Results 91 to 100 of about 887,744 (175)

Hippo pathway disruption and YAP1 activation in anogenital papillary squamous intraepithelial lesion

Histopathology, EarlyView.
Disruption of the Hippo Pathway with YAP1 activation is a consistent finding in papillary squamous intraepithelial lesions and may underlie their altered epithelial maturation and HPV E6/E7 expression patterns, providing new insight into the pathogenesis of this distinct low‐risk HPV‐associated lesion.
Gloria Zhang, Karen L. Talia, W. Glenn McCluggage, Robert A. Soslow, Bin Yang   +4 more
wiley   +1 more source

Bovine papillomavirus: old system, new lessons? [PDF]

, 2006
No abstract ...
Campo, M.S.
core   +4 more sources

Small molecule NMD and MDM2 inhibitors synergistically trigger apoptosis in HeLa cells

Molecules and Cells
: The nonsense-mediated mRNA decay (NMD) pathway and the p53 pathway, linked to tumorgenesis, are also promising targets for cancer treatment. NMD plays an important role in RNA quality control, while the p53 pathway is involved in cancer suppression ...
Ying Li, Li Wan, Hexin Li, Xiaokun Tang, Siyuan Xu, Gaoyuan Sun, Wei Huang, Min Tang   +7 more
doaj   +1 more source

Male genital lichen sclerosus

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Male genital lichen sclerosus is driven by chronic, occluded exposure of susceptible genital epithelium to urine, rather than infection or autoimmunity. This review synthesizes clinical, anatomical and molecular evidence showing how microincontinence and occlusion initiate inflammation, fibrosis and carcinogenesis, and explains the curative effect of ...
Georgios Kravvas, Rory Barry, Richard E. Watchorn, Christopher B. Bunker   +3 more
wiley   +1 more source

Detection and genotyping of human Papillomavirus in urine samples from unvaccinated male and female adolescents in Italy [PDF]

, 2013
The introduction of vaccination against Human Papillomavirus (HPV) in adolescent girls in 2006 has focused virological surveillance on this age group. As few studies have evaluated HPV infections in young populations, further data are needed in order to ...
Zotti, CM, Boccalini, Sara, Elisabetta Tanzi, Gasparini Roberto, Coppola Rosa Cristina, R. Gasparini, Rosa Cristina Coppola, Coppola, RC, Gasparini R, Paolo Castiglia, M. Martinelli, M. Martinese, Panatto D, Silvia Bianchi, Amicizia, D, Amicizia D, Paolo Bonanni, Zotti CM, Elena Rosanna Frati, Bianchi S, Bianchi, S, Martinelli, M, Castiglia Paolo, Bianchi Silvia, D. Panatto, Marianna Martinelli, Meloni, Angelo, Tanzi Elisabetta, Amicizia, Daniela, G. Masia, Masia Giuseppina, Zotti, Carla Maria, Bianchi, Silvia, Daniela Amicizia, Bonanni, Paolo, Martinese M, Martinese, M, Masia G, Castiglia, Paolo Giuseppino, Tanzi, Elisabetta, S. Bianchi, Morena Martinese, C. M. Zotti, P. Castiglia, Coppola R C, Boccalini, S, Amicizia Daniela, Boccalini S, Martinelli Marianna, Bonanni Paolo, Bonanni P, Panatto, Donatella, Panatto Donatella, Frati, ER, Tanzi E, Zotti Carla Maria, Martinelli, Marianna, Frati ER, Piana Andrea, Tanzi, E., Piana A, Martinese, Morena, Gasparini, Roberto, Gasparini, R, Castiglia P, Donatella Panatto, Meloni Angelo, Martinese Morena, Sara Boccalini, D. Amicizia, E. Tanzi, Andrea Piana, P. Bonanni, Panatto, D, Meloni, A, Frati, Elena Rosanna, Masia, Giuseppina, Piana, Andrea Fausto, Boccalini Sara, Giuseppina Masia, R. C. Coppola, A. Meloni, E.R. Frati, Angelo Meloni, S. Boccalini, Roberto Gasparini, Frati Elena Rosanna, Masia, G, A. Piana, Martinelli M, Coppola, Rosa Cristina, Meloni A, Carla Maria Zotti, Bonanni, P   +93 more
core   +2 more sources

Viruses, Periodontitis, and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the viral involvement in periodontitis and its relevance for systemic diseases. The oral cavity acts as an active viral reservoir and dissemination platform, where virus–microbiome interactions may promote dysbiosis, periodontitis progression, and systemic inflammatory effects, while the ...
Kim Natalie Solte, Yvonne L. Hernandez‐Kapila, Henrik Dommisch   +2 more
wiley   +1 more source

The effect of photodynamic therapy in head and neck cancer: A comprehensive review of in vivo models

Photochemistry and Photobiology, EarlyView.
This review evaluates Photodynamic Therapy (PDT) in in vivo head and neck cancer models. PDT effectively generates ROS, reducing tumor growth, cell proliferation and angiogenesis while enhancing survival and immune responses. However, methodological heterogeneity highlights the urgent need for standardized dosimetric protocols to ensure reproducibility
Bibiana Padilha de Menezes da Silva, Rebeca Barros Nascimento, Giovanna Lopes Carvalho, Rebeca Boltes Cecatto, Maria Stella Moreira, Maria Fernanda Setúbal Destro Rodrigues   +5 more
wiley   +1 more source

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, Volume 159, Issue 8, Page 1857-1872, 15 October 2026.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

HPV-18 transformed cells fail to arrest in G1 in response to quercetin treatment [PDF]

, 2005
Previous work with primary human keratinocytes demonstrated that quercetin, a potent mutagen found in high levels in bracken fern (Pteridium aquilinum), arrested cells in G1 with concomitant elevation of the cyclin-dependent kinase inhibitor (cdki ...
Beniston, R.G., Campo, M.S.
core   +1 more source

Human Papillomaviruses in Buschke-Lowenstein Tumors: Physical State of the DNA and Identification of a Tandem Duplication in the Noncoding Region of a Human Papillomavirus 6 Subtype [PDF]

, 1986
Six Buschke-Löwenstein tumors, i.e., highly differentiated squamous cell tumors of the genital region, were shown to contain human papillomavirus 6 (HPV 6) or HPV 11 genomes.
Boshart, Michael, Hausen, Harald zur
core   +1 more source