Results 1 to 10 of about 777,778 (283)

Preclinical and experimental evidence of salvianolic acid B in the treatment of neurological diseases [PDF]

Frontiers in Pharmacology
BackgroundNeurological diseases such as stroke and Alzheimer’s disease pose increasing challenges to global public health. Salvianolic Acid B (SalB), a major active component of Salvia miltiorrhiza, has garnered attention due to its anti-inflammatory ...
Shijun Bi, Shibing Liu, Kunyuan Zhu, Dandan Gao, Ligang Chen, Chunyong Yu, Guobiao Liang   +6 more
doaj   +2 more sources

Isoprostanoids in Clinical and Experimental Neurological Disease Models [PDF]

Antioxidants, 2018
Isoprostanoids are a large family of compounds derived from non-enzymatic oxidation of polyunsaturated fatty acids (PUFAs). Unlike other oxidative stress biomarkers, they provide unique information on the precursor of the targeted PUFA.
Cinzia Signorini, Claudio De Felice, Jean-Marie Galano, Camille Oger, Silvia Leoncini, Alessio Cortelazzo, Lucia Ciccoli, Thierry Durand, Joussef Hayek, Jetty Chung-Yung Lee   +9 more
doaj   +6 more sources

Porcine Models of Neurotrauma and Neurological Disorders

Biomedicines
The translation of therapeutics from lab to clinic has a dismal record in the fields of neurotrauma and neurological disorders [...]
John C. O’Donnell, Dmitriy Petrov
doaj   +3 more sources

Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer’s disease

Alzheimer’s Research & Therapy, 2022
Background Gangliosides are highly enriched in the brain and are critical for its normal development and function. However, in some rare neurometabolic diseases, a deficiency in lysosomal ganglioside hydrolysis is pathogenic and leads to early-onset ...
James C. Dodge, Thomas J. Tamsett, Christopher M. Treleaven, Tatyana V. Taksir, Peter Piepenhagen, S. Pablo Sardi, Seng H. Cheng, Lamya S. Shihabuddin   +7 more
doaj   +1 more source

Neurorobotic Models of Neurological Disorders: A Mini Review

Frontiers in Neurorobotics, 2021
Modeling is widely used in biomedical research to gain insights into pathophysiology and treatment of neurological disorders but existing models, such as animal models and computational models, are limited in generalizability to humans and are restricted
Savva Pronin, Savva Pronin, Liam Wellacott, Jhielson Pimentel, Renan C. Moioli, Patricia A. Vargas   +5 more
doaj   +1 more source

Animal Models of Neurological Disorders [PDF]

Neurotherapeutics, 2005
The discovery of new therapies for neurological disorders is predicated on the use of animal models both to identify new therapeutic targets and to perform preclinical trials of drugs before using them in patients. In both cases, the challenge is to develop models that recapitulate the disorder.
Marie-Francoise, Chesselet, S Thomas, Carmichael   +1 more
openaire   +5 more sources

Unraveling pathological mechanisms in neurological disorders: the impact of cell-based and organoid models

Neural Regeneration Research, 2022
Cell-based models are a promising tool in deciphering the molecular mechanisms underlying the pathogenesis of neurological disorders as well as aiding in the discovery and development of future drug therapies.
Jake Langlie, Rahul Mittal, Ariel Finberg, Nathalie B Bencie, Jeenu Mittal, Hossein Omidian, Yadollah Omidi, Adrien A Eshraghi   +7 more
doaj   +1 more source

Animal Models of Neurological Disorders: Where Are We Now?

Biomedicines, 2023
The Special Issue “Animal Models of Neurological Disorders: Where Are We Now [...]
Sandesh Panthi, Marc Ekker
doaj   +1 more source

Cerebellar dysfunction in rodent models with dystonia, tremor, and ataxia

Dystonia, 2023
Dystonia is a movement disorder characterized by involuntary co- or over-contractions of the muscles, which results in abnormal postures and movements. These symptoms arise from the pathophysiology of a brain-wide dystonia network.
Meike E. van der Heijden, Meike E. van der Heijden, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe   +6 more
doaj   +1 more source

Influence of data sampling methods on the representation of neural spiking activity in vivo

iScience, 2022
Summary: In vivo single-unit recordings distinguish the basal spiking properties of neurons in different experimental settings and disease states. Here, we examined over 300 spike trains recorded from Purkinje cells and cerebellar nuclei neurons to test ...
Meike E. van der Heijden, Amanda M. Brown, Roy V. Sillitoe   +2 more
doaj   +1 more source