Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model [PDF]
Pathogens, 2023 Human papillomavirus (HPV)-induced oropharyngeal cancer now exceeds HPV-induced cervical cancer, with a noticeable sex bias. Although it is well established that women have a more proficient immune system, it remains unclear whether immune control of ...
Sarah A. Brendle +10 more
doaj +5 more sources
CD28-deficient mice are vulnerable to mouse papillomavirus MmuPV1 infection of the skin and mucosae. [PDF]
PLoS PathogensCD28 is a co-stimulatory molecule expressed on the surface of T cells. To date, three individuals with germline CD28 deficiency have been reported to develop recalcitrant, HPV-driven warts: one exhibited persistent lesions, another experienced disease ...
Sarah Brendle +15 more
doaj +6 more sources
The full transcription map of mouse papillomavirus type 1 (MmuPV1) in mouse wart tissues [PDF]
PLoS Pathogens, 2017 Mouse papillomavirus type 1 (MmuPV1) provides, for the first time, the opportunity to study infection and pathogenesis of papillomaviruses in the context of laboratory mice.
Zhi-Ming Zheng +2 more
exaly +6 more sources
PLoS Pathogens, 2021 MmuPV1 is a useful model for studying papillomavirus-induced tumorigenesis. We used RNA-seq to look for chimeric RNAs that map to both MmuPV1 and host genomes.
Zhi-Ming Zheng +2 more
exaly +6 more sources
Cutaneous HPV8 and MmuPV1 E6 Proteins Target the NOTCH and TGF-β Tumor Suppressors to Inhibit Differentiation and Sustain Keratinocyte Proliferation [PDF]
PLoS Pathogens, 2017 Cutaneous beta-papillomaviruses are associated with non-melanoma skin cancers that arise in patients who suffer from a rare genetic disorder, Epidermodysplasia verruciformis (EV) or after immunosuppression following organ transplantation.
Paul Lambert +2 more
exaly +8 more sources
MmuPV1 infection of Tmc6/Ever1 or Tmc8/Ever2 deficient FVB mice as a model of βHPV in typical epidermodysplasia verruciformis. [PDF]
PLoS PathogensTypical epidermodysplasia verruciformis (EV) is a rare, autosomal recessive disorder characterized by an unusual susceptibility to infection with specific skin-trophic types of human papillomavirus, principally betapapillomaviruses, and a propensity for ...
Margaret Wong +9 more
doaj +5 more sources
Mus musculus papillomavirus MmuPV1 resists restriction by human APOBEC3B [PDF]
Journal of VirologyThe single-stranded DNA deaminase APOBEC3B (A3B) is capable of potently restricting the replication of a range of viruses, including retroviruses (cDNA) and herpesviruses (genomic DNA). However, these and likely other DNA virus families have evolved host
Xingyu Liu +14 more
doaj +5 more sources
Viruses, 2022 Murine papillomavirus, MmuPV1, causes natural infections in laboratory mice that can progress to squamous cell carcinoma (SCC) making it a useful preclinical model to study the role of papillomaviruses in cancer.
Ruben Moreno +2 more
doaj +4 more sources
Key aspects of papillomavirus infection influence the host cervicovaginal microbiome in a preclinical murine papillomavirus (MmuPV1) infection model [PDF]
mBioHuman papillomaviruses (HPVs) are the most common sexually transmitted infection in the United States and are a major etiological agent of cancers in the anogenital tract and oral cavity.
Megan E. Spurgeon +8 more
doaj +4 more sources
Protocol for in vivo lineage tracing of the mouse-papillomavirus-type 1-infected cells in mice [PDF]
STAR Protocols, 2023 Summary: Here, we present a protocol to create an in vivo lineage-tracing mouse model for mouse-papillomavirus-type 1 (MmuPV1)-infected cells. We describe the steps to generate and deliver the MmuPV1 lox-Cre-lox plasmid for the infection of mice ...
Vural Yilmaz, Katerina Strati
doaj +3 more sources