4 more
doaj +1 more source
The antiviral effects of a MEK1/2 inhibitor promote tumor regression in a preclinical model of human papillomavirus infection-induced tumorigenesis. [PDF]
Antiviral Res, 2023 Human papillomaviruses (HPVs) are a significant public health concern due to their widespread transmission, morbidity, and oncogenic potential. Despite efficacious vaccines, millions of unvaccinated individuals and those with existing infections will ...
Luna AJ +7 more
europepmc +2 more sources
Anal squamous cell carcinomas in KC mice were negative for MmuPV1 infection.
, 2021 (A) No viral signatures were detected in representative anal tumors from KC mice stained via RNAScope ISH with a probe specific to the MmuPV1 E4 region of the genome.
Manabu Nukaya (137154) +7 more
core +1 more source
Deficiency in <i>Ever2</i> does not increase susceptibility of mice to pathogenesis by the mouse papillomavirus, MmuPV1. [PDF]
J VirolABSTRACT Epidermodysplasia verruciformis (EV) is a rare genetic skin disorder that is characterized by the development of papillomavirus-induced skin lesions that can progress to squamous cell carcinoma (SCC).
Torres AD +6 more
europepmc +3 more sources
An Infection-Based Murine Model for Papillomavirus-Associated Head and Neck Cancer
mBio, 2020 Human papillomavirus (HPV) is the most common sexually transmitted pathogen, and high-risk HPVs contribute to 5% of human cancers, including 25% of head and neck squamous cell carcinomas (HNSCCs).
Tao Wei +3 more
doaj +1 more source
A lysine at amino acid position 81 in MmuPV1 E7 is critical for the interaction with PTPN14.
, 2023 NIH 3T3 cells were transfected with either empty vector (N) or plasmid constructs that express N-terminally and C-terminally HA/FLAG epitope-tagged HPV16 E7, WT MmuPV1 E7, or MmuPV1 E7K81S mutant.
Nathalie Lavoie (2293762) +12 more
core +1 more source
mBio, 2019 Papillomaviruses exhibit species-specific tropism, thereby limiting understanding and research of several aspects of HPV infection and carcinogenesis.
Megan E. Spurgeon +5 more
doaj +1 more source
A novel lineage-tracing mouse model for MmuPV1 infection enables in vivo studies in the absence of cytopathic effects [PDF]
, 2021 Abstract Human papillomaviruses (HPVs) are DNA viruses that ubiquitously infect humans and have been associated with hyperproliferative lesions. The recently discovered mouse specific papillomavirus, MmuPV1, provides the opportunity to study papillomavirus infections in vivo in the ...
Vural Yilmaz +2 more
openaire +1 more source
Sequence verification of MmuPV1 E7 in lesions infected with the E7K81S mutant genome.
, 2023 DNA was isolated from FFPE tissue sections and then subjected to PCR for the MmuPV1 E7 gene. PCR products were sent for sequencing to verify presence of the E7K81S mutation. A representative sequencing result is shown. (TIF)
Nathalie Lavoie (2293762) +12 more
core +1 more source