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Construction of neural system disease models from the perspective of cellular biomechanics and their application in teaching practice [PDF]
Frontiers in Bioengineering and BiotechnologyBackgroundNeurological diseases such as Alzheimer’s, Parkinson’s, and multiple sclerosis present significant challenges to healthcare systems due to their complex pathophysiological mechanisms. Recent advancements in cellular biomechanics have opened new
Hong Xue +4 more
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Alzheimer’s Research & Therapy, 2022 Background Gangliosides are highly enriched in the brain and are critical for its normal development and function. However, in some rare neurometabolic diseases, a deficiency in lysosomal ganglioside hydrolysis is pathogenic and leads to early-onset ...
James C. Dodge +7 more
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Neurorobotic Models of Neurological Disorders: A Mini Review
Frontiers in Neurorobotics, 2021 Modeling is widely used in biomedical research to gain insights into pathophysiology and treatment of neurological disorders but existing models, such as animal models and computational models, are limited in generalizability to humans and are restricted
Savva Pronin +5 more
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Neural Regeneration Research, 2022 Cell-based models are a promising tool in deciphering the molecular mechanisms underlying the pathogenesis of neurological disorders as well as aiding in the discovery and development of future drug therapies.
Jake Langlie +7 more
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Animal Models of Neurological Disorders: Where Are We Now?
Biomedicines, 2023 The Special Issue “Animal Models of Neurological Disorders: Where Are We Now [...]
Sandesh Panthi, Marc Ekker
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Cerebellar dysfunction in rodent models with dystonia, tremor, and ataxia
Dystonia, 2023 Dystonia is a movement disorder characterized by involuntary co- or over-contractions of the muscles, which results in abnormal postures and movements. These symptoms arise from the pathophysiology of a brain-wide dystonia network.
Meike E. van der Heijden +6 more
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Medicina, 2019 Background and Objectives: The knowledge that the cholinergic neurons from pedunculopontine nucleus (PPN) are vulnerable to the degeneration in early stages of the Parkinson disease progression has opened new perspectives to the development of ...
Lisette Blanco-Lezcano +9 more
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CHANGING PERSPECTIVE ON PERCEPTION PHYSIOLOGY: CAN YOU REALLY SEE WHAT IS HAPPENING?
Euromediterranean Biomedical Journal, 2018 Perception is a complex, neural mechanism that requires organization and interpretation of input meaning and it has been a key topic in medicine, neuroscience and philosophy for centuries.
Giuseppe Giglia
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Influence of data sampling methods on the representation of neural spiking activity in vivo
iScience, 2022 Summary: In vivo single-unit recordings distinguish the basal spiking properties of neurons in different experimental settings and disease states. Here, we examined over 300 spike trains recorded from Purkinje cells and cerebellar nuclei neurons to test ...
Meike E. van der Heijden +2 more
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Isoprostanoids in Clinical and Experimental Neurological Disease Models
Antioxidants, 2018 Isoprostanoids are a large family of compounds derived from non-enzymatic oxidation of polyunsaturated fatty acids (PUFAs). Unlike other oxidative stress biomarkers, they provide unique information on the precursor of the targeted PUFA.
Cinzia Signorini +9 more
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