E2 Tyrosine 102 Regulates MmuPV1 Pathogenesis In Vivo [PDF]
PathogensThe papillomavirus (PV) life cycle is strictly controlled and can be divided into the following three distinct stages: initial infection, maintenance, and amplification.
Jessica Gonzalez +5 more
doaj +6 more sources
The full transcription map of mouse papillomavirus type 1 (MmuPV1) in mouse wart tissues [PDF]
PLoS Pathogens, 2017 Mouse papillomavirus type 1 (MmuPV1) provides, for the first time, the opportunity to study infection and pathogenesis of papillomaviruses in the context of laboratory mice.
Xiangyang Xue +2 more
exaly +6 more sources
PLoS Pathogens, 2021 MmuPV1 is a useful model for studying papillomavirus-induced tumorigenesis. We used RNA-seq to look for chimeric RNAs that map to both MmuPV1 and host genomes.
Lulu Yu +2 more
exaly +6 more sources
Cutaneous HPV8 and MmuPV1 E6 Proteins Target the NOTCH and TGF-β Tumor Suppressors to Inhibit Differentiation and Sustain Keratinocyte Proliferation [PDF]
PLoS Pathogens, 2017 Cutaneous beta-papillomaviruses are associated with non-melanoma skin cancers that arise in patients who suffer from a rare genetic disorder, Epidermodysplasia verruciformis (EV) or after immunosuppression following organ transplantation.
Aayushi Uberoi +2 more
exaly +8 more sources
MmuPV1 infection of Tmc6/Ever1 or Tmc8/Ever2 deficient FVB mice as a model of βHPV in typical epidermodysplasia verruciformis. [PDF]
PLoS PathogensTypical epidermodysplasia verruciformis (EV) is a rare, autosomal recessive disorder characterized by an unusual susceptibility to infection with specific skin-trophic types of human papillomavirus, principally betapapillomaviruses, and a propensity for ...
Margaret Wong +9 more
doaj +5 more sources
Identification and Characterization of MmuPV1 Causing Papillomatosis Outbreak in an Animal Research Facility [PDF]
VirusesMouse papillomavirus (MmuPV1) is the first papillomavirus known to infect laboratory mice, making it an irreplaceable tool for research on papillomaviruses. Despite wide use, standardized techniques for conducting MmuPV1 animal research are lacking.
Vladimir Majerciak +10 more
doaj +4 more sources
Mus musculus papillomavirus MmuPV1 resists restriction by human APOBEC3B [PDF]
Journal of VirologyThe single-stranded DNA deaminase APOBEC3B (A3B) is capable of potently restricting the replication of a range of viruses, including retroviruses (cDNA) and herpesviruses (genomic DNA). However, these and likely other DNA virus families have evolved host
Xingyu Liu +14 more
doaj +5 more sources
CD28-deficient mice are vulnerable to mouse papillomavirus MmuPV1 infection of the skin and mucosae. [PDF]
PLoS PathogensCD28 is a co-stimulatory molecule expressed on the surface of T cells. To date, three individuals with germline CD28 deficiency have been reported to develop recalcitrant, HPV-driven warts: one exhibited persistent lesions, another experienced disease ...
Sarah Brendle +15 more
doaj +4 more sources
A novel lineage-tracing mouse model for studying early MmuPV1 infections [PDF]
eLife, 2022 Human papillomaviruses are DNA viruses that ubiquitously infect humans and have been associated with hyperproliferative lesions. The recently discovered mouse specific papillomavirus (MmuPV1) provides the opportunity to study papillomavirus infections in
Vural Yilmaz +4 more
doaj +4 more sources
A Novel In Vivo Model of Laryngeal Papillomavirus-Associated Disease Using Mus musculus Papillomavirus [PDF]
Viruses, 2022 Recurrent respiratory papillomatosis (RRP), caused by laryngeal infection with low-risk human papillomaviruses, has devastating effects on vocal communication and quality of life.
Renee E. King +6 more
doaj +3 more sources