Results 121 to 130 of about 518,429 (303)

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Transgenic models for cytokine-induced neurological disease

, 2010
Considerable evidence supports the idea that cytokines are important mediators of pathophysiologic processes within the central nervous system (CNS). Numerous studies have documented the increased production of various cytokines in the human CNS in a ...
Axel Pagenstecher, Hofer, Markus J., Iain L. Campbell, Pagenstecher, Axel, Campbell, Iain L., Markus J. Hofer   +5 more
core   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

CASE REPORT: STROKE PREDICTION MODELS AFTER TRANSIENT ISCHEMIC ATTACK WITH ATRIAL FIBRILLATION

, 2019
Background : Atrial fibrillation (AF) is an independent risk factor for stroke. The role of AF in transient ischemic attack (TIA) is less common. Thus, this situation cannot be underestimated because both TIA and AF are increasing the risk of a patient ...
Rubianto, Mason, Yusuf, Samudra Andi, Giovani, Stefano   +2 more
core   +1 more source

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

Smartphone postural sway and pronator drift tests as measures of neurological disability

BMC Neurology
The COVID-19 pandemic and increased demands for neurologists have inspired the creation of remote, digitalized tests of neurological functions. This study investigates two tests from the Neurological Functional Tests Suite (NeuFun-TS) smartphone ...
Michael Calcagni, Peter Kosa, Bibi Bielekova   +2 more
doaj   +1 more source

Recreating the human brain: Are assembloids merely descriptive models?

Frontiers in Cellular Neuroscience
Assembloids, engineered fusions of region-specific brain 3D constructs, have emerged as powerful platforms to study neurodevelopment and neurological diseases.
Yara Izhiman, Charitha Anamala, Eric A. Nauman, Eric A. Nauman, Volha Liaudanskaya, Volha Liaudanskaya   +5 more
doaj   +1 more source

Targeting neurological disease with RNAi

, 2007
The neuroscientific community rapidly adopted RNA interference techniques as an experimental tool for the dissection of gene function in vitro and in animal models of neurological disease in vivo.
Lingor, P., Bähr, M.
core   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Large language models to infer depression in patients with neurological conditions

BMJ Neurology Open
Objective To develop and validate a large language model (LLM) prompt capable of ascertaining a patient’s depression from their multiple sclerosis (MS) neurologist’s note and to explore its potential for earlier detection of depression in MS care ...
Jeffrey Marc Gelfand, Riley Bove, Kyra Henderson, Jaeleene Wijangco, Chu-Yueh Guo, Maya Julian-Kwong, Shane Poole, Nikki Sisodia   +7 more
doaj   +1 more source