Results 11 to 20 of about 26,076,796 (269)
Combining polynomial chaos expansions and genetic algorithm for the coupling of electrophysiological models [PDF]
, 2019 The number of computational models in cardiac research has grown over the last decades. Every year new models with di erent assumptions appear in the literature dealing with di erences in interspecies cardiac properties.
A Mahajan +17 more
core +2 more sources
Alternate Service Delivery Models in Cancer Genetic Counseling: A Mini-Review
Frontiers in Oncology, 2016 Demand for cancer genetic counseling has grown rapidly in recent years as germline genomic information has become increasingly incorporated into cancer care, and the field has entered the public consciousness through high-profile celebrity publications ...
A. Buchanan, A. Rahm, Janet L. Williams
semanticscholar +1 more source
Genetic draft, selective interference, and population genetics of rapid adaptation [PDF]
, 2013 To learn about the past from a sample of genomic sequences, one needs to understand how evolutionary processes shape genetic diversity. Most population genetic inference is based on frameworks assuming adaptive evolution is rare.
Neher, Richard A.
core +1 more source
The Neolithic transition in Europe: archaeological models and genetic evidence [PDF]
, 2003 The major pattern in the European gene pool is a southeast-northwest frequency gradient of classic genetic markers such as blood groups, which population geneticists initially attributed to the demographic impact of Neolithic farmers dispersing from the ...
Richards, Martin B.
core +4 more sources
Genetic compensation triggered by mutant mRNA degradation
Nature, 2019 Genetic robustness, or the ability of an organism to maintain fitness in the presence of harmful mutations, can be achieved via protein feedback loops. Previous work has suggested that organisms may also respond to mutations by transcriptional adaptation,
Mohamed A. El-Brolosy +13 more
semanticscholar +1 more source
Scientific Reports, 2022 Group sizes in an animal study are calculated from estimates on variation, effect, power and significance level. Much of the variation in glucose related parameters of the diet-induced obese (DIO) mouse model is due to inter-individual variation in gut ...
Valeriia Bondarenko +9 more
doaj +1 more source
Application of a single-objective, hybrid genetic algorithm approach to pharmacokinetic model building. [PDF]
, 2012 A limitation in traditional stepwise population pharmacokinetic model building is the difficulty in handling interactions between model components. To address this issue, a method was previously introduced which couples NONMEM parameter estimation and ...
Belani, Chandra P +12 more
core +2 more sources
Nature Biotechnology, 2014 Genome sequencing studies have shown that human malignancies often bear mutations in four or more driver genes, but it is difficult to recapitulate this degree of genetic complexity in mouse models using conventional breeding. Here we use the CRISPR-Cas9
D. Heckl +9 more
semanticscholar +1 more source
Historical Perspective: Models of Parkinson’s Disease
International Journal of Molecular Sciences, 2020 Parkinson’s disease (PD) is the most common movement disorder with motor and nonmotor signs. The current therapeutic regimen for PD is mainly symptomatic as the etio-pathophysiology has not been fully elucidated.
Shyh Jenn Chia, E. Tan, Y. Chao
semanticscholar +1 more source
International Journal of Innovative Science and Research TechnologyPrediction for loss of life transfomer is very important to ensure the reliability and efficiency of the power system. In this paper, an innovative model is proposed to improve the accuracy of lost of life transfomer prediction using stacking ensembles ...
Rosena Shintabella +2 more
semanticscholar +1 more source