Results 11 to 20 of about 23,918,534 (167)

Purification of Long Non-coding RNAs on Replication Forks Using iROND (Isolate RNAs on Nascent DNA)

Bio-Protocol, 2023
Fork stability is key to genome DNA duplication and genetic integrity. Long non-coding RNAs (LncRNAs) may play vital roles in fork stabilization and chromatin remodeling.
Weidao Zhang, Min Tang, Lin Wang, Ping Zheng, Bo Zhao   +4 more
doaj   +1 more source

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing

Nature Biotechnology, 2014
Genome sequencing studies have shown that human malignancies often bear mutations in four or more driver genes, but it is difficult to recapitulate this degree of genetic complexity in mouse models using conventional breeding. Here we use the CRISPR-Cas9
D. Heckl, Monika S. Kowalczyk, David Yudovich, R. Belizaire, Rishi V. Puram, M. McConkey, Anne L. Thielke, J. Aster, A. Regev, B. Ebert   +9 more
semanticscholar   +1 more source

Loss of Life Transformer Prediction Based on Stacking Ensemble Improved by Genetic Algorithm By IJISRT

International Journal of Innovative Science and Research Technology
Prediction for loss of life transfomer is very important to ensure the reliability and efficiency of the power system. In this paper, an innovative model is proposed to improve the accuracy of lost of life transfomer prediction using stacking ensembles ...
Rosena Shintabella, Catur Edi Widodo, Adi Wibowo   +2 more
semanticscholar   +1 more source

The mutational landscapes of genetic and chemical models of Kras-driven lung cancer

Nature, 2014
Next-generation sequencing of human tumours has refined our understanding of the mutational processes operative in cancer initiation and progression, yet major questions remain regarding the factors that induce driver mutations and the processes that ...
Peter M. K. Westcott, Kyle Halliwill, M. To, Mamunur Rashid, A. Rust, Thomas M. Keane, R. Delrosario, Kuang-Yu Jen, K. Gurley, C. Kemp, E. Fredlund, D. Quigley, D. Adams, A. Balmain   +13 more
semanticscholar   +1 more source

Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility

Disease Models & Mechanisms, 2020
Induced pluripotent stem cell (iPSC) technologies have provided in vitro models of inaccessible human cell types, yielding new insights into disease mechanisms especially for neurological disorders.
Viola Volpato, C. Webber
semanticscholar   +1 more source

Fused in sarcoma (FUS) inhibits milk production efficiency in mammals

Nature Communications
Efficient milk production in mammals confers evolutionary advantages by facilitating the transmission of energy from mother to offspring. However, the regulatory mechanism responsible for the gradual establishment of milk production efficiency in mammals,
Haili Shao, Jipeng Huang, Hui Wang, Guolei Wang, Xu Yang, Mei Cheng, Changjie Sun, Li Zou, Qin Yang, Dandan Zhang, Zhen Liu, Xuelong Jiang, Lei Shi, Peng Shi, Baowei Han, Baowei Jiao   +15 more
doaj   +1 more source

Transferring Face Recognition Techniques to Entomology: An ArcFace and ResNet Approach for Improving Dragonfly Classification

Applied Sciences
Dragonfly classification is crucial for biodiversity conservation. Traditional taxonomic approaches require extensive training and experience, limiting their efficiency. Computer vision offers promising solutions for dragonfly taxonomy. In this study, we
Zhong Li, Shaoyan Pu, Jingsheng Lu, Ruibin Song, Haomiao Zhang, Xuemei Lu, Yanan Wang   +6 more
doaj   +1 more source

Historical Perspective: Models of Parkinson’s Disease

International Journal of Molecular Sciences, 2020
Parkinson’s disease (PD) is the most common movement disorder with motor and nonmotor signs. The current therapeutic regimen for PD is mainly symptomatic as the etio-pathophysiology has not been fully elucidated.
Shyh Jenn Chia, E. Tan, Y. Chao
semanticscholar   +1 more source

Regional and aging-specific cellular architecture of non-human primate brains

Genome Medicine
Background Deciphering the functionality and dynamics of brain networks across different regions and age groups in non-human primates (NHPs) is crucial for understanding the evolution of human cognition as well as the processes underlying brain ...
Yun-Mei Wang, Wen-Chao Wang, Yongzhang Pan, Lin Zeng, Jing Wu, Zheng-Bo Wang, Xiao-Lin Zhuang, Ming-Li Li, David N. Cooper, Sheng Wang, Yong Shao, Li-Min Wang, Ying-Yin Fan, Yonghan He, Xin-Tian Hu, Dong-Dong Wu   +15 more
doaj   +1 more source

Generating samples under a Wright-Fisher neutral model of genetic variation

Bioinform., 2002
A Monte Carlo computer program is available to generate samples drawn from a population evolving according to a Wright-Fisher neutral model. The program assumes an infinite-sites model of mutation, and allows recombination, gene conversion, symmetric ...
R. Hudson
semanticscholar   +1 more source