Key aspects of papillomavirus infection influence the host cervicovaginal microbiome in a preclinical murine papillomavirus (MmuPV1) infection model [PDF]
mBioHuman papillomaviruses (HPVs) are the most common sexually transmitted infection in the United States and are a major etiological agent of cancers in the anogenital tract and oral cavity.
Megan E. Spurgeon +8 more
doaj +4 more sources
Protocol for in vivo lineage tracing of the mouse-papillomavirus-type 1-infected cells in mice [PDF]
STAR Protocols, 2023 Summary: Here, we present a protocol to create an in vivo lineage-tracing mouse model for mouse-papillomavirus-type 1 (MmuPV1)-infected cells. We describe the steps to generate and deliver the MmuPV1 lox-Cre-lox plasmid for the infection of mice ...
Vural Yilmaz, Katerina Strati
doaj +3 more sources
Immune status, strain background, and anatomic site of inoculation affect mouse papillomavirus (MmuPV1) induction of exophytic papillomas or endophytic trichoblastomas. [PDF]
PLoS ONE, 2014 Papillomaviruses (PVs) induce papillomas, premalignant lesions, and carcinomas in a wide variety of species. PVs are classified first based on their host and tissue tropism and then their genomic diversities.
John P Sundberg +8 more
doaj +6 more sources
Characterization of a Chimeric MmuPV1 Genome with HPV-16E6E7
Proceedings of IMPRS, 2023 Background/Objectives: Papilloma Viruses (PVs) are double-stranded DNA viruses that infect cutaneous and mucosal epithelium. In humans, there are over 100 types of PVs. HPV-16 is a high-risk type that causes ~50% of cervical cancers and ~70% of oropharyngeal cancers by expressing viral oncogenes E6 and E7 in replicating keratinocytes.
Josephine Pyles +3 more
openaire +3 more sources
Sexual transmission of murine papillomavirus (MmuPV1) in Mus musculus
eLife, 2019 Human papillomaviruses (HPVs) are the most common sexually transmitted infectious agents. Because of the species specificity of HPVs, study of their natural transmission in laboratory animals is not possible.
Megan E Spurgeon, Paul F Lambert
doaj +3 more sources
Mus musculus papillomavirus 1 E8^E2 represses expression of late protein E4 in basal-like keratinocytes via NCoR/SMRT-HDAC3 co-repressor complexes to enable wart formation in vivo [PDF]
mBio, 2023 High-risk human papillomaviruses (PV) account for approximately 600,000 new cancers per year. The early protein E8^E2 is a conserved repressor of PV replication, whereas E4 is a late protein that arrests cells in G2 and collapses keratin filaments to ...
Franziska Kuehner +6 more
doaj +2 more sources
Cryo EM Analysis Reveals Inherent Flexibility of Authentic Murine Papillomavirus Capsids
Viruses, 2021 Human papillomavirus (HPV) is a significant health burden and leading cause of virus-induced cancers. However, studies have been hampered due to restricted tropism that makes production and purification of high titer virus problematic.
Samantha R. Hartmann +6 more
doaj +2 more sources
Role of Ultraviolet Radiation in Papillomavirus-Induced Disease. [PDF]
PLoS Pathogens, 2016 Human papillomaviruses are causally associated with 5% of human cancers. The recent discovery of a papillomavirus (MmuPV1) that infects laboratory mice provides unique opportunities to study the life cycle and pathogenesis of papillomaviruses in the ...
Aayushi Uberoi +4 more
doaj +2 more sources
The Larynx is Protected from Secondary and Vertical Papillomavirus Infection in Immunocompetent Mice. [PDF]
LaryngoscopeIn humans, human papillomaviruses that cause recurrent respiratory papillomatosis can spread to the larynx from other tissue sites (secondary infection), and to the larynx of infants from genitally infected mothers (vertical infection). We examined larynges of over 430 immunocompetent adult and juvenile mice infected with mouse papillomavirus MmuPV1 in
King RE +8 more
europepmc +2 more sources
Increased Susceptibility of WHIM Mice to Papillomavirus-induced Disease is Dependent upon Immune Cell Dysfunction. [PDF]
PLoS PathogensWarts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) syndrome is a rare primary immunodeficiency disease in humans caused by a gain of function in CXCR4, mostly due to inherited heterozygous mutations in CXCR4. One major clinical symptom of
Wei Wang +5 more
doaj +2 more sources