Mus musculus papillomavirus MmuPV1 resists restriction by human APOBEC3B [PDF]
Journal of VirologyThe single-stranded DNA deaminase APOBEC3B (A3B) is capable of potently restricting the replication of a range of viruses, including retroviruses (cDNA) and herpesviruses (genomic DNA). However, these and likely other DNA virus families have evolved host
Xingyu Liu +14 more
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CD28-deficient mice are vulnerable to mouse papillomavirus MmuPV1 infection of the skin and mucosae. [PDF]
PLoS PathogensCD28 is a co-stimulatory molecule expressed on the surface of T cells. To date, three individuals with germline CD28 deficiency have been reported to develop recalcitrant, HPV-driven warts: one exhibited persistent lesions, another experienced disease ...
Sarah Brendle +15 more
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Viruses, 2022 Laryngeal infection with low-risk human papillomaviruses can cause recurrent respiratory papillomatosis (RRP), a disease with severe effects on vocal fold epithelium resulting in impaired voice function and communication. RRP research has been stymied by
Paul Lambert +2 more
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A novel lineage-tracing mouse model for studying early MmuPV1 infections [PDF]
eLife, 2022 Human papillomaviruses are DNA viruses that ubiquitously infect humans and have been associated with hyperproliferative lesions. The recently discovered mouse specific papillomavirus (MmuPV1) provides the opportunity to study papillomavirus infections in
Vural Yilmaz +4 more
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The full transcription map of mouse papillomavirus type 1 (MmuPV1) in mouse wart tissues [PDF]
PLoS Pathogens, 2017 Mouse papillomavirus type 1 (MmuPV1) provides, for the first time, the opportunity to study infection and pathogenesis of papillomaviruses in the context of laboratory mice.
Zhi-Ming Zheng +2 more
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PLoS Pathogens, 2021 MmuPV1 is a useful model for studying papillomavirus-induced tumorigenesis. We used RNA-seq to look for chimeric RNAs that map to both MmuPV1 and host genomes.
Zhi-Ming Zheng +2 more
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MmuPV1-Induced Cutaneous Squamous Cell Carcinoma Arises Preferentially from Lgr5+ Epithelial Progenitor Cells [PDF]
Viruses, 2022 Murine papillomavirus, MmuPV1, causes natural infections in laboratory mice that can progress to squamous cell carcinoma (SCC) making it a useful preclinical model to study the role of papillomaviruses in cancer.
Ruben Moreno +2 more
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Key aspects of papillomavirus infection influence the host cervicovaginal microbiome in a preclinical murine papillomavirus (MmuPV1) infection model [PDF]
mBioHuman papillomaviruses (HPVs) are the most common sexually transmitted infection in the United States and are a major etiological agent of cancers in the anogenital tract and oral cavity.
Megan E. Spurgeon +8 more
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Cutaneous HPV8 and MmuPV1 E6 Proteins Target the NOTCH and TGF-β Tumor Suppressors to Inhibit Differentiation and Sustain Keratinocyte Proliferation [PDF]
PLoS Pathogens, 2017 Cutaneous beta-papillomaviruses are associated with non-melanoma skin cancers that arise in patients who suffer from a rare genetic disorder, Epidermodysplasia verruciformis (EV) or after immunosuppression following organ transplantation.
Paul Lambert +2 more
exaly +7 more sources
MmuPV1 infection of Tmc6/Ever1 or Tmc8/Ever2 deficient FVB mice as a model of βHPV in typical epidermodysplasia verruciformis. [PDF]
PLoS PathogensTypical epidermodysplasia verruciformis (EV) is a rare, autosomal recessive disorder characterized by an unusual susceptibility to infection with specific skin-trophic types of human papillomavirus, principally betapapillomaviruses, and a propensity for ...
Margaret Wong +9 more
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