Results 21 to 30 of about 312 (97)

Sexual transmission of murine papillomavirus (MmuPV1) in Mus musculus

eLife, 2019
Human papillomaviruses (HPVs) are the most common sexually transmitted infectious agents. Because of the species specificity of HPVs, study of their natural transmission in laboratory animals is not possible.
Megan E Spurgeon, Paul F Lambert
doaj   +3 more sources

A Novel In Vivo Model of Laryngeal Papillomavirus-Associated Disease Using Mus musculus Papillomavirus [PDF]

Viruses, 2022
Recurrent respiratory papillomatosis (RRP), caused by laryngeal infection with low-risk human papillomaviruses, has devastating effects on vocal communication and quality of life.
Renee E. King, Andrea Bilger, Josef Rademacher, Ella T. Ward-Shaw, Rong Hu, Paul F. Lambert, Susan L. Thibeault   +6 more
doaj   +2 more sources

Mus musculus papillomavirus 1 E8^E2 represses expression of late protein E4 in basal-like keratinocytes via NCoR/SMRT-HDAC3 co-repressor complexes to enable wart formation in vivo [PDF]

mBio, 2023
High-risk human papillomaviruses (PV) account for approximately 600,000 new cancers per year. The early protein E8^E2 is a conserved repressor of PV replication, whereas E4 is a late protein that arrests cells in G2 and collapses keratin filaments to ...
Franziska Kuehner, Margaret Wong, Elke Straub, John Doorbar, Thomas Iftner, Richard B. S. Roden, Frank Stubenrauch   +6 more
doaj   +2 more sources

Protocol for in vivo lineage tracing of the mouse-papillomavirus-type 1-infected cells in mice [PDF]

STAR Protocols, 2023
Summary: Here, we present a protocol to create an in vivo lineage-tracing mouse model for mouse-papillomavirus-type 1 (MmuPV1)-infected cells. We describe the steps to generate and deliver the MmuPV1 lox-Cre-lox plasmid for the infection of mice ...
Vural Yilmaz, Katerina Strati
doaj   +2 more sources

The Larynx is Protected from Secondary and Vertical Papillomavirus Infection in Immunocompetent Mice. [PDF]

Laryngoscope
In humans, human papillomaviruses that cause recurrent respiratory papillomatosis can spread to the larynx from other tissue sites (secondary infection), and to the larynx of infants from genitally infected mothers (vertical infection). We examined larynges of over 430 immunocompetent adult and juvenile mice infected with mouse papillomavirus MmuPV1 in
King RE, Rademacher J, Ward-Shaw ET, Hu R, Bilger A, Blaine-Sauer S, Spurgeon ME, Thibeault SL, Lambert PF.   +8 more
europepmc   +2 more sources

Increased Susceptibility of WHIM Mice to Papillomavirus-induced Disease is Dependent upon Immune Cell Dysfunction. [PDF]

PLoS Pathogens
Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) syndrome is a rare primary immunodeficiency disease in humans caused by a gain of function in CXCR4, mostly due to inherited heterozygous mutations in CXCR4. One major clinical symptom of
Wei Wang, Ali Pope, Ella Ward-Shaw, Darya Buehler, Francoise Bachelerie, Paul F Lambert   +5 more
doaj   +2 more sources

Efficacy of Topically Administered Dihydroartemisinin in Treating Papillomavirus-Induced Anogenital Dysplasia in Preclinical Mouse Models [PDF]

Viruses, 2022
The artemisinin family of compounds is cytopathic in certain cancer cell lines that are positive for human papillomaviruses (HPV) and can potentially drive the regression of dysplastic lesions. We evaluated the efficacy of topical dihydroartemisinin (DHA)
Laura C. Gunder, Simon Blaine-Sauer, Hillary R. Johnson, Myeong-Kyun Shin, Andrew S. Auyeung, Wei Zhang, Glen E. Leverson, Ella T. Ward-Shaw, Renee E. King, Stephanie M. McGregor, Kristina A. Matkowskyj, Paul F. Lambert, Evie H. Carchman   +12 more
doaj   +2 more sources

Monitoring mouse papillomavirus-associated cancer development using longitudinal Pap smear screening [PDF]

mBio
A substantial percentage of the population remains at risk for cervical cancer due to pre-existing human papillomavirus (HPV) infections, despite prophylactic vaccines. Early diagnosis and treatment are crucial for better disease outcomes.
Hannah M. Atkins, Aysegul Aksakal Uslu, Jingwei J. Li, Debra A. Shearer, Sarah A. Brendle, Chen Han, Michael Kozak, Paul Lopez, Deesha Nayar, Karla K. Balogh, Catherine Abendroth, Jean Copper, Keith C. Cheng, Neil D. Christensen, Yusheng Zhu, Stefanie Avril, Adam D. Burgener, Thomas T. Murooka, Jiafen Hu   +18 more
doaj   +2 more sources

Intraperitoneal delivery of cannabidiol (CBD) and Δ9-tetrahydocannabinol (THC) promotes papillomavirus infections in athymic nude mice [PDF]

Tumour Virus Research
We used our mouse papillomavirus (MmuPV1) model to test the hypothesis that two primary psychoactive ingredients of marijuana, Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), promote papillomavirus persistence in the oral mucosa of infected mice. We
Sarah A. Brendle, Jingwei Li, Dongxiao Sun, Junjia Zhu, Angela N. Henderson-Redmond, Daniel J. Morgan, Karla K. Balogh, Danielle Covington, Debra A. Shearer, Jiafen Hu   +9 more
doaj   +2 more sources

Immune status, strain background, and anatomic site of inoculation affect mouse papillomavirus (MmuPV1) induction of exophytic papillomas or endophytic trichoblastomas. [PDF]

PLoS ONE, 2014
Papillomaviruses (PVs) induce papillomas, premalignant lesions, and carcinomas in a wide variety of species. PVs are classified first based on their host and tissue tropism and then their genomic diversities.
John P Sundberg, Timothy M Stearns, Joongho Joh, Mary Proctor, Arvind Ingle, Kathleen A Silva, Soheil S Dadras, A Bennett Jenson, Shin-je Ghim   +8 more
doaj   +5 more sources