Results 51 to 60 of about 312 (97)

Depo Medroxyprogesterone (DMPA) Promotes Papillomavirus Infections but Does Not Accelerate Disease Progression in the Anogenital Tract of a Mouse Model

Viruses, 2022
Contraceptives such as Depo-medroxyprogesterone (DMPA) are used by an estimated 34 million women worldwide. DMPA has been associated with increased risk of several viral infections including Herpes simplex virus-2 (HSV-2) and Human immunodeficiency virus
Jiafen Hu, Sarah A. Brendle, Jingwei J. Li, Vonn Walter, Nancy M. Cladel, Timothy Cooper, Debra A. Shearer, Karla K. Balogh, Neil D. Christensen   +8 more
doaj   +1 more source

The human papillomavirus late life cycle and links to keratinocyte differentiation

Journal of Medical Virology, Volume 96, Issue 2, February 2024.
Abstract Regulation of human papillomavirus (HPV) gene expression is tightly linked to differentiation of the keratinocytes the virus infects. HPV late gene expression is confined to the cells in the upper layers of the epithelium where the virus capsid proteins are synthesized.
Anna Kirk, Sheila V. Graham
wiley   +1 more source

Functions of Papillomavirus E8^E2 Proteins in Tissue Culture and In Vivo

Viruses, 2022
Papillomaviruses (PV) replicate in undifferentiated keratinocytes at low levels and to high levels in differentiated cells. The restricted replication in undifferentiated cells is mainly due to the expression of the conserved viral E8^E2 repressor ...
Franziska Kuehner, Frank Stubenrauch
doaj   +1 more source

A novel pre-clinical murine model to study the life cycle and progression of cervical and anal papillomavirus infections. [PDF]

PLoS ONE, 2015
Papillomavirus disease and associated cancers remain a significant health burden in much of the world. The current protective vaccines, Gardasil and Cervarix, are expensive and not readily available to the underprivileged.
Nancy M Cladel, Lynn R Budgeon, Karla K Balogh, Timothy K Cooper, Jiafen Hu, Neil D Christensen   +5 more
doaj   +1 more source

Rodent Papillomaviruses

Viruses, 2017
Preclinical infection model systems are extremely valuable tools to aid in our understanding of Human Papillomavirus (HPV) biology, disease progression, prevention, and treatments.
Aayushi Uberoi, Paul F. Lambert
doaj   +1 more source

Deficiency of Cathelicidin-related Antimicrobial Peptide Promotes Skin Papillomatosis in Mus musculus Papillomavirus 1-infected Mice

Acta Dermato-Venereologica, 2021
Cathelicidins have been reported to inhibit human papillomavirus infection in vitro; however, nothing is known about their activity in vivo. In this study, experimental skin infection with Mus musculus papillomavirus 1 resulted in robust development of ...
Sonja Dorfer, Katharina Strasser, Siegfried Reipert, Michael B. Fischer, Saeed Shafti-Keramat, Michael Bonelli, Georg Schröckenfuchs, Wolfgang Bauer, Stefanie Kancz, Lena Müller, Alessandra Handisurya   +10 more
doaj   +1 more source

A Mouse Model of Oropharyngeal Papillomavirus-Induced Neoplasia Using Novel Tools for Infection and Nasal Anesthesia

Viruses, 2020
Human head and neck cancers that develop from the squamous cells of the oropharynx (Oropharyngeal Squamous Cell Carcinomas or OPSCC) are commonly associated with the papillomavirus infection.
Andrea Bilger, Renee E. King, Josh P. Schroeder, Jared T. Piette, Louis A. Hinshaw, Andrew D. Kurth, Ronnie W. AlRamahi, Matthew V. Barthel, Ella T. Ward-Shaw, Darya Buehler, Kristyn S. Masters, Susan L. Thibeault, Paul F. Lambert   +12 more
doaj   +1 more source

MmuPV1 L1- cytokeratin dual immunofluorescence using home-based tyramide signal amplification v1

, 2017
To accomplish MmuPV L1-K14 double fluorescent staining we made use of tyramide-based signal amplification (TSA) technique. This technique allows for easy multiplexing of immunofluorescent staining but perhaps its biggest advantage is that it permits double immunofluorescent staining using two unconjugated primary antisera raised in the same species. We
Aayushi Uberoi, Satoshi Yoshida, Paul Lambert   +2 more
openaire   +1 more source

Stress keratin 17 enhances papillomavirus infection-induced disease by downregulating T cell recruitment.

PLoS Pathogens, 2020
High-risk human papillomaviruses (HPVs) cause 5% of human cancers. Despite the availability of HPV vaccines, there remains a strong urgency to find ways to treat persistent HPV infections, as current HPV vaccines are not therapeutic for individuals ...
Wei Wang, Aayushi Uberoi, Megan Spurgeon, Ellery Gronski, Vladimir Majerciak, Alexei Lobanov, Mitchell Hayes, Amanda Loke, Zhi-Ming Zheng, Paul F Lambert   +9 more
doaj   +1 more source

Estrogen receptor α (Esr1) mediates estrogen’s ability to promote papillomavirus-induced cutaneous disease in male and female mice

mBio
Persistent papillomavirus infection is a key driver of neoplastic progression in both mucosal and cutaneous epithelia. Although estrogen is a well-established cofactor in HPV-associated cervical carcinogenesis, its role in cutaneous papillomavirus ...
Sheikh A. Umar, Wei Wang, Donghwan Jeon, Lam Khue Pham, Ella T. Ward-Shaw, Denis Lee, Rong Hu, Andrea Bilger, Megan E. Spurgeon, Paul F. Lambert   +9 more
doaj   +1 more source