Results 21 to 30 of about 25,628,644 (319)
Genetic Models of Migraine [PDF]
Archives of Neurology, 2007 Migraine is a common, disabling, complex brain disorder, presenting in attacks that may have up to 3 phases: a prodromal phase, the aura phase, and the headache phase. The pathogenesis of the aura and headache phases is reasonably well understood, but the mechanism by which migraine attacks are triggered is unknown.
Rune R. Frants +5 more
openaire +3 more sources
SLiM 3: Forward Genetic Simulations Beyond the Wright–Fisher Model
bioRxiv, 2018 With the desire to model population genetic processes under increasingly realistic scenarios, forward genetic simulations have become a critical part of the toolbox of modern evolutionary biology.
Benjamin C. Haller, Philipp W. Messer
semanticscholar +1 more source
Alternate Service Delivery Models in Cancer Genetic Counseling: A Mini-Review
Frontiers in Oncology, 2016 Demand for cancer genetic counseling has grown rapidly in recent years as germline genomic information has become increasingly incorporated into cancer care, and the field has entered the public consciousness through high-profile celebrity publications ...
A. Buchanan, A. Rahm, Janet L. Williams
semanticscholar +1 more source
Genetic compensation triggered by mutant mRNA degradation
Nature, 2019 Genetic robustness, or the ability of an organism to maintain fitness in the presence of harmful mutations, can be achieved via protein feedback loops. Previous work has suggested that organisms may also respond to mutations by transcriptional adaptation,
Mohamed A. El-Brolosy +13 more
semanticscholar +1 more source
Advances in pig models of human diseases
Animal Models and Experimental Medicine, 2022 Animal models of human diseases play a critical role in medical research. Pigs are anatomically and physiologically more like humans than are small rodents such as mice, making pigs an attractive option for modeling human diseases.
Naipeng Hou, Xuguang Du, Sen Wu
semanticscholar +1 more source
Genetic mouse models of migraine [PDF]
The Journal of Headache and Pain, 2019 Mouse models of rare monogenic forms of migraine provide a unique experimental system to study the cellular and circuit mechanisms of the primary brain dysfunctions causing a migraine disorder. Here, we discuss the migraine-relevant phenotypes and the migraine-relevant functional alterations in the brain of five genetic mouse models of migraine, four ...
Pietrobon D., Brennan K. C.
openaire +4 more sources
Genetic model misspecification in genetic association studies [PDF]
BMC Research Notes, 2017 The underlying model of the genetic determinant of a trait is generally not known with certainty a priori. Hence, in genetic association studies, a dominant model might be erroneously modelled as additive, an error investigated previously. We explored this question, for candidate gene studies, by evaluating the sample size required to compensate for ...
Amadou Gaye, Sharon K. Davis
openaire +4 more sources
Genetic models of focal epilepsies [PDF]
Journal of Neuroscience Methods, 2016 Focal epilepsies were for a long time thought to be acquired disorders secondary to cerebral lesions. However, the important role of genetic factors in focal epilepsies is now well established. Several focal epilepsy syndromes are now proven to be monogenic disorders.
Boillot, Morgane, Baulac, Stéphanie
openaire +4 more sources
Nature Biotechnology, 2014 Genome sequencing studies have shown that human malignancies often bear mutations in four or more driver genes, but it is difficult to recapitulate this degree of genetic complexity in mouse models using conventional breeding. Here we use the CRISPR-Cas9
D. Heckl +9 more
semanticscholar +1 more source
Historical Perspective: Models of Parkinson’s Disease
International Journal of Molecular Sciences, 2020 Parkinson’s disease (PD) is the most common movement disorder with motor and nonmotor signs. The current therapeutic regimen for PD is mainly symptomatic as the etio-pathophysiology has not been fully elucidated.
Shyh Jenn Chia, E. Tan, Y. Chao
semanticscholar +1 more source