Results 1 to 10 of about 830,611 (284)
Construction of neural system disease models from the perspective of cellular biomechanics and their application in teaching practice [PDF]
Frontiers in Bioengineering and BiotechnologyBackgroundNeurological diseases such as Alzheimer’s, Parkinson’s, and multiple sclerosis present significant challenges to healthcare systems due to their complex pathophysiological mechanisms. Recent advancements in cellular biomechanics have opened new
Hong Xue +4 more
doaj +2 more sources
Models of Cognition: Neurological possibility does not indicate neurological plausibility [PDF]
, 2005 Many activities in Cognitive Science involve complex computer models and simulations of both theoretical and real entities. Artificial Intelligence and the study of artificial neural nets in particular, are seen as major contributors in the quest for ...
Krebs, Peter R.
core +2 more sources
Animal Models of Neurological Disorders [PDF]
Neurotherapeutics, 2012 The discovery of new therapies for neurological disorders is predicated on the use of animal models both to identify new therapeutic targets and to perform preclinical trials of drugs before using them in patients. In both cases, the challenge is to develop models that recapitulate the disorder.
Marie-Francoise, Chesselet +1 more
+5 more sources
Alzheimer’s Research & Therapy, 2022 Background Gangliosides are highly enriched in the brain and are critical for its normal development and function. However, in some rare neurometabolic diseases, a deficiency in lysosomal ganglioside hydrolysis is pathogenic and leads to early-onset ...
James C. Dodge +7 more
doaj +1 more source
Neurorobotic Models of Neurological Disorders: A Mini Review
Frontiers in Neurorobotics, 2021 Modeling is widely used in biomedical research to gain insights into pathophysiology and treatment of neurological disorders but existing models, such as animal models and computational models, are limited in generalizability to humans and are restricted
Savva Pronin +5 more
doaj +1 more source
Neural Regeneration Research, 2022 Cell-based models are a promising tool in deciphering the molecular mechanisms underlying the pathogenesis of neurological disorders as well as aiding in the discovery and development of future drug therapies.
Jake Langlie +7 more
doaj +1 more source
Animal Models of Neurological Disorders: Where Are We Now?
Biomedicines, 2023 The Special Issue “Animal Models of Neurological Disorders: Where Are We Now [...]
Sandesh Panthi, Marc Ekker
doaj +1 more source
Cerebellar dysfunction in rodent models with dystonia, tremor, and ataxia
Dystonia, 2023 Dystonia is a movement disorder characterized by involuntary co- or over-contractions of the muscles, which results in abnormal postures and movements. These symptoms arise from the pathophysiology of a brain-wide dystonia network.
Meike E. van der Heijden +6 more
doaj +1 more source
Computational Neurology: Computational Modeling Approaches in Dementia [PDF]
, 2021 Dementia is a collection of symptoms associated with impaired cognition and impedes everyday normal functioning. Dementia, with Alzheimer's disease constituting its most common type, is highly complex in terms of etiology and pathophysiology. A more quantitative or computational attitude towards dementia research, or more generally in neurology, is ...
Wong-Lin, KongFatt +16 more
openaire +3 more sources
Medicina, 2019 Background and Objectives: The knowledge that the cholinergic neurons from pedunculopontine nucleus (PPN) are vulnerable to the degeneration in early stages of the Parkinson disease progression has opened new perspectives to the development of ...
Lisette Blanco-Lezcano +9 more
doaj +1 more source