Immune status, strain background, and anatomic site of inoculation affect mouse papillomavirus (MmuPV1) induction of exophytic papillomas or endophytic trichoblastomas. [PDF]
PLoS ONE, 2014 Papillomaviruses (PVs) induce papillomas, premalignant lesions, and carcinomas in a wide variety of species. PVs are classified first based on their host and tissue tropism and then their genomic diversities.
John P Sundberg +8 more
doaj +6 more sources
Characterization of a Chimeric MmuPV1 Genome with HPV-16E6E7 [PDF]
Proceedings of IMPRS, 2023 Background/Objectives: Papilloma Viruses (PVs) are double-stranded DNA viruses that infect cutaneous and mucosal epithelium. In humans, there are over 100 types of PVs.
DeSmet, Marsha +3 more
core +3 more sources
A novel lineage-tracing mouse model for studying early MmuPV1 infections
eLife, 2022 Human papillomaviruses are DNA viruses that ubiquitously infect humans and have been associated with hyperproliferative lesions. The recently discovered mouse specific papillomavirus (MmuPV1) provides the opportunity to study papillomavirus infections in
Vural Yilmaz +4 more
doaj +3 more sources
Sexual transmission of murine papillomavirus (MmuPV1) in Mus musculus
eLife, 2019 Human papillomaviruses (HPVs) are the most common sexually transmitted infectious agents. Because of the species specificity of HPVs, study of their natural transmission in laboratory animals is not possible.
Megan E Spurgeon, Paul F Lambert
doaj +3 more sources
Viruses, 2022 Recurrent respiratory papillomatosis (RRP), caused by laryngeal infection with low-risk human papillomaviruses, has devastating effects on vocal communication and quality of life.
Renee E. King +6 more
doaj +2 more sources
Mus musculus papillomavirus 1 E8^E2 represses expression of late protein E4 in basal-like keratinocytes via NCoR/SMRT-HDAC3 co-repressor complexes to enable wart formation in vivo [PDF]
mBio, 2023 High-risk human papillomaviruses (PV) account for approximately 600,000 new cancers per year. The early protein E8^E2 is a conserved repressor of PV replication, whereas E4 is a late protein that arrests cells in G2 and collapses keratin filaments to ...
Franziska Kuehner +6 more
doaj +2 more sources
Role of Ultraviolet Radiation in Papillomavirus-Induced Disease. [PDF]
PLoS Pathogens, 2016 Human papillomaviruses are causally associated with 5% of human cancers. The recent discovery of a papillomavirus (MmuPV1) that infects laboratory mice provides unique opportunities to study the life cycle and pathogenesis of papillomaviruses in the ...
Aayushi Uberoi +4 more
doaj +2 more sources
Cryo EM Analysis Reveals Inherent Flexibility of Authentic Murine Papillomavirus Capsids
Viruses, 2021 Human papillomavirus (HPV) is a significant health burden and leading cause of virus-induced cancers. However, studies have been hampered due to restricted tropism that makes production and purification of high titer virus problematic.
Samantha R. Hartmann +6 more
doaj +2 more sources
The Larynx is Protected from Secondary and Vertical Papillomavirus Infection in Immunocompetent Mice. [PDF]
LaryngoscopeIn humans, human papillomaviruses that cause recurrent respiratory papillomatosis can spread to the larynx from other tissue sites (secondary infection), and to the larynx of infants from genitally infected mothers (vertical infection). We examined larynges of over 430 immunocompetent adult and juvenile mice infected with mouse papillomavirus MmuPV1 in
King RE +8 more
europepmc +2 more sources
Estrogen receptor α (Esr1) mediates estrogen’s ability to promote papillomavirus-induced cutaneous disease in male and female mice [PDF]
mBioPersistent papillomavirus infection is a key driver of neoplastic progression in both mucosal and cutaneous epithelia. Although estrogen is a well-established cofactor in HPV-associated cervical carcinogenesis, its role in cutaneous papillomavirus ...
Sheikh A. Umar +9 more
doaj +2 more sources